Craig J. McClain, M.D.

Craig J. McClain, M.D.

Craig J. McClain, M.D.

Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Health Affairs/Research
  • Associate Vice President for Translational Research
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Alcoholic Liver Disease; Non-Alcoholic Steatohepatitis; Nutrition

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Gastroenterology
  • Certification Board for Nutrition Specialists
  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee
  • Residency: University of Pittsburgh Hospitals
  • Fellowship: University of Minnesota Hospitals

 

 

Featured Publications

  • Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules. 2018 Mar 26;8(2). pii: E16. doi: 10.3390/biom8020016. PubMed PMID: 29587455.
  • Prodhan MAI, Yin X, Kim S, McClain C, Zhang X. Surface fitting for calculating the second dimension retention index in comprehensive two-dimensional gas chromatography mass spectrometry. J Chromatogr A. 2018 Mar 2;1539:62-70. doi: 10.1016/j.chroma.2018.01.049. Epub 2018 Jan 31. PubMed PMID: 29395161; PubMed Central PMCID: PMC5826898.
  • Ghosh Dastidar S, Warner JB, Warner DR, McClain CJ, Kirpich IA. Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration. Biomolecules. 2018 Jan 13;8(1). pii: E3. doi: 10.3390/biom8010003. Review. PubMed PMID: 29342874; PubMed Central PMCID: PMC5871972.
  • Song M, Li X, Zhang X, Shi H, Vos MB, Wei X, Wang Y, Gao H, Rouchka EC, Yin X, Zhou Z, Prough RA, Cave MC, McClain CJ. Dietary copper-fructose interactions alter gut microbial activity in male rats. Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G119-G130. doi: 10.1152/ajpgi.00378.2016. Epub 2017 Oct 12. PubMed PMID: 29025734; PubMed Central PMCID: PMC5866377.
  • Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability. Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19. PubMed PMID: 28935573; PubMed Central PMCID: PMC5818631.
  • Kirpich I, McClain C. More Alcohol, More Liver Injury: Not Always True. Alcohol Alcohol. 2017 Nov 1;52(6):627-628. doi: 10.1093/alcalc/agx064. PubMed PMID: 29036522.
  • Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA. Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice. Am J Pathol. 2017 Oct;187(10):2232-2245. doi: 10.1016/j.ajpath.2017.06.008. PubMed PMID: 28923202; PubMed Central PMCID: PMC5808136.
  • Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology. 2017 Oct;125:376-385. doi: 10.1016/j.neuropharm.2017.08.011. Epub 2017 Aug 12. PubMed PMID: 28807677; PubMed Central PMCID: PMC5797427.
  • Kong X, Yang Y, Ren L, Shao T, Li F, Zhao C, Liu L, Zhang H, McClain CJ, Feng W. Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling. Sci Rep. 2017 Aug 24;7(1):9292. doi: 10.1038/s41598-017-09045-z. PubMed PMID: 28839246; PubMed Central PMCID: PMC5571015.
  • Wei X, Shi B, Koo I, Yin X, Lorkiewicz P, Suhail H, Rattan R, Giri S, McClain CJ, Zhang X. Analysis of stable isotope assisted metabolomics data acquired by GC-MS. Anal Chim Acta. 2017 Aug 8;980:25-32. doi: 10.1016/j.aca.2017.05.002. Epub 2017 May 13. PubMed PMID: 28622800; PubMed Central PMCID: PMC5541907.