Donghoon Chung, Ph.D.

Donghoon Chung, Ph.D.

Research Interest
The research focus of Chung lab is to understand the biology of viruses that infect brain (i.e., neurotropic viruses). The primary focus is on medically important positive strand RNA viruses such as Venezuelan equine encephalitis virus, Chikungunya virus, West Nile virus and Zika virus. During the last six years, the lab has discovered two novel antiviral compounds that inhibit these viruses with specific mechanisms of actions.

In order to develop these compounds as a preclinical therapeutic candidate, the lab is investigating 1) the antiviral mechanism of actions of the compounds at the molecular level and 2) the evaluation of in vivo antiviral activity of the compounds. This effort is supported by an R01 grant by NIH.

The lab is also studying how neurotropic viruses interact with the brain cells. With collaboration with Dr. Hetman’s group, the lab is studying how neurotropic virus invades the brains and what biological impacts neurotropic viruses make to the brain cells. The lab uses a variety of new in vivo and in vitro models to study the interaction between the neural cells and neurotropic viruses. 

Selected Publications

  1. Chung, D.H., C.B. Jonsson, N.A. Tower, Y.K. Chu, E. Sahin, J.E. Golden, J.W. Noah, C.E. Schroeder, J.B. Sotsky, M.I. Sosa, D.E. Cramer, S.N. McKellip, L. Rasmussen, E.L. White, C.S. Schmaljohn, J.G. Julander, J.M. Smith, C.M. Filone, J.H. Connor, Y. Sakurai, and R.A. Davey, Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. PLoS pathogens, 2014(6): p. e1004213. PMCID: 24967809
  2. Chung, D.H., A. Vastermark, J.V. Camp, R. McAllister, S.K. Remold, Y.K. Chu, C. Bruder, and C.B. Jonsson, The murine model for Hantaan virus-induced lethal disease shows two distinct paths in viral evolutionary trajectory with and without ribavirin treatment. Journal of virology, 2013(20): p. 10997-1007. PMCID: 23903835
  3. Chung, D.H., B.P. Moore, D.S. Matharu, J.E. Golden, C. Maddox, L. Rasmussen, M.I. Sosa, S. Ananthan, E.L. White, F. Jia, C.B. Jonsson, and W.E. Severson, A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Virol J, 2013. 10: p. 19. PMCID: PMC3621174
  4.  Moore, B.P., D.H. Chung, D.S. Matharu, J.E. Golden, C. Maddox, L. Rasmussen, J.W. Noah, M.I. Sosa, S. Ananthan, N.A. Tower, E.L. White, F. Jia, T.E. Prisinzano, J. Aube, C.B. Jonsson, and W.E. Severson, (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. Journal of Medicinal Chemistry, 2012(20): p. 8582-7. PMCID: PMC3506029
  5. Chung, D.H., C.B. Jonsson, C. Maddox, S.N. McKellip, B.P. Moore, M. Heil, E.L. White, S. Ananthan, Q. Li, S. Feng, and L. Rasmussen, HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity. Molecules (Basel, Switzerland), 2010(3): p. 1690-704. PMCID: 20336008