John P. Wise, Sr., Ph.D.

Professor

Department of Pharmacology and Toxicology


CTRB 522 john.wise@louisville.edu 502–852–8524

Education

Ph.D., Pharmacology, The George Washington University (1994)

Research Areas and Projects

In my laboratory we seek to understand how environmental chemicals cause a normal cell to become a tumor cell. We study how these chemicals damage DNA and impact the DNA damage response. We consider how chemical-induced autophagy inhibition, loss of DNA repair and interference with mitosis cause centrosome amplification and chromosome instability as key outcomes in the carcinogenic process. We focus on humans, but we also work across wildlife species (e.g. whales, sea turtles, and alligators) considering toxicology in a “One” environmental health perspective. We also work on how cells respond differently in space. Students in my lab have both a laboratory component and a field research component to their projects.