Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

Craig J. McClain, M.D.

Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Health Affairs/Research
  • Associate Vice President for Translational Research
  • Director, Clinical Trials Unit / Liver Research Program
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Alcoholic Liver Disease; Non-Alcoholic Steatohepatitis; Nutrition


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Gastroenterology
  • Certification Board for Nutrition Specialists
  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee
  • Residency: University of Pittsburgh Hospitals
  • Fellowship: University of Minnesota Hospitals

Featured Publications

  • Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK. Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium. Alcohol. 2020 Mar;83:105-114. doi: 10.1016/j.alcohol.2019.05.004. Epub 2019 May 23. Review. PubMed PMID: 31129175; PubMed Central PMCID: PMC7043088.
  • Wang M, Chen WY, Zhang J, Gobejishvili L, Barve SS, McClain CJ, Joshi-Barve S. Elevated fructose and uric acid via aldose reductase contribute to experimental and human alcoholic liver disease. Hepatology. 2020 Feb 22. doi: 10.1002/hep.31197. [Epub ahead of print] PubMed PMID: 32086945.
  • Vatsalya V, Gala KS, Mishra M, Schwandt ML, Umhau J, Cave MC, Parajuli D, Ramchandani VA, McClain CJ. Lower Serum Magnesium Concentrations are associated With Specific Heavy Drinking Markers, Pro-Inflammatory Response and Early-Stage Alcohol-associated Liver Injury§. Alcohol Alcohol. 2020 Feb 12. pii: agaa001. doi: 10.1093/alcalc/agaa001. [Epub ahead of print] PubMed PMID: 32047901.
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock G, Cave MC. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004. Environ Sci Pollut Res Int. 2020 Feb;27(6):6476-6487. doi: 10.1007/s11356-019-07066-x. Epub 2019 Dec 23. PubMed PMID: 31873887; PubMed Central PMCID: PMC7047555.
  • Liu Q, Liu Y, Li F, Gu Z, Liu M, Shao T, Zhang L, Zhou G, Pan C, He L, Cai J, Zhang X, Barve S, McClain CJ, Chen Y, Feng W. Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. J Nutr Biochem. 2020 Jan;75:108256. doi: 10.1016/j.jnutbio.2019.108256. Epub 2019 Oct 24. PubMed PMID: 31760308.
  • Vatsalya V, Cave MC, Kong M, Gobejishvili L, Falkner KC, Craycroft J, Mitchell M, Szabo G, McCullough A, Dasarathy S, Radaeva S, Barton B, McClain CJ. Keratin 18 is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2019 Dec 4. pii: S1542-3565(19)31390-4. doi: 10.1016/j.cgh.2019.11.050. [Epub ahead of print] PubMed PMID: 31811953.
  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench. Hepatology. 2019 Dec;70(6):1958-1971. doi: 10.1002/hep.30761. Epub 2019 Jun 25. PubMed PMID: 31081957; PubMed Central PMCID: PMC6851418.
  • Warner DR, Warner JB, Hardesty JE, Song YL, King TN, Kang JX, Chen CY, Xie S, Yuan F, Prodhan MAI, Ma X, Zhang X, Rouchka EC, Maddipati KR, Whitlock J, Li EC, Wang GP, McClain CJ, Kirpich IA. Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury. J Lipid Res. 2019 Dec;60(12):2034-2049. doi: 10.1194/jlr.RA119000200. Epub 2019 Oct 4. PubMed PMID: 31586017; PubMed Central PMCID: PMC6889711.
  • Vatsalya V, Hassan HZ, Kong M, Stangl BL, Schwandt ML, Schmidt-Teron VY, Verster JC, Ramchandani VA, McClain CJ. Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study. J Clin Med. 2019 Nov 12;8(11). pii: E1943. doi: 10.3390/jcm8111943. PubMed PMID: 31718086; PubMed Central PMCID: PMC6912317.
  • Zhao C, Liu L, Liu Q, Li F, Zhang L, Zhu F, Shao T, Barve S, Chen Y, Li X, McClain CJ, Feng W. Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. Mol Metab. 2019 Nov;29:145-157. doi: 10.1016/j.molmet.2019.08.020. Epub 2019 Sep 3. PubMed PMID: 31668386; PubMed Central PMCID: PMC6812038.