October 2024 Member Publications

  1. Rajagopalan S, McAlister S, Jay J, Pham RD, Brook RD, Nasir K, Nieuwenhuijsen MJ, Landrigan P, Wiesler A, Sanborn CV, Carron JR, Brooks KH, Bhatnagar A, Al-Kindi S. Environmental sustainability in cardiovascular practice: current challenges and future directions. Nat Rev Cardiol. 2024 Oct 25. doi: 10.1038/s41569-024-01077-z. Epub ahead of print. PMID: 39455886.
    Impact Statement: This publication highlights the critical need for environmental sustainability in cardiovascular care, aiming to reduce greenhouse gas emissions and pollution while potentially improving health outcomes and reducing healthcare costs. It outlines frameworks for sustainable practices, discusses carbon emissions and climate impacts of healthcare, and emphasizes prevention as a key strategy for minimizing the environmental footprint of cardiovascular care. 
  2. Yao Z, Tasdighi E, Dardari ZA, Erhabor J, Jha KK, Osuji N, Rajan T, Boakye E, Rodriguez CJ, Lima JAC, Judd S, Feldman T, Fialkow JA, Ramachandran VS, El Shahawy O, Benjamin EJ, Bhatnagar A, DeFilippis AP, Nasir K, Blaha MJ. Use of E-Cigarette, Traditional Cigarettes, and C-Reactive Protein: The Cross Cohort Collaboration. Am Heart J. 2024 Oct 24:S0002-8703(24)00275-8. doi: 10.1016/j.ahj.2024.10.012. Epub ahead of print. PMID: 39461654.
    Impact Statement: This cross-sectional study of 18,797 participants across six longitudinal cohorts found that exclusive electronic cigarette (EC) use was associated with significantly lower levels of high-sensitivity C-reactive protein (hs-CRP) compared to exclusive combustible cigarette use, suggesting a potentially reduced inflammatory response. However, hs-CRP levels in dual users and former smokers currently using ECs were similar to those of exclusive cigarette smokers, underscoring the importance of ongoing monitoring of EC use for tobacco regulation and public health. 
  3. He L, Xu R, Ma X, Yin X, Mueller E, Feng W, Menze M, Kim S, McClain CJ, Zhang X. Multiomics Studies on Metabolism Changes in Alcohol-Associated Liver Disease. J Proteome Res. 2024 Nov 1;23(11):4962-4972. doi: 10.1021/acs.jproteome.4c00451. Epub 2024 Oct 17. PMID: 39418671.
    Impact Statement: Quantification of polar metabolites and lipids in the liver of mice with experimental ALD shows that alcohol consumption drives metabolism toward lipid synthesis. Results from enzyme expression and activity detection indicated that the decreased activity of mitochondrial glycerol 3-phosphate dehydrogenase contributed to the disordered metabolism. 
  4. Zou W, Huang J. In reply: Fibreoptic or flexible bronchoscopy during bronchial blocker placement: time to stop perpetuating a bronchoscopic misnomer? Can J Anaesth. 2024 Oct 7. doi: 10.1007/s12630-024-02846-7. Epub ahead of print. PMID: 39375283.
    Impact Statement: This publication reply addresses the importance of using precise terminology, advocating for "flexible bronchoscope" instead of the misnomer "fibreoptic bronchoscope" in clinical settings. It also highlights the potential benefits of combining the loop-cinching and manual angulation techniques for improved bronchial blocker placement, calling for further study to validate these methods. 
  5. Adelmann D, Reddy M, Zhou GP, Fukazawa K, Wang R, Kassel C, Nguyen-Buckley C, Bastidas J, De Marchi L, Wilson EA, Nazemian R, Fernandez-Bustamante A, Anderson A, Chadha RM, Huang J, Moguilevitch M, Townsend E, Rosenfeld DM, Kothari RP. The perioperative care in liver transplantation multicenter database: Building the foundation for research collaboration in liver transplantation. J Clin Anesth. 2024 Oct 21;99:111651. doi: 10.1016/j.jclinane.2024.111651. Epub ahead of print. PMID: 39437663.
    Impact Statement: The Society for the Advancement of Transplant Anesthesia (SATA) Perioperative Care in Liver Transplantation Multicenter Database (SATA liver database) is a groundbreaking initiative that enables standardized, multicenter data collection for perioperative liver transplant care, currently engaging 17 U.S. transplant centers. By fostering data collaboration and facilitating comprehensive research, the SATA liver database is positioned to significantly advance patient outcomes and enhance clinical insights in liver transplantation. 
  6. Polivka B, Krueger K, Bimbi O, Huntington-Moskos L, Nyenhuis S, Cramer E, Eldeirawi K. Integrating Real-Time Air Quality Monitoring, Ecological Momentary Assessment, and Spirometry to Evaluate Asthma Symptoms: Usability Study. JMIR Form Res. 2024 Oct 10;8:e60147. doi: 10.2196/60147. PMID: 39388233; PMCID: PMC11502973.
    Impact Statement: This study demonstrates that integrating indoor air quality monitoring, ecological momentary assessment, and home spirometry is both acceptable and usable for adults with asthma, offering valuable insights into real-time environmental exposures and asthma outcomes. Participant feedback highlighted technical challenges and usability improvements that can enhance future research in this area. 
  7. Alejandro B, Kim EJ, Hwang JY, Park JW, Smith M , Chung D. Genetic and phenotypic changes to Venezuelan equine encephalitis virus following treatment with β-D-N4-hydroxycytidine, an RNA mutagen. Sci Rep. 2024 Oct 25;14(1):25265. doi: 10.1038/s41598-024-76788-x. PMID: 39448734; PMCID: PMC11502654.
    Impact Statement: This study provides a detailed understanding on how viruses adapt to new environments and how RNA mutagens can affect the viral population landscape. It's a big step toward developing more effective antiviral treatment. 
  8. Lakshmanan J, Jaganathan VL, Zhang B, Werner G, Allen TS, Schultz DJ, Klinge CM , Harbrecht BG. Anticancer Properties Against Select Cancer Cell Lines and Metabolomics Analysis of Tender Coconut Water. Anticancer Agents Med Chem. 2024 Oct 15. doi: 10.2174/0118715206327789241008162423. Epub ahead of print. PMID: 39411967.
    Impact Statement: Tender coconut water (TCW) stimulates the viability of primary rat hepatocytes but inhibits the viability of breast, liver, and colon cancer cells in vitro. Untargeted metabolomics was used to identify the TCW metabolites with anti-cancer activity. TCW contains 271 metabolites, primarily lipids and lipid-like molecules, phenylpropanoids and polyketides, and organic oxygen compounds. We reported that three components from TCW: 3-hydroxy-1-(4-hydroxyphenyl)propan-1-one, iondole-3-carbox aldehyde and caffeic acid that inhibited the growth of cancer cells and altered the transcript and protein abundance of genes involved in epithelial-to-mesenchymal transition and pathways in intracellular kinase signaling. 
  9. Vielee ST, Buchanan WJ, Roof SH, Kahloon R, Evans E, Isibor J, Patel M, Meaza I, Lu H, Williams AR, Kouokam JC, Wise SS, Guo L, Wise RM, Wise JL, Cai L, Cai J, Wise JP Jr. Chromium Selectively Accumulates in the Rat Hippocampus after 90 Days of Exposure to Cr(VI) in Drinking Water and Induces Age- and Sex-Dependent Metal Dyshomeostasis. Toxics. 2024 Oct 3;12(10):722. doi: 10.3390/toxics12100722. PMID: 39453142; PMCID: PMC11510846.
    Impact Statement: This study reveals that hexavalent chromium [Cr(VI)], a metal commonly polluting drinking water, selectively accumulated in the hippocampus of rats following a 90-day drinking water exposure at levels currently deemed safe. Our study considered both sexes and three age groups; though the most drastic accumulation of chromium was observed in the hippocampus of geriatric females, we further observed Cr(VI) disrupted essential metal homeostasis across all ages and both sexes. These findings highlight age- and sex-specific vulnerabilities to Cr(VI) exposure and underscore the need for further toxicological investigation into its broader impacts on brain health. 
  10. Hardesty JE, McClain CJ. Current Pharmacotherapy and Nutrition Therapy of Alcohol-Associated Liver Disease. Clin Liver Dis. 2024 Nov;28(4):731-745. doi: 10.1016/j.cld.2024.06.018. Epub 2024 Aug 13. PMID: 39362718; PMCID: PMC11529778.
    Impact Statement: Patients with alcohol-associated liver disease (ALD) consume large amounts of empty calories and are at risk for malnutrition. Malnutrition can present with micro- or macro-nutrient deficiencies. The standard-of-care drug treatment for severe alcohol-associated hepatitis (AH) is corticosteroids. While still in the standard treatment there are limitations in efficacy and certain patients do not respond to treatment (Lille score ≥.45). This article will focus on important concepts related to nutrition and ALD and on recent findings on predicting corticosteroid response and prognosis for AH patients. 
  11. Brown K, Funk K, Figueroa Barrientos A, Bailey A, Shrader S, Feng W, McClain CJ, Song ZH. The Modulatory Effects and Therapeutic Potential of Cannabidiol in the Gut. Cells. 2024 Sep 26;13(19):1618. doi: 10.3390/cells13191618. PMID: 39404382; PMCID: PMC11475737.
    Impact Statement: This review highlights the therapeutic potential of cannabidiol (CBD) in modulating gastrointestinal health, including its effects on intestinal permeability, the microbiome, and immune responses. Evidence suggests that CBD’s impact on the GI system may also benefit conditions beyond the gut, such as liver disease and multiple sclerosis, pointing to its broader therapeutic value. 
  12. Kumar K, Bosch K, Vemuri V, Kratholm N, Rane M, Kakar SS. Withaferin A ameliorates ovarian cancer-induced renal damage through the regulation of expression of inflammatory cytokines. J Ovarian Res. 2024 Oct 11;17(1):199. doi: 10.1186/s13048-024-01519-9. PMID: 39394174; PMCID: PMC11468018.
    Impact Statement: This study demonstrates that peritoneal ovarian cancer in NSG mice induces kidney damage and renal dysfunction, characterized by elevated inflammatory cytokines and plasma creatinine levels. Treatment with withaferin A (WFA) significantly mitigated these effects, highlighting its potential as a therapeutic agent to counteract ovarian cancer-induced kidney injury. 
  13. Tomlinson MM, Kerstiens S, Smith C, Agbonlahor O, Clarke J, Vincent K, Walker KL, McLeish AC, Keith RJ, Smith T, Yeager RA, Wood LA, , Bhatnagar A,Hart JL. The association between perceived neighborhood safety and cardiovascular disease risk factors. Psychol Health Med. 2024 Oct 3:1-12. doi: 10.1080/13548506.2024.2410418. Epub ahead of print. PMID: 39360605.
    Impact Statement: This study reveals a significant association between low perceived neighborhood safety and increased cardiovascular disease risk factors, with males particularly vulnerable to this link. The findings highlight the importance of addressing environmental safety to mitigate CVD risk, especially in men. 
  14. Holm RH, Smith T. Does Wastewater-Based Surveillance Protect the Health of Incarcerated Individuals? Am J Public Health. 2024 Nov;114(11):1156-1157. doi: 10.2105/AJPH.2024.307857. PMID: 39356993; PMCID: PMC11447773.
    Impact Statement: We discuss how wastewater-based surveillance (WBS) in carceral facilities can provide early detection of infectious diseases, guiding efficient resource allocation and reducing the need for widespread clinical testing. This approach not only enhances health protections for incarcerated populations but also supports broader public health by offering a proactive tool for disease monitoring and tactical public health interventions to prevent disease spread. 
  15. Ritzenthaler JD, Watson WH, Roman J. α4 Nicotinic Acetylcholine Receptors in Lipopolysaccharide-Related Lung Inflammation. Int J Mol Sci. 2024 Oct 21;25(20):11305. doi: 10.3390/ijms252011305. PMID: 39457087; PMCID: PMC11509036.
    Impact Statement: This study identifies a novel mechanism of acute lung injury in sepsis, demonstrating that lipopolysaccharide (LPS) activates α4 nicotinic acetylcholine receptors (α4 nAChRs) in immune cells, driving oxidative stress and proinflammatory gene expression. Targeting α4 nAChRs with specific inhibitors, such as DHβE, mitigates these effects, offering potential therapeutic insights for improving sepsis outcomes. 
  16. Saedi S, Tan Y, Watson SE, Wintergerst KA, Cai L. Potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes. Front Endocrinol (Lausanne). 2024 Oct 2;15:1461171. doi: 10.3389/fendo.2024.1461171. PMID: 39415790; PMCID: PMC11479913.
    Impact Statement:Diabetes and its complications are major diseases that affect human health, however, whether if the individuals with diabetes are also exposed to environmental metals, there will be high risk for these population lack a clear answer. Therefore, this review has focused on collecting the available evidence to specifically discuss whether two kinds of metal-mediated cell death, ferroptosis, an iron-dependent cell death, and cuproptosis, a copper-dependent cell death, as main mechanistic pathogenesis play certain roles in the acceleration of diabetes and diabetic complications. In the end, we demonstrated the limited information that suggests the potential links, however, more direct evidence remains needed. This review also provides perspectives on the investigation for potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes. 
  17. Meaza I, Williams AR, Wise SS, Lu H, Pierce JW Sr. Carcinogenic Mechanisms of Hexavalent Chromium: From DNA Breaks to Chromosome Instability and Neoplastic Transformation. Curr Environ Health Rep. 2024 Oct 28. doi: 10.1007/s40572-024-00460-9. Epub ahead of print. PMID: 39466546.
    Impact Statement: Hexavalent chromium [Cr(VI)] exposure induces DNA double-strand breaks, repair deficiencies, and chromosome instability, which are central to its carcinogenic mechanism and neoplastic transformation in cells, animals, and humans. This review highlights recent evidence of Cr(VI)'s genotoxic effects, including structural and numerical chromosome instability, emphasizing its role in lung cancer development and broader ecological impacts on wildlife. 
  18. Chaudhari M, Zelko I, Lorkiewicz P, Hoetker D, Nong Y, Doelling B, Brittian K, Bhatnagar A, Srivastava S, Baba SP. Metabolic pathways for removing reactive aldehydes are diminished in the skeletal muscle during heart failure. Skelet Muscle. 2024 Oct 18;14(1):24. doi: 10.1186/s13395-024-00354-2. PMID: 39425168; PMCID: PMC11488087.
    Impact Statement:This study highlights the role of oxidative stress-induced aldehyde accumulation and reduced detoxifying capacity in heart failure-related muscle wasting. Findings suggest that decreased histidyl dipeptide levels and aldehyde-removing enzymes in skeletal muscle contribute to increased atrophy and inflammation, potentially exacerbating functional decline in heart failure patients.