Claudio Maldonado

University of Louisville, 1994

My general research interests are in composite tissue transplantation (CTA) and cardiovascular research.  In CTA, my focus has been on developing novel therapies that protect the endothelial barrier from ischemia/reperfusion injury following tissue transplantation. My laboratory has developed a novel technology that rapidly incorporates therapeutic molecules on the surface of the endothelium to protect it from being injured after transplantation.  One application of this technology consists of delivering anti-complement or anti-thrombotic therapies to protect grafts from ischemia/reperfusion induced damage. My research interest in cardiovascular research has been on cardiac electrophysiology and arrythmogenesis. Currently I'm collaborating with Dr. Tyagi to examine a novel arrythmogenic mechanisms induced in patients suffering from hyperhomocysteinemia.

  1. Li Z, Wang YH, Maldonado C, Kupersmith J. Role of junctional zone cells between Purkinje fibres and ventricular muscle in arrhythmogenesis. Cardiovasc Res 28:1277-84, 1994.
  2. Singer I, Goldsmith J, Maldonado C. Electrode surface area is an important variable for defibrillation. Pacing Clin Electrophysiol 18:233-236, 1995.
  3. Maldonado C, Talley JD, Mayfield-Stokes S, Leesar M, Shih A, Kalya A. Exogenous fibronectin to prevent neointimal hyperplasia after balloon angioplasty. J Invas Cardiol 8:107-112, 1996.
  4. Maldonado C, Li Z, Wead WB, Szabo T, Kupersmith J. Mechanisms of triggered activity induction at the border zone of normal and abnormal cardiac tissue. J Electrocardiol 29:309-318, 1996.
  5. Auchampach JA, Rizvi A, Qiu Y, Tang XL, Maldonado C, Teschner S, Bolli R. Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5’-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. Circ Res 80:800-806, 1997.
  6. Maldonado C, Qiu Y, Tang XL, Cohen MV, Auchampach J, Bolli R. Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits. A J Physiol 273:H1324-1332, 1997.
  7. Maldonado C, Stadelmann WK, Ramirez S, Quan EE, Barker JH. Preconditioning of latissimus dorsi muscle flaps with monophosphoryl lipid A. Plast Reconstr Surg 111:267-74, 2003.
  8. Prabhune KA, Gorantla VS, Perez-Abadia G, Francois C, Vossen M, Laurentin-Perez LA, Breidenbach WC, Anderson GL, Pidwell DJ, Barker JH, Maldonado C. Composite tissue allotransplantation in chimeric hosts Part II. A clinically feasible protocol to induce Tolerance in a rat model. Transplantation 76(11):1548-1555, 2003.
  9. Quan EE, Ramirez S, Tecimer T, Grossi FV, Barker JH, Maldonado C. Late phase Ischemic preconditioning in skeletal muscle: Is the phenomenon protective? Microsurgery 24:151-156, 2004.
  10. Brouha PCR , Perez-Abadia G, Francois, CG, Laurentin-Perez LA , Gorantla V, Vossen M, , Tai C, Pidwell DJ, , Anderson G, Stadelmann WK, Hewitt C, Kon M, Barker JH, Maldonado C. Lymphadenctomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts. Transplantion Int 17:341-350, 2004.
  11. Vossen, M., Edelstein J, Majzoub RK., Maldonado C, Ray M, Perez-Abadia GA, Voor MJ., Orhun, H., Tecimer, T., Fraancois, C., Kon M., Barker JH. Bone Quality and Healing in a Swine Vascularized Bone Allotransplantation Model Using Cyclosporin-Based Immunosuppression Therapy. Plast. Reconstr. Surg. 115: 529, 2005.
  12. Harralson T, Grossi F, Quan EE, Tecimer T, Perez-Abadia G, Anderson GL, Barker JH, Maldonado C. Ischemic preconditioning of skeletal muscle: Duration of late phase protection. Ann Plast Surg. 55:216-222, 2005.
  13. Francois CG, Brouha P, Laurentin-Perez LA, Perez-Abadia G, Grossi FV, Barker JH, Hewitt CW, Pidwell DJ, Kon M, Ramsamooj R, Maldonado C. Vascularized Lymph Node Transplantation induced Graft-Versus-Host Disease in Chimeric Hosts. Transplantation 81: 1435-1441, 2006.
  14. Brouha P, Naidu D, Cunningham M, Furr A, Majzoub RK, Grossi FV, Francois CG, Maldonado C, Banis JC, Martinez S, Perez-Abadia G, Wiggins O, Kon M, Barker JH. Risk Acceptance in Composite Tissue Allotransplantation reconstructive procedures. Microsurgery 26:144-150, 2006.
  15. Cottrell BL, Perez-Abadia G, Onifer SM, Magnuson DS, Burke DA, Grossi FV, Francois CG, Barker JH, Maldonado C. Neuroregeneration in composite tissue allografts: effect of low dose FK506 and mycophenolate mofetil immunotherapy. Plast Reconstr Surg 118(3): 615-23, 2006.
  16. Rosenberger D, Moshal KS, Kartha GK, Tyagi N, Sen U, Lominadze D, Maldonado C, Roberts AM, Tyagi SC. Arrhythmia and Neuronal/Endothelial Myocyte Uncoupling in Hyperhomocysteinemia. Archives of Physiology and Biochemistry 12(4):219-27, 2006.
  17. Allen Furr, Osborne Wiggins, Joseph C Banis Jr., Dalibor Vasilic, Michael Cunningham, Serge Martinez , Claudio Maldonado, Johannes M Frank, John H. Barker. A discussion of the psychosocial implications of disfigurement and the future of face transplantation. Plast Reconstruc Surg (2007) IN PRESS