Recent Awards Dr. David Clouthier; INDEPENDENT SCIENTIST AWARD (K02) - $467,635 - 5 years; Provides salary support for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. This award is intended to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. Dr. M. Michele Pisano, mentor for John Philipose, D.M.D; MENTORED CLINICAL SCIENTIST DEVELOPMENT AWARD (K08) - $410,395 - 5 years; Supports the development of outstanding clinician research scientists. This mechanism provides specialized study for individuals with a health professional doctoral degree committed to a career in laboratory or field-based research. Candidates must have the potential to develop into independent investigators. Dr. Philipose, under the direction of Dr. Michele Pisano and Dr. Anibal Silvera will pursue a 6 year program culminating in the award of a Ph.D. degree and completion of a residency in Orthodontics. Dr. M. Michele Pisano and Dr. Norbert Burzynski; CANCER EDUCATION GRANT (R25) - $516,145 - 5 years; The purpose of this program is to disseminate, to health professional students, an appreciation for issues in cancer biology as they relate to diagnosis, prevention and treatment of the disease, from a clinical and research perspective. A new Health Science Center-wide training venture has been initiated, which benefits from the participation of eighteen core faculty, all of whom are funded extensively through federal/foundation sources and have a demonstrated commitment to biomedical research and education. This multidisciplinary group represents a forging of research and training partnerships spanning seven University departments and incorporating the University of Louisville Schools of Dentistry and Medicine, J. Graham Brown Cancer Center, Birth Defects Center, Center for Genetics and Molecular Medicine, and Kosair Children's Hospital Research Institute. David Hein: Title: Pharmacogenetics of drug and carcinogen metabolism Funding Agency: NIH/NCI (R01-CA34627) Project Period: July 1, 2003 to June 30, 2008 Project Award $1,724,900 (total) This project will investigate the role of genetic predisposition to breast cancer from chemicals present in cigarette smoke and in the diet. M. Michele Pisano: Title: Molecular Analyses of Cranial Embryonic Stem Cells Role in Project: Principal Investigator Funding Agency: KSEF Project Period: July 1, 2004 to June 30, 2006 Project Award: $101,200 Jixiang Ding:: Title: Regulation of Nodal Signaling in Holoprosencephaly Role in Project: Principal Investigator Funding Agency: NIH Project Period: July 1, 2004 to June 30, 2009 Project Award: $1,125,000 (DIRECTS) David Hein: Title: Characterization of NAT1 overexpression in breast tumors Role in Project: Principal Investigator Funding Agency: NIH/NCI (Supplement to R01-CA34627) through the APRC program Project Period: July 1, 2004 to June 30, 2006 Project Award: $113,750 (total) David Hein: Title: Mechanistic studies on the NAT2 genetic polymorphism: A potential factor that modifies individual breast cancer risk Role in Project: Principal Investigator (Mentor for Yu [Janet] Zang) Funding Agency: Susan G. Komen Breast Cancer Foundation (DISS0403147) Project Period: May 1, 2004 to April 30, 2006 Project Award: $30,000 (total) David Hein: Title: Human hepatocyte characterization Role in Project: Principal Investigator Funding Agency: Tissue Transformation Technologies Project Period: March 1, 2004 to December 31, 2004 Project Award: $1,386 (total)