John W. Eaton, Ph.D.


B.A., Florida State University, 1963
M.A., University of Florida, 1964
M.S., University of Michigan, 1966
Ph.D., University of Michigan, 1969
M.D.hc, University of Linkoping, Sweden, 2001

Curriculum Vitae

Current Positions:

Professor Emeritus, Departments of Medicine, and Pharmacology & Toxicology, University of Louisville, Louisville, KY

Contact Information:

Kosair Charities Clinical & Translational Research Building
University of Louisville
505 South Hancock Street
Louisville, KY 40202
Phone 502-852-1075
Fax 502-852-3661


Research Description:

Eaton does research on biological oxidation/reduction reactions, which are important in inflammation and carcinogenesis.  His laboratory also is active in studies of mitochondria, which are, in normal cells, the major source of energy.  A current interest is in changes in mitochondrial metabolism in various types of cancer.  Eaton and his colleagues are pursuing investigations into an anti-cancer vaccine made of embryonic stem cells.  In mice, this vaccine prevents the outgrowth of transplantable and carcinogen-induced lung cancer.  Finally, his laboratory also is investigating the importance of lysosomes - small digestive organelles present in all cells - in the process of cell death.

Literature Cited (Selected Peer-Reviewed Publications from 2000):

Early investigations of the nature and origins of congenital and acquired hemolytic anemia

  • Eaton JW., Brewer GJ.  Red cell ATP and malaria infection.  Nature 1969 Apr 28;222(5191):389-90.  PMID: 4976567.
  • Eaton JW, Kolpin CF, Swofford HS, Kjellstrand CM, Jacob HS.  Chlorinated urban water: A cause of dialysis-induced hemolytic anemia.  Science 1973 Aug 3;181(4098):463-4.  PMID: 4718115.
  • Eaton JW, Skelton TD, Swofford HS, Kolpin CF, Jacob HS.  Elevated erythrocyte calcium concentration in sickle cell disease.  Nature 1973 Nov 9;246(5428):105-6.  PMID: 4585849.
  • Hebbel RP, Yamada O, Moldow CF, Jacob HS, White JG, Eaton JW.  Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease.  Journal of Clinical Investigation 1980 Jan;65:154-60, doi: 10.1172/JCI109646.  PMID: 7350195.  PMCID: PMC371350.

Mechanisms of bacterial virulence

  • Confer DL, Eaton JW.  Phagocyte impotence caused by an invasive bacterial adenylate cyclase.  Science 1982 Sep 3;217:948-50.  PMID: 6287574.
  • Ma M, Eaton JW.  Multicellular oxidant defense in unicellular organisms.  Proc Natl Acad Sci USA 1992 Sep 1;89:7924-8.  PMID: 1518815.  PMCID: PMC49827.
  • Telang S, Vimr E, Mahoney JR, Law I, Lundqvist-Gustafsson H, Qian M, Eaton JW.  Strain-specific iron-dependent virulence in Escherichia coli.  J Infect Dis 2001 2001 Jul 15;184:159-65.  PMID: 11424012.

Oxygen and oxidants in disease processes

  • Eaton JW, Skelton TD, Berger E.  Survival at extreme altitude: Protective effect of increased hemoglobin-oxygen affinity.  Science 1974 Feb 22;1834126):743-4.  PMID: 4821240.
  • Hebbel RP, Eaton JW, Kronenberg RS, Zanjani ED, Moore LG, Berger EM.  Human llamas: Adaptation to altitude in subjects with high hemoglobin oxygen affinity.  J Clin Invest 1978 Sep;62:593-600.  doi: 10.1172/JCI1909165.  PMID: 29054, PMCID: PMC371804.
  • Branda RF, Eaton JW.  Skin color and nutrient photolysis: An evolutionary hypothesis.  Science 1978 Aug 18;201:625-6.  PMID: 675247.
  • Fairfield AS, Meshnick SR, Eaton JW.  Malarial parasites adopt host cell superoxide dismutase.  Science 1983 Aug 18;221(4612):764-6, PMID: 6348944.
  • Goth L, Eaton JW.  Hereditary catalase deficiencies and increased risk of type II diabetes.  Lancet2000 Nov 25;356(9244):1820-1.  PMID: 11117918.

Inflammatory responses to biomaterials

  • Tang L, Eaton, JW.  Fibrin(ogen) mediates acute inflammatory responses to biomaterials. J Exp Med 1993 Dec 1:178(6):2147-56.  PMID: 8245787.  PMCID:  PMC2191295.
  • Tang L, Ugarova TP, Plow EF, Eaton JW.  Molecular determinants of acute inflammatory responses to biomaterials. J Clin Invest 1996 Mar 1:97(5):1329-34.  doi:  10.1172/JCI118549.  PMID:  8636446.  PMCID:  PMC507187.
  • Tang L, Jennings TA, Eaton JW.  Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc Natl Acad Sci USA 1998 Jul 21;95(15):8841-6.  PMID:  9671766.  PMCID:  PMC21164.
  • Tang L, Eaton JW.  Natural responses to unnatural materials: A molecular mechanism for foreign body reactions.  Molec Med 1999 Jun;5(6):L351-8.  PMID: 10415159.  PMCID:  PMC2230429.
  • Li J, Gao X, Qian M, Eaton JW.  Mitochondrial metabolism underlies hyperoxic cell damage.  Free Radic Biol Med 2004 Jun 1;36(11):1460-70.  PMID: 15135183.
  • Campian JL, Gao X, Qian M, Eaton JW.  Cytochrome C oxidase activity and oxygen tolerance.  J Biol Chem 2007 Apr 27;282(17):12430-8.  doi: 10.107/jbc.M604545200.  PMID: 17303578.  [ ]

Possibility of developing a prophylactic vaccine to prevent the development of cancer

  • Yaddanapudi K, Mitchell RA, Putty K, Willer SS, Sharma RK, Yan J, Haribabu B, Eaton JW.  Vaccination with embryonic stem cells protects against lung cancer: Is a broad-spectrum prophylactic vaccine against cancer possible?  PLoS One 2012 7(7):e42289.  doi: 10.1371/journal.pone.0042289.  Epub 2012 Jul 31.  PMID:  22860107.  PMCID: PMC3409174.
  • Yaddanapudi K, Li C, Eaton JW.  Vaccination with induced pluripotent stem cells confers protection against cancer. (Editorial)  Stem Cell Investigation 2018;5 (in press).

PubMed Information