Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

Craig J. McClain, M.D.

Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Health Affairs/Research
  • Associate Vice President for Translational Research
  • Director, Clinical Trials Unit / Liver Research Program
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Alcoholic Liver Disease; Non-Alcoholic Steatohepatitis; Nutrition


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Gastroenterology
  • Certification Board for Nutrition Specialists
  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee
  • Residency: University of Pittsburgh Hospitals
  • Fellowship: University of Minnesota Hospitals

Featured Publications

  • Kirpich IA, McClain CJ. Introduction to the Virtual Issue "Translational Studies in AUD: Liver Disease". Alcohol Clin Exp Res. 2019 Apr;43(4):593-596. doi: 10.1111/acer.13967. Epub 2019 Feb 27. PubMed PMID: 30694554; PubMed Central PMCID: PMC6443476.
  • Saha B, Tornai D, Kodys K, Adejumo A, Lowe P, McClain C, Mitchell M, McCullough A, Srinivasan D, Kroll-Desrosiers A, Barton B, Radaeva S, Szabo G. Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis. Hepatology. 2019 Mar 19. doi: 10.1002/hep.30617. [Epub ahead of print] PubMed PMID: 30891779.
  • He L, Wei X, Ma X, Yin X, Song M, Donninger H, Yaddanapudi K, McClain CJ, Zhang X. Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples. J Am Soc Mass Spectrom. 2019 Mar 7. doi: 10.1007/s13361-019-02140-7. [Epub ahead of print] PubMed PMID: 30847833.
  • Vatsalya V, Cave MC, Kumar R, Srivastava S, Khanal S, Jenson AB, Schwandt ML, Barve SS, Ramchandani VA, McClain CJ. Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury. AIDS Res Hum Retroviruses. 2019 Jan;35(1):92-99. doi: 10.1089/AID.2018.0124. Epub 2018 Dec 11. PubMed PMID: 30280905; PubMed Central PMCID: PMC6343188.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.
  • Zhou Y, Vatsalya V, Gobejishvili L, Lamont RJ, McClain CJ, Feng W. Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis. Hepatol Commun. 2018 Dec 14;3(2):293-304. doi: 10.1002/hep4.1296. eCollection 2019 Feb. PubMed PMID: 30766965; PubMed Central PMCID: PMC6357836.
  • Song M, Vos MB, McClain CJ. Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD. Nutrients. 2018 Nov 21;10(11). pii: E1815. doi: 10.3390/nu10111815. Review. PubMed PMID: 30469339; PubMed Central PMCID: PMC6266129.
  • Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, Hutchins E, Mu J, Deng Z, Luo C, Sundaram K, Sriwastva MK, Zhang L, Hsieh M, Reiman R, Haribabu B, Yan J, Jala VR, Miller DM, Van Keuren-Jensen K, Merchant ML, McClain CJ, Park JW, Egilmez NK, Zhang HG. Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota. Cell Host Microbe. 2018 Nov 14;24(5):637-652.e8. doi: 10.1016/j.chom.2018.10.001. Epub 2018 Oct 25. PubMed PMID: 30449315.
  • Ramsden CE, Hennebelle M, Schuster S, Keyes GS, Johnson CD, Kirpich IA, Dahlen JE, Horowitz MS, Zamora D, Feldstein AE, McClain CJ, Muhlhausler BS, Makrides M, Gibson RA, Taha AY. Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1206-1213. doi: 10.1016/j.bbalip.2018.07.007. Epub 2018 Jul 25. PubMed PMID: 30053599; PubMed Central PMCID: PMC6180905.
  • Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W. Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol. 2018 Oct;69(4):886-895. doi: 10.1016/j.jhep.2018.05.021. Epub 2018 May 25. PubMed PMID: 29803899.