Kyung Hong, Ph.D.

Assistant Professor of Medicine

Department of Medicine, Division of Cardiovascular Medicine


502-852-0686 kuhong01@louisville.edu

Research Interests:

Dr. Hong received his B.S. from University of California Davis and M.S. & Ph.D. from University of Rochester School of Medicine. He is currently interested in understanding the cardiac progenitor/stem cell biology and its application to clinical settings. He is experienced in diverse fields of biomedicine ranging from stem cell biology to molecular cancer biology. His previous research involved elucidating and characterizing the stem cells of the conducting airway epithelium using innovative transgenic and knockout mouse technology. During his postdoctoral training, he further extended his expertise to the fields of biochemistry and molecular biology by studying the mechanisms and functional importance of various post-translational modifications of novel tumor-associated proteins in the cell division process. He has recently joined the Cardiology research group at University of Louisville to become a part of the ongoing research effort focused on the cardiac stem cell biology.

Selected Publications:

Kim HJ, Kwon HR, Bae CD, Park J, Hong KU. Specific primary sequence requirements for Aurora B kinase-mediated phosphorylation and subcellular localization of TMAP during mitosis.Cell Cycle. 2010 May 15;9(10):2027-36. Epub 2010 May 15.

Hong KU, Kim HJ, Bae CD, Park J. Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein.Exp Mol Med. 2009 Nov 30;41(11):832-40.

Hong KU, Kim HJ, Kim HS, Seong YS, Hong KM, Bae CD, Park J. Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis.J Biol Chem. 2009 Jun 12;284(24):16501-12. Epub 2009 Apr 15.

Hong KU, Kim E, Bae CD, Park J. TMAP/CKAP2 is essential for proper chromosome segregation. Cell Cycle. 2009 Jan 15;8(2):314-24.

Hong KU, Choi YB, Lee JH, Kim HJ, Kwon HR, Seong YS, Kim HT, Park J, Bae CD, Hong KM. Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis.Exp Mol Med. 2008 Aug 31;40(4):377-86.

Hong KU, Park YS, Seong YS, Kang D, Bae CD, Park J. Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis.Mol Cell Biol. 2007 May;27(10):3667-81. Epub 2007 Mar 5.

Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium.Am J Pathol.2004 Feb;164(2):577-88.

Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations.Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L643-9. Epub 2003 Jul 18.

Hong KU, Reynolds SD, Giangreco A, Hurley CM, Stripp BR. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion.Am J Respir Cell Mol Biol.2001 Jun;24(6):671-81.

Reynolds SD, Hong KU, Giangreco A, Mango GW, Guron C, Morimoto Y, Stripp BR. Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells.Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1256-63.