Jonathan B. Chaires - Biophysical Characterization of the hTERT Promoter DNA Structure
| When |
Nov 30, 2018
from 03:00 PM to 04:00 PM |
|---|---|
| Where | Natural Science 102 |
| Contact Name | Swagato Banerjee, Ph.D. |
| Contact Phone | (502)-852-0915 |
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Speaker: Jonathan B. Chaires, James Graham Brown Cancer Center
Abstract: Telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase that is essential for the maintenance of telomeres, the protective end-capping structures of chromosomes. Expression of the gene that codes for hTERT is controlled by a promoter region that contains a sequence that potentially forms a four-stranded G-quadruplex structure, a novel DNA form distinct from the canonical and well-known duplex DNA first described by Watson and Crick. This seminar will describe our biophysical and biochemical studies aimed at defining the details of G-quadruplex structure. Supported by NIH grant GM 077422.