Lisa K Ryan, PhD

 Lisa Kathleen Ryan, PhD

Associate Professor
Department of Oral Immunology & Infectious Diseases
501 S. Preston St., Room 263A
Louisville, KY 40292

Phone: (502) 852-9247
FAX: (502) 852-5572






Research Interests:
Viral induction and innate immunity of defensins, especially human beta-defensin-1 (hBD-1), studying HSV, HIV, influenza and SARS-CoV2.

Understanding immunomodulation of antimicrobial peptides by various environmental exposures, including vanadium and Vitamin D.

Development of anti-fungal and anti-viral drugs, which are based on antimicrobial peptide structure, on oral and respiratory infections in collaboration with Gill Diamond, Ph.D.

Key Review Articles:

RYAN, L.K., DIAMOND, G.  Modulation of human beta-defensin-1 production by viruses.  2017.
Viruses 9(6): pii: E153.  PMID: 28635669

DIAMOND, G., RYAN, L.K. Beta-defensins: what are they REALLY doing in the oral cavity? Oral Diseases, 17:628-635, 2011.  PMID: 21332602

DIAMOND, G., BECKLOFF, N., RYAN, LK.  Host defense peptides in the oral cavity and the lung: similarities and differences.  Journal of Dental Research, 87:915-927, 2008.  PMID: 18809744

DIAMOND, G., LEGARDA, D., RYAN, L.K. The innate immune response of the respiratory epithelium. Immunological Reviews, 173:27-38, 2000.  PMID: 10719665

Key Book Chapters:

 Ozone.  In:  Cohen M, Zelikoff J, Schlesinger R (eds.).  Pulmonary Immunotoxicology. Kluwer Publishing Co., NY; pp. 301-336, 2000.

LAUBE, D.M., YIM, S., RYAN, L.K., KISICH, K.O., DIAMOND, G.  Antimicrobial peptides in the airway.  In: Antimicrobial Peptides in Human Diseases.  W. Shafer, ed., Current Topics in Microbiology and Immunology, 306:155-184, 2006.  PMID: 16909921

RYAN, L.K.  Vanadium pentoxide effects on the lung.  In: Uversky V, Kretsinger RH, and Permyakov EA (ed.) Encyclopedia of Metalloproteins.  Springer, NY, NY; pp. 2324- 2330, 2013.

CHOWDHURY, M.H., DIAMOND, G., RYAN, L.K.  Synergy of Antimicrobial Peptides.  In:  Wang G. (ed).  Antimicrobial Peptides, 2nd Edition:  Discovery, Design and Novel Therapeutic Strategies.  CABI, Wallingford, Oxfordshire, U.K.; pp. 188-201, 2017.

RYAN, L.K.  Innate Immunity and the Cancer Microenvironment.  In:  Mukherjee, B. (ed.)  Novel Molecular Onco-targets and Nano-oncotherapeutics.  2021.  Cambridge Scholars Publishing, Ltd., UK;  pp. 2-10, 2022.


Up to Date Original Research Publications:

Complete List of Published Work in MyBibliography: