Craig J. McClain, M.D.

Craig J. McClain, M.D.

Craig J. McClain, M.D.

Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Translational Research
  • Distinguished University Scholar
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991- Academic Office
502-813-6500 - Patient Appointments


Clinical Expertise
Alcoholic Liver Disease; Non-alcholic steatohepatitis; Nutrition

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Gastroenterology
  • Certification Board for Nutrition Specialists
  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee
  • Residency: University of Pittsburgh Hospitals
  • Fellowship: University of Minnesota Hospitals

 

 

Recent Publications

      • Wang Y, Liu Y, Sidhu A, Ma Z, McClain C, Feng W.  Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.  Am J Physiol Gastrointest Liver Physiol, 2012 Apr 26. [Epub ahead of print]   PMID:  22538402   PMCID: PMC3404581.
      • Kirpich IA, McClain CJ.  Probiotics in the treatment of the liver diseases.  J Am Coll Nutr, 2012; 31(1):14-23.  PMID: 22661622.
      • Bull-Otterson L, Feng W, Kirpich I, Wang Y, Qin X, Liu Y, Gobejishvili L, Joshi-Barve S, Ayvaz T, Petrosino J, McClain C, Barve S.  Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosis GG treatment.  PLOS One, 2013, 8(1):e53028. doi:10.1371/journal.pone.0053028. PMID: 23326376; PMCID: PMC3541399.
      • Smart L, Gobejishvili L, Crittenden N, Barve S, McClain CJ. Alcoholic Hepatitis: Steroids vs.   Pentoxifylline  Current Hepatitis Reports, published online 22 Jan 2013 doi:10.1007/s11901-012-0158-y. 2013 Mar 1;12(1):59-65 . PMID  23750115;  PMCID: PMC3671597.
      • Wei X, Shi X, Zhong W, Zhao Y, Tang Y, Sun W, Yin X, Bogdanov B, Kim S, McClain CJ, Zhou Z, Zhang X. Chronic Alcohol Exposure Disturbs Lipid Homeostasis at the Adipose-Liver Axis in mice: Analysis of Triacylglycerols Using High-Resolution Mass Spectrometry in Combination with in vivo Metabolite Deuterium Labeling.  PLOS ONE, 2013, 8(2):e55382 doi: 10.1371/journal.pone.0055382 Epub 2013 Feb 6.  PMID: 23405143; PMCID: PMC3566154.
      • Kirpich I, Feng W, Wang Y, Liu Y, Beier J, Arteel G, Falkner KC, Barve S, McClain C.  Ethanol and Dietary Unsaturated Fat (Corn Oil/Linoleic Acid Enriched) Cause Intestinal Inflammation and Impaired Intestinal Barrier Defense in Mice Chronically Fed Alcohol. Alcohol 2013 May;47(3):257-64. Doi:10.1016/j.alcohol.2013.01.005. E-pub 2013 Feb 26.  PMID: 23665587; PMCID:PMC3617059.
      • Song M, Schuschke DA, Zhou Z, Chen T, Shi X, Zhang J, Zhang X, Pierce WM Jr, Johnson WT, McClain CJ.  Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats.  Obesity (Silver Spring) 2013 Mar 20 doi:10.1002/oby.2038 [E-pub ahead of print]  PMID: 23512597; PMCID: PMC3695073.
      • Wang Y, Liu Y, Kirpich I, Ma Z, Wang C, Zhang M, Suttles J, McClain C, Feng W.  Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury.  J. Nutr Biochem. 2013 Sept;24(9):1609-15  doi:pii: S0955-2863(13)00039-0. 10.1016/j.jnutbio.3013.02.001 E-pub 2013 Apr 22  PMID: 23618528; PMCID: PMC3804118.
      • Gobejishvili L, Barve S, Breitkopf-Heinlein K, Li Y, Zhang J, Avila D, Dooley S, McClain, CJ.  Rolipram Attenuates Bile Duct Ligation-Induced Liver Injury in Rats; A Potential Pathogenic Role of PDE4.  J Pharmacol Exp Ther 2013 Oct;347(1):80-90. Epub 2013 Jul 25. PMID: 23887098; PMCID:PMC3781411.
      • Zhong W, Zhao Y, Sun X, Song Z, McClain C, Zhou Z.  Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: Involvement of intrahepatic and extrahepatic factors. PLOS One, 2013 October 8(10):e76522 doi:10.1371/journal.pone.0076522. PMID: 24155903; PMCID:PMC3796541.