Program Schedule
Saturday, June 1, 2024
8:00AM | Registration & Breakfast |
8:45AM |
Opening & Welcome J. Christopher States, Ph.D., University of Louisville |
9:00AM |
1st Keynote Address Karen Vasquez, Ph.D., University of Texas at Austin “Novel Mechanisms of Genetic Instability in Cancer” |
9:30AM |
Platform Session 1 Session Chair: J. Christopher States, Ph.D., University of Louisville Ankita Chadda, Ph.D., Washington University in Saint Louis “Structure of the active dimeric form of UvrD-family helicase” |
9:45AM | Justin Ling, Ph.D., University of Kansas Medical Center “Consequences of Ribonucleotides in Telomeres” |
10:00AM | Fathima Mohamad Rukshana Ramshan, Ph.D., Wayne State University “Uracilome of B cells undergoing class-switch recombination” |
10:15AM | Poonam Roshan, Ph.D., Saint Louis University “Deciphering the structure-function relations of the RPA phosphocode” |
10:30AM | Break |
11:00AM |
Platform Session 2 Session Chair: Alexandra Nail, Ph.D., University of Louisville Ning Tsao, Ph.D., Washington University School of Medicine in St. Louis “YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks” |
11:15AM | Myna Adhikari, University of Illinois College of Medicine “Induction of Mutations by Human Topoisomerase IIβ Enzyme” |
11:30AM | Zach Frevert, University of Iowa “Investigating Novel Activities of Polymerase Iota Utilizing Time-Lapse Crystallography” |
11:45AM | Denis Firsanov, Ph.D., University of Rochester “DNA repair and anti-cancer mechanisms in the long-lived bowhead whale” |
12:00PM | Abhishikt David Solomon, University of North Coralina at Chapel Hill “Gamma-tubulin Mediates DNA Double Strand Break Repair” |
12:15PM | Lunch |
1:00PM |
2nd Keynote Address Jeremy Stark, Ph.D., City of Hope “Regulation of chromosomal break repair outcomes” |
1:30PM |
Platform Session 3 Session Chair: Mayukh Banerjee, Ph.D., University of Louisville Yibo Luo, Ph.D., University of Toledo “Exploring cellular paradoxical responses to DNA damage: A novel strategy for overcoming cancer drug resistance” |
1:45PM | Himadri Biswas, Ph.D., University of Toledo “Accumulation of ATR-tBid complex at mitochondria is a hallmark of cellular senescence and aging, implicated in age-associated spontaneous tumorigenesis via apoptosis evasion” |
2:00PM | Kristen Brenner, Ph.D., University of Michigan “POT1 binds the double-stranded-single-stranded DNA junction within telomeres to prevent a DNA damage response at the chromosome end” |
2:15PM | Mae Alexandra Carpenter, Ph.D., Wright State University “Cell-free UV photoproduct-containing DNA can be taken up by bystander cells and induce DNA damage response” |
2:30PM | Matthew R. Jordan, Ph.D., Indiana University School of Medicine “The Effect of Replication Protein A Inhibition and Post-Translational Modification on ATR Kinase Signaling and Replication Fork Dynamics” |
2:45PM | Paul Pease, Ph.D., Lumicks “From Molecule to Mechanism: DNA Repair through the Lens of Single-Molecule Techniques” |
3:00PM | Posters |
6:00PM | Dinner |
Sunday, June 2, 2024
8:00AM | Breakfast |
8:45AM |
Welcome J. Christopher States, Ph.D., University of Louisville |
9:00AM |
3rd Keynote Address Bevin Engelward, Sc.D., MIT “In vivo Analysis of DNA Damage, Repair, and Mutations in the Context of Environmental Health” |
9:30AM |
Platform Session 4 Session Chair: Mats Ljungman, Ph.D., University of Michigan Alexandra Nail, Ph.D., University of Louisville “Chronic Heavy Metal Exposure Disrupts the DNA Damage Response to Promote Carcinogenesis” |
9:45AM | Dylan Fingerman, Washington University School of Medicine “Molecular Mechanisms of Tolerance of DNA Damage caused by APOBEC3A During Replication” |
10:00AM | David Beier, University of Michigan “The Biochemical Impact of the LIG1 K845N Mutant on the Fidelity of DNA Ligation” |
10:15AM | Gouttia Odjo, University of North Coralina at Chapel Hill “MASTL Kinase Modulates DNA Interstrand Crosslinking Repair and Cisplatin Resistance” |
10:30AM | Break |
11:00AM |
Platform Session 5 Session Chair: Mats Ljungman, Ph.D., University of Michigan Eloise Dray, Ph.D. “Impacts of the Phosphorylation of RAD51 on its function at DSBs and replication forks” |
11:15AM | Eva Goellner, Ph.D., University of Kentucky “Enhancing Immunotherapy by Modulating MLH1 Phosphorylation with ABL Kinase Inhibitors” |
11:30AM | Maria Mills, Ph.D., University of Missouri “Single molecule measurements of the effect of p44 on XPD helicase activity” |
11:45AM | Isabelle Miousse, Ph.D., University of Arkansas for Medical Sciences “Reducing exogenous methionine sensitizes KRAS mutant colorectal cells to radiation” |
12:00PM | Awards |
12:15PM | Lunch & Closing |