Donghoon Chung, Ph.D.

Current Lab Members
Andrew Skidmore - PhD Student
Scott Adcock - Research Technician

Research Interest
The research focus of Chung lab is to understand the biology of viruses that infect brain (i.e., neurotropic viruses). The primary focus is on medically important positive strand RNA viruses such as Venezuelan equine encephalitis virus, Chikungunya virus, West Nile virus and Zika virus. During the last six years, the lab has discovered two novel antiviral compounds that inhibit these viruses with specific mechanisms of actions.

In order to develop these compounds as a preclinical therapeutic candidate, the lab is investigating 1) the antiviral mechanism of actions of the compounds at the molecular level and 2) the evaluation of in vivo antiviral activity of the compounds. This effort is supported by an R01 grant by NIH.

The lab is also studying how neurotropic viruses interact with the brain cells. With collaboration with Dr. Hetman’s group, the lab is studying how neurotropic virus invades the brains and what biological impacts neurotropic viruses make to the brain cells. The lab uses a variety of new in vivo and in vitro models to study the interaction between the neural cells and neurotropic viruses. 

Selected Publications

  1. Adcock, R.S., Y.K. Chu, J.E. Golden, and D.H. Chung*, Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay. Antiviral research, 2016: p. 47-56. PMCID: 27919709
  2. Chung*, J.E. Golden,  R.S. Adcock, C.E. Schroeder,Y-K. Chu, J.B. Sotsky, D.E. Cramer, P.M. Chilton, C. Song, M. Anantpadma, R.A. Davey, A.I. Prodhan,  X. Yin, and X. Zhang Discovery of a broad-spectrum antiviral compound that inhibits pyrimidine biosynthesis and establishes a type 1 interferon-independent antiviral state. Antimicrobial Agent Chemotherapy. 2016(8) p4552-62. PMID : 27185801
  3. Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Chad E. Schroeder, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA. Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2. PLoS pathogens, 2014(6): p. e1004213. PMCID: 24967809
  4. Chung, D.H., A. Vastermark, J.V. Camp, R. McAllister, S.K. Remold, Y.K. Chu, C. Bruder, and C.B. Jonsson, The murine model for Hantaan virus-induced lethal disease shows two distinct paths in viral evolutionary trajectory with and without ribavirin treatment. Journal of virology, 2013(20): p. 10997-1007. PMCID: 23903835
  5. Chung DH*, Jonsson CB, Maddox C, McKellip SN, Moore BP, Heil M, White EL, Ananthan S, Li Q, Feng S, Rasmussen L. HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity. Molecules (Basel, Switzerland). 2010(3):1690-704. PMCID: 20336008