Shuang Liang, PhD
Assistant Professor Term
Oral Health and Systemic Disease Research
Periodontal disease is a chronic inflammatory disease characterized by gingival inflammation and periodontal bone loss. Invasion of etiological bacteria into periodontal tissues induces host responses which cause lateral tissue destruction and bone resorption. Helper T cell is pivotal in the establishment and optimization of adaptive immunity, therefore an important component of host response. Our research interest is to investigate host T cell responses induced by the important periodontitis etiological pathogen Porphyromonas gingivalis (Pg). Using a series of in vitro assays and in vivo models, we aim to elucidate the function of Pg-induced T cell response on periodontal disease development. Our goal is to determine the signaling pathways that promote differentiation of interested T cell subsets, and identify potential therapeutic targets for periodontal diseases.
Shuang Liang, Pascale Alard, Yuan Zhao, Sherry L. Clark, Sarah Parnell and Michele M. Kosiewicz. CD4+CD25- cells conversion into CD4+CD25+ regulatory T cells in vivo requires B7 co-stimulation, but not the thymus. Journal of Experimental Medicine, 201(1), 127-137, 2005
Shuang Liang, Min Wang, Kathy Triantafilou, Martha Triantafilou, Hesham F. Nawar, Michael W. Russell, Terry D. Connell and George Hajishengallis. The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2. The Journal of Immunology, 178(8), 4811-4819, 2007
Shuang Liang, Min Wang, Richard I. Tapping, Vitaly Stepensky, Hesham F. Nawar, Martha Triantafilou, Kathy Triantafilou, Terry D. Connell, and George Hajishengallis. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. Journal of Biological Chemistry., 282(10):7532-7542, 2007
Shuang Liang, Kavita B. Hosur, Shanyun Lu, Hesham F. Nawar, Benjamin R. Weber, Richard I. Tapping, Terry D. Connell, and George Hajishengallis. Mapping of a Microbial Protein Domain Involved in Binding and Activation of the TLR2/TLR1 Heterodimer. The Journal of Immunology, 182(5):2978-85, 2009
Shuang Liang, Kavita B. Hosur, Hesham F. Nawar, Michael W. Russell, Terry D. Connell, and George Hajishengallis. In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine. 27(32):4302-4308, 2009
Shuang Liang, Hisanori Domon, Kavita B. Hosur, Min Wang and George Hajishengallis. Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mechanisms of Ageing and Development,130(8):538-546, 2009
Shuang Liang, Kavita B. Hosur, Hisanori Domon, and George Hajishengallis. Periodontal inflammation and bone loss in aged mice. Journal of Periodontal Research,45(4):574-578. 2010.
Min Wang, Jennifer L. Krauss, Hisanori Domon, Kavita B. Hosur, Shuang Liang, Paola Magotti, Martha Triantafilou, Kathy Triantafilou, John D. Lambris, and George Hajishengallis. Microbial hijacking of complement-toll-like receptor crosstalk. Science Signaling, 3(109): ra11, 2010
Shuang Liang, Jennifer L. Krauss, Hisanori Domon, Megan L. McIntosh, Kavita B. Hosur, Hongchang Qu, Fenge Li, Apostolia Tzekou, John D. Lambris, and George Hajishengallis. The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss. Journal of Immunology, 186(2):869-877. 2011.