Carolyn M. Klinge, Ph.D., Cycle 8 - October 2022 OEFC Awardee
Medium OEFC Research Voucher Award(s): Medium research voucher applications support the expenses (up to $5,000) associated with critical exploratory research and proof-of-concept studies needed by CIEHS members for hypothesis generation and grant (re-) submission.
Principal Investigator: Carolyn Klinge, Ph.D.
Collaborator: Michael Merchant, Ph.D.
Title: Selenoprotein Analysis in a Murine Model of PCB-Induced TASH
Lay Description: Exposure to environmental pollutants including polychlorinated biphenyls (PCBs) are associated with progression of nonalcoholic fatty liver disease (NAFLD). We identified changes in a chemical modifications of RNA associated with translation of selenoproteins that protect the liver from injury in a mouse model of NAFLD after PCB exposure. The major goal of this study is to determine if PCBs alter selenoprotein levels in a mouse model of environmental exposure-associated NAFLD.