The Administrative Core provides overall governance and ensures that the ULARC projects and cores work together in a cohesive and coordinated manner. The Administrative Core provides a formalized governance structure and provides formalized processes for replacing key personnel. In addition, the Administrative Core provides training/mentoring support, “chain of custody” tissue handling support, and biostatistical support.
The overall Education goal of the ULARC is to provide mentoring to junior faculty, and training to graduate and medical students, post-doctoral fellows, residents and medical fellows, as well as to “prime the pump” by offering training opportunities to undergraduate and high school students. Important to developing a highly productive and sustained alcohol research enterprise at UofL is the development of senior mentors in alcohol research to advance the careers of our mentees/junior faculty and to advance alcohol research at UofL. All junior faculty are encouraged to become mentors.
One goal of the ULARC is to develop a formalized training program—didactic and mentored research—in alcohol research. There are a number of seminar series in which the ULARC participates and we also offer opportunities for mentored research to fellows in training and/or junior faculty.
Jesse Roman, MD,: Education Leader: Dr. Roman is Professor of Medicine, and Pharmacology & Toxicology, Chair of the Department of Medicine, and Distinguished University Scholar at the UofL. Dr. Roman’s research has been continuously funded by federal and non-federal organizations including the National Institutes of Health, Department of Veterans Affairs, private foundations, and industry support. Dr. Roman’s involvement in education, mentorship, faculty development, and diversity has been quite extensive. Dr. Roman was the PI and training director on a T32 NRSA at Emory (HL076118-06) and served as a mentor on another T32 (T32 AA13528-01). He has also served as the senior mentor for an individual NRSA grant and three NIH K awards. Additionally, Dr. Roman served as a mentor of an NIH K12-Award (RR017643-03), as chair of the Education Committee of the NIH IPFnet, and on the External Advisory Committee of the T35 Pulmonary Program for Minority Students of Indiana University. Dr. Roman will have overall responsibility for this aim and will serve as a role model for physician scientists.
Matt Cave, MD: Dr. Cave is Assoc. Prof. (Gastroenterology, Hepatology & Nutrition) in the Department of Medicine. Dr. Cave has done groundbreaking research on environmental liver disease, and his dual interests in alcohol-induced liver disease and environmental liver disease (R01-funded) gives him a unique perspective on these important causes of liver injury and their interrelationships. Dr. Cave is a former NIAAA K23 awardee studying the effects of zinc deficiency/supplementation in ALD. Dr. Cave will participate at a “grassroots” level in involving students at all levels in clinical/translational research on alcohol-induced organ injury. Dr. Cave is a sought-after mentor for graduate students, and his students have been very successful.
Gavin E. Arteel, PhD: Dr. Arteel is Professor of Pharmacology & Toxicology, Distinguished University Scholar, and Associate Chair for Research in the Department of Pharmacology & Toxicology. He received his PhD from the University of North Carolina, Chapel Hill, where he was an NRSA Predoctoral fellow. He did one post-doctoral fellowship at the Institut für Physiologische Chemie I, Heinrich Heine Universität in Düsseldorf, Germany and an NRSA post-doctoral fellowship at the Bowles Center for Alcohol Studies at the University of North Carolina, Chapel Hill. He serves on the XNDA study section and has been an ad hoc reviewer for NIAAA, NIDDK and NIEHS. He is a former NIAAA K01 awardee. He is an active mentor/advisor for graduate students and post-doctoral fellows having served as primary advisor for 29 graduate students and post-docs, plus serving on another 12 graduate student committees. He is widely published in prestigious journals and is a sought-after invited lecturer at national and international meetings. Dr. Arteel’s research focuses on the interaction between hepatotoxins (e.g., arsenic) and lifestyle choices (e.g., obesity and alcohol) in the initiation and progression of chronic liver diseases. He will provide education leadership for the formalized training programs and basic science mentoring.
A major goal for the ULARC is the development of a curriculum to educate a new generation of investigators performing translational alcohol research. We anticipate having 1-2 scholars at any given time. Scholar candidates will apply by March of a given year, will be interviewed and chosen by July and will matriculate by August. All trainees/students will also be required to be fully knowledgeable about the responsible conduct of human and animal research. Alcohol Scholars include:
Ammar Hassan, MD.
Project: Mechanisms of ALD
Nutrient: Protein malnutrition
Nihar Shah, MD
Project: CK-18 and Alcoholic Hepatitis
“Chain of Custody”
We support a part-time technician to obtain animal and human specimens from investigators for storage. This person is a skilled technician, with several years’ experience. This person will store and archive all animal specimens and keep a record of the experimental feeding/alcohol exposure for future reference. Thus, future users can correlate experimental protocols with tissue findings. For human samples, the technician will obtain stool/blood/urine/tissue from the PIs of the human protocols and will store and archive the samples, again detailing the patient’s condition (e.g., cirrhosis, AH, etc.) and treatment protocols. This service will provide ‘chain of custody’ for all samples and protocols and will facilitate future use and research on those samples.
Data management and statistical support are integral functions of the Administrative Core. These functions are provided on a fee-for-service basis.