John W. Eaton, Ph.D.

Education:

B.A., Florida State University, 1963
M.A., University of Florida, 1964
M.S., University of Michigan, 1966
Ph.D., University of Michigan, 1969
M.D.hc, University of Linkoping, Sweden, 2001

Curriculum Vitae

Current Positions:

Professor Emeritus, Departments of Medicine, and Pharmacology & Toxicology, University of Louisville, Louisville, KY

Contact Information:

Kosair Charities Clinical & Translational Research Building
University of Louisville
505 South Hancock Street
Louisville, KY 40202
Phone 502-852-1075
Fax 502-852-3661

Email EatonRedox@aol.com

Research Description:

Eaton does research on biological oxidation/reduction reactions, which are important in inflammation and carcinogenesis.  His laboratory also is active in studies of mitochondria, which are, in normal cells, the major source of energy.  A current interest is in changes in mitochondrial metabolism in various types of cancer.  Eaton and his colleagues are pursuing investigations into an anti-cancer vaccine made of embryonic stem cells.  In mice, this vaccine prevents the outgrowth of transplantable and carcinogen-induced lung cancer.  Finally, his laboratory also is investigating the importance of lysosomes - small digestive organelles present in all cells - in the process of cell death.

Literature Cited (Selected Peer-Reviewed Publications from 2000):

Early investigations of the nature and origins of congenital and acquired hemolytic anemia

  • Eaton JW., Brewer GJ.  Red cell ATP and malaria infection.  Nature 1969 Apr 28;222(5191):389-90.  PMID: 4976567.
  • Eaton JW, Kolpin CF, Swofford HS, Kjellstrand CM, Jacob HS.  Chlorinated urban water: A cause of dialysis-induced hemolytic anemia.  Science 1973 Aug 3;181(4098):463-4.  PMID: 4718115.
  • Eaton JW, Skelton TD, Swofford HS, Kolpin CF, Jacob HS.  Elevated erythrocyte calcium concentration in sickle cell disease.  Nature 1973 Nov 9;246(5428):105-6.  PMID: 4585849.
  • Hebbel RP, Yamada O, Moldow CF, Jacob HS, White JG, Eaton JW.  Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease.  Journal of Clinical Investigation 1980 Jan;65:154-60, doi: 10.1172/JCI109646.  PMID: 7350195.  PMCID: PMC371350.


Mechanisms of bacterial virulence

  • Confer DL, Eaton JW.  Phagocyte impotence caused by an invasive bacterial adenylate cyclase.  Science 1982 Sep 3;217:948-50.  PMID: 6287574.
  • Ma M, Eaton JW.  Multicellular oxidant defense in unicellular organisms.  Proc Natl Acad Sci USA 1992 Sep 1;89:7924-8.  PMID: 1518815.  PMCID: PMC49827.
  • Telang S, Vimr E, Mahoney JR, Law I, Lundqvist-Gustafsson H, Qian M, Eaton JW.  Strain-specific iron-dependent virulence in Escherichia coli.  J Infect Dis 2001 2001 Jul 15;184:159-65.  PMID: 11424012.


Oxygen and oxidants in disease processes

  • Eaton JW, Skelton TD, Berger E.  Survival at extreme altitude: Protective effect of increased hemoglobin-oxygen affinity.  Science 1974 Feb 22;1834126):743-4.  PMID: 4821240.
  • Hebbel RP, Eaton JW, Kronenberg RS, Zanjani ED, Moore LG, Berger EM.  Human llamas: Adaptation to altitude in subjects with high hemoglobin oxygen affinity.  J Clin Invest 1978 Sep;62:593-600.  doi: 10.1172/JCI1909165.  PMID: 29054, PMCID: PMC371804.
  • Branda RF, Eaton JW.  Skin color and nutrient photolysis: An evolutionary hypothesis.  Science 1978 Aug 18;201:625-6.  PMID: 675247.
  • Fairfield AS, Meshnick SR, Eaton JW.  Malarial parasites adopt host cell superoxide dismutase.  Science 1983 Aug 18;221(4612):764-6, PMID: 6348944.
  • Goth L, Eaton JW.  Hereditary catalase deficiencies and increased risk of type II diabetes.  Lancet2000 Nov 25;356(9244):1820-1.  PMID: 11117918.


Inflammatory responses to biomaterials

  • Tang L, Eaton, JW.  Fibrin(ogen) mediates acute inflammatory responses to biomaterials. J Exp Med 1993 Dec 1:178(6):2147-56.  PMID: 8245787.  PMCID:  PMC2191295.
  • Tang L, Ugarova TP, Plow EF, Eaton JW.  Molecular determinants of acute inflammatory responses to biomaterials. J Clin Invest 1996 Mar 1:97(5):1329-34.  doi:  10.1172/JCI118549.  PMID:  8636446.  PMCID:  PMC507187.
  • Tang L, Jennings TA, Eaton JW.  Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc Natl Acad Sci USA 1998 Jul 21;95(15):8841-6.  PMID:  9671766.  PMCID:  PMC21164.
  • Tang L, Eaton JW.  Natural responses to unnatural materials: A molecular mechanism for foreign body reactions.  Molec Med 1999 Jun;5(6):L351-8.  PMID: 10415159.  PMCID:  PMC2230429.
  • Li J, Gao X, Qian M, Eaton JW.  Mitochondrial metabolism underlies hyperoxic cell damage.  Free Radic Biol Med 2004 Jun 1;36(11):1460-70.  PMID: 15135183.
  • Campian JL, Gao X, Qian M, Eaton JW.  Cytochrome C oxidase activity and oxygen tolerance.  J Biol Chem 2007 Apr 27;282(17):12430-8.  doi: 10.107/jbc.M604545200.  PMID: 17303578.  [ http://www.jbc.org/content/282/17/12430.long ]


Possibility of developing a prophylactic vaccine to prevent the development of cancer

  • Yaddanapudi K, Mitchell RA, Putty K, Willer SS, Sharma RK, Yan J, Haribabu B, Eaton JW.  Vaccination with embryonic stem cells protects against lung cancer: Is a broad-spectrum prophylactic vaccine against cancer possible?  PLoS One 2012 7(7):e42289.  doi: 10.1371/journal.pone.0042289.  Epub 2012 Jul 31.  PMID:  22860107.  PMCID: PMC3409174.
  • Yaddanapudi K, Li C, Eaton JW.  Vaccination with induced pluripotent stem cells confers protection against cancer. (Editorial)  Stem Cell Investigation 2018;5 (in press).

PubMed Information