Program Schedule — Center for Integrative Environmental Health Sciences

Program Schedule

Saturday, June 1, 2024

8:00AM	Registration & Breakfast
8:45AM	Opening & Welcome J. Christopher States, Ph.D., University of Louisville
9:00AM	1st Keynote Address Karen Vasquez, Ph.D., University of Texas at Austin “Novel Mechanisms of Genetic Instability in Cancer”
9:30AM	Platform Session 1 Session Chair: J. Christopher States, Ph.D., University of Louisville Ankita Chadda, Ph.D., Washington University in Saint Louis “Structure of the active dimeric form of UvrD-family helicase”
9:45AM	Justin Ling, Ph.D., University of Kansas Medical Center “Consequences of Ribonucleotides in Telomeres”
10:00AM	Fathima Mohamad Rukshana Ramshan, Ph.D., Wayne State University “Uracilome of B cells undergoing class-switch recombination”
10:15AM	Poonam Roshan, Ph.D., Saint Louis University “Deciphering the structure-function relations of the RPA phosphocode”
10:30AM	Break
11:00AM	Platform Session 2 Session Chair: Alexandra Nail, Ph.D., University of Louisville Ning Tsao, Ph.D., Washington University School of Medicine in St. Louis “YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks”
11:15AM	Myna Adhikari, University of Illinois College of Medicine “Induction of Mutations by Human Topoisomerase IIβ Enzyme”
11:30AM	Zach Frevert, University of Iowa “Investigating Novel Activities of Polymerase Iota Utilizing Time-Lapse Crystallography”
11:45AM	Denis Firsanov, Ph.D., University of Rochester “DNA repair and anti-cancer mechanisms in the long-lived bowhead whale”
12:00PM	Abhishikt David Solomon, University of North Coralina at Chapel Hill “Gamma-tubulin Mediates DNA Double Strand Break Repair”
12:15PM	Lunch
1:00PM	2nd Keynote Address Jeremy Stark, Ph.D., City of Hope “Regulation of chromosomal break repair outcomes”
1:30PM	Platform Session 3 Session Chair: Mayukh Banerjee, Ph.D., University of Louisville Yibo Luo, Ph.D., University of Toledo “Exploring cellular paradoxical responses to DNA damage: A novel strategy for overcoming cancer drug resistance”
1:45PM	Himadri Biswas, Ph.D., University of Toledo “Accumulation of ATR-tBid complex at mitochondria is a hallmark of cellular senescence and aging, implicated in age-associated spontaneous tumorigenesis via apoptosis evasion”
2:00PM	Kristen Brenner, Ph.D., University of Michigan “POT1 binds the double-stranded-single-stranded DNA junction within telomeres to prevent a DNA damage response at the chromosome end”
2:15PM	Mae Alexandra Carpenter, Ph.D., Wright State University “Cell-free UV photoproduct-containing DNA can be taken up by bystander cells and induce DNA damage response”
2:30PM	Matthew R. Jordan, Ph.D., Indiana University School of Medicine “The Effect of Replication Protein A Inhibition and Post-Translational Modification on ATR Kinase Signaling and Replication Fork Dynamics”
2:45PM	Paul Pease, Ph.D., Lumicks “From Molecule to Mechanism: DNA Repair through the Lens of Single-Molecule Techniques”
3:00PM	Posters
6:00PM	Dinner

Sunday, June 2, 2024

8:00AM	Breakfast
8:45AM	Welcome J. Christopher States, Ph.D., University of Louisville
9:00AM	3rd Keynote Address Bevin Engelward, Sc.D., MIT “In vivo Analysis of DNA Damage, Repair, and Mutations in the Context of Environmental Health”
9:30AM	Platform Session 4 Session Chair: Mats Ljungman, Ph.D., University of Michigan Alexandra Nail, Ph.D., University of Louisville “Chronic Heavy Metal Exposure Disrupts the DNA Damage Response to Promote Carcinogenesis”
9:45AM	Dylan Fingerman, Washington University School of Medicine “Molecular Mechanisms of Tolerance of DNA Damage caused by APOBEC3A During Replication”
10:00AM	David Beier, University of Michigan “The Biochemical Impact of the LIG1 K845N Mutant on the Fidelity of DNA Ligation”
10:15AM	Gouttia Odjo, University of North Coralina at Chapel Hill “MASTL Kinase Modulates DNA Interstrand Crosslinking Repair and Cisplatin Resistance”
10:30AM	Break
11:00AM	Platform Session 5 Session Chair: Mats Ljungman, Ph.D., University of Michigan Eloise Dray, Ph.D. “Impacts of the Phosphorylation of RAD51 on its function at DSBs and replication forks”
11:15AM	Eva Goellner, Ph.D., University of Kentucky “Enhancing Immunotherapy by Modulating MLH1 Phosphorylation with ABL Kinase Inhibitors”
11:30AM	Maria Mills, Ph.D., University of Missouri “Single molecule measurements of the effect of p44 on XPD helicase activity”
11:45AM	Isabelle Miousse, Ph.D., University of Arkansas for Medical Sciences “Reducing exogenous methionine sensitizes KRAS mutant colorectal cells to radiation”
12:00PM	Awards
12:15PM	Lunch & Closing