David S. K. Magnuson, Ph.D.

Photo of David Magnuson
  1. Friends for Michael Endowed Professor, Departments of Neurological Surgery, Anatomical Sciences & Neurobiology, and Biomedical Engineering

 

Phone: 502-852-6551; Fax: 502-852-5148

E-mail David Magnuson


Research Focus:

The research in my laboratory is focused on the neurons and pathways in the spinal cord that are responsible for locomotion, and on applying what we learn about locomotor systems to spinal cord injury and repair.

One of our primary investigations is focused on the long propriospinal neurons and pathways in the spinal cord that link the lumbar and cervical enlargements. These circuits are well-suited to participate in locomotion and are thought to mediate forelimb/hindlimb coordination in animals and upper-body/arm movement during walking and running in humans. We use a combination of approaches including electrophysiology and tract-tracing and both the in vitro neonatal rat brainstem/spinal cord preparation, and adult rats, in vivo. We are seeking to determine the roles played by specific descending and ascending pathways in locomotor activity in normal and spinal cord injured rats. The most recent results from this project suggest that white matter in the lateral and ventrolateral funiculus of the spinal cord may carry ascending and descending propriospinal axons that terminate in the cervical and lumbar enlargement, respectively. Many of these axons are located in the outermost rim of white matter and are spared following contusion spinal cord injuries, making them excellent potential targets for therapeutic approaches following spinal cord injury.

A second major project in my laboratory is aimed at gaining a better understanding of activity-based rehabilitation, one of the primary rehabilitation strategies used clinically, that usually takes the form of body-weight supported treadmill training. We are currently using four different approaches in animal models including swimming, shallow water walking, treadmill step training with body-weight support and a rat wheel-chair to reduce hindlimb movement after injury. Over the next several years we will be investigating the mechanisms underlying functional recovery following activity-based rehabilitation including the role(s) that cutaneous feedback, limb-loading, step-cycle number and frequency and timing and duration of training play in a successful rehabilitation program. We are working with Dr. Susie Harkema, the director of the NeuroRehabilitation Program at the Frazier Rehabilitation Institute to answer specific questions in the animal model that will assist with the development of novel clinical rehabilitation strategies.

In addition, we are working with the laboratories of Drs. Scott Whittemore, Susan Harkema, Jeffrey Petruska, and Richard Benton within KSCIRC, Dr. Michael Voor in Orthopedic Surgery and Dr. Radhika Vaishnav of the Department of Neurology at UofL, and Dr. Victor Song at Washington University.

Click to view all of Dr. kaelin's publications on PubMed

Key Publications:

Caudle KL, Atkinson DA, Brown EH, Donaldson K, Seibt E, Chea T, Smith E, Chung K, Shum-Siu A, Cron CC, Magnuson DS. Hindlimb Stretching Alters Locomotor Function After Spinal Cord Injury in the Adult Rat.Neurorehabil Neural Repair. 2014 Aug 8. pii: 1545968314543500. [Epub ahead of print]

Kim JH, Song SK, Burke DA, Magnuson DS. Comprehensive locomotor outcomes correlate to hyperacute diffusion tensor measures after spinal cord injury in the adult rat. Exp Neurol. 235: 188-196, 2012.

Caudle KL, Brown EH, Shum-Siu A, Burke DA, Magnuson TSG, Voor MJ, Magnuson DSK. Hindlimb immobilization in a wheelchair alters functional recovery following contusive spinal cord injury in the adult rat. Neurorehab and Neural Repair. 25: 729-39, 2011.

Cheng J, Magnuson DSK. Initiation of segmental locomotor-like activities by stimulation of ventrolateral funiculus in the neonatal rat. Exp Br Res. 214: 151-161, 2011.

Kuerzi J, Brown EH, Shum-Siu A, Siu A, Burke D, Morehouse J, Smith RR, Magnuson DSK.Task-specificity vs ceiling effect: Step-training in shallow water after spinal cord injury. Exp Neurol 224: 178-87. 2010.