2023 SOT Awards and Announcements — Center for Integrative Environmental Health Sciences

Congratulations to CIEHS members who served as chairs, won awards, and presented at the Society of Toxicology (SOT) annual meeting that occurred March 19-23 (Members names in bold).

Awards

Best Postdoctoral Publication Award
Alexandra Nail, Ph.D. (States lab)
Nail AN, McCaffrey LM, Banerjee M, Ferragut Cardoso AP, States JC. Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes. Toxicol Appl Pharmacol. 2022 Jul 1;446:116042. doi: 10.1016/j.taap.2022.116042. Epub 2022 May 2. PMID: 35513056; PMCID: PMC9318262.

Best Paper of the Year Award from the Dermal Toxicology Specialty Section
Ana P. Ferragut Cardoso, Ph.D. (States lab) and Mayukh Banerjee, Ph.D.
Ferragut Cardoso AP, Banerjee M, Al-Eryani L, Sayed M, Wilkey DW, Merchant ML, Park JW, States JC. Temporal Modulation of Differential Alternative Splicing in HaCaT Human Keratinocyte Cell Line Chronically Exposed to Arsenic for up to 28 Wk. Environ Health Perspect. 2022 Jan;130(1):17011. doi: 10.1289/EHP9676. Epub 2022 Jan 24. PMID: 35072517; PMCID: PMC8785870.

Exposure Specialty Section Best Paper Award
Pawel Lorkiewicz, Ph.D. and Daniel J Conklin, Ph.D.
Lorkiewicz P, Keith R, Lynch J, Jin L, Theis W, Krivokhizhina T, Riggs D, Bhatnagar A, Srivastava S, Conklin DJ. Electronic Cigarette Solvents, JUUL E-Liquids, and Biomarkers of Exposure: In Vivo Evidence for Acrolein and Glycidol in E-Cig-Derived Aerosols. Chem Res Toxicol. 2022 Feb 21;35(2):283-292. doi: 10.1021/acs.chemrestox.1c00328. Epub 2022 Jan 19. PMID: 35044764; PMCID: PMC8864610.

Celebrating Women in Toxicology Award Fund
Jamie Young, Ph.D.

Environmental Carcinogenesis Research Fellowship Fund
Jennifer Toyoda, MSc (Wise lab)

Bruce A. Fowler Metals Endowment Fund
John Wise, Jr., Ph.D.

Bruce A. Fowler Young Investigator Award
Jamie Young, Ph.D.

Vice President-elect for Metals Specialty Section
Jamie Young, Ph.D.

Cardiovascular Toxicity Specialty Section Impact award
Lu Cai, MD, Ph.D.
Wang X, Chen X, Zhou W, Men H, Bao T, Sun Y, Wang Q, Tan Y, Keller BB, Tong Q, Zheng Y, Cai L. Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways. Acta Pharm Sin B. 2022 Feb;12(2):708-722. doi: 10.1016/j.apsb.2021.10.005. Epub 2021 Oct 15. PMID: 35256941; PMCID: PMC8897044.

Metals Specialty Section Student Research Award Fund
Ana Ferragut Cardoso, Ph.D. (States lab)
Aggie Williams, BA (Wise lab)
Idoia Meaza Isusi, MS (Wise Lab)

Dharm V. Singh Carcinogenesis Award Fund
Idoia Meaza Isusi (Wise Lab)
Haiyan Lu (Wise Lab)

Served as Chair or Co-Chair

Chair: Petra Haberzettl, Ph.D., Air Pollution Toxicology III
Chair: Lu Cai, MD, Ph.D., Metals Matter: The Potential Effects of Metal-Mediated Cell Death in the Pathogenesis of Cardiopulmonary Diseases
Chair: Idoia Meaza Isusi (Wise Lab), Metals II
Co-Chair: S anjay Srivastava, Ph.D., Workshop Session-The Disheartening Role of Volatile Organic Compounds in Cardiopulmonary Disease. Main Session: A Current Perspective on Environmental Chemicals and Their Role in Initiating and Exacerbating Cardiovascular Disease

Poster Sessions

Impact of Long-Term Aroclor 1260 Exposure on Gut Microbiome and Intestinal Toxicity. N. V. Adiele, R. Singhal, K. Z. Head, B. J. Petri, K. M. Piell, J. Luo, T. C. Gripshover, E. C. Rouchka, M. C. Cave, C. M. Klinge, and B. Wahlang.

Chronic Arsenic Exposure Inhibits Both Autophagy and Proteasomal Protein Degradation in Human Keratinocytes. I. Augenstein, M. Banerjee, A. N. Nail, A. P. Ferragut Cardoso, and J. Christopher States

Zinc Supplementation Prevents Mitotic Accumulation in Human Keratinocyte Cell Lines upon Environmentally Relevant Arsenic Exposure. M. Banerjee, K. Yaddanapudi, and J. C. States.

Subchronic Dietary Zinc Supplementation in a Diet-Induced Obesity Model: Implication for Toxicant-Associated Fatty Liver Disease. O. Bolatimi, J. L. Young, B. Wahlang, J. Luo, K. Z. Head, T. C. Gripshover, Q. Li, C. White, N. White, W. H. Watson, C. Wilkerson, L. Cai, and M. C. Cave.

Diverse Effects of Early-Life Cadmium and Post-Weaning High-Fat Diet Exposures on Neuropathology and Behavioral Impairment in Offspring Mice. W. Zeng, T. Chu, J. P. Wise Jr, L. Cai, G. Barnes, and J. Cai

Cooling Agents Exacerbate E-cigarette-Induced Cardiac Arrhythmias and Sympathetic Dominance in Mice. C. Kucera, A. Ramalingam, A. Bhatnagar, and A. P. Carll

Effects of Cadmium on Pulmonary Arterial Hypertension. D. D. Cathey, J. Huang, L. Cai, Y. Tan, and J. Cai. Per- and Polyfluoroalkyl Substance (PFAS) Exposures Are Associated with Liver Steatosis and Fibrosis in Adult NHANES 2017-2018. N. Samala, S. Yogesh, R. Lele, T. C. Gripshover, B. Wahlang, L. Jophlin, B. McGrath, J. Young, N. Chalasani1, S. Rai, and M. Cave

Ethanol Exposure Disrupted the Formation of Radial Glial Processes and Impaired the Generation, Migration, and Transformation of Outer Radial Glia Cells in Human Forebrain Organoids. L. Lu, J. Liu, and S. Chen

The Intracellular Cholesterol Transporter STARD5 Contributes to Endoplasmic Reticulum Stress-Induced Changes in Liver Lipid Metabolism. B. J. Clark, V. Patel, S. Travers, K. M. Piell, S. N. Rai, J. Pan, K. M. De Silva, E. C. Rouchka, and C. M. Klinge

Polychlorinated Biphenyl 126 Alters the Hepatic Transcriptome to Enhance Alcohol-Associated Liver Disease. T. C. Gripshover, B. Wahlang, K. Z. Head, E. Rouchka, J. L. Young, J. Luo, I. A. Kirpich, and M. C. Cave

Fine Particulate Matter (PM2.5) Increases Metabolic Injury in Light-Induced Circadian Dyssynchrony (LICD) by Inducing Pulmonary Oxidative Stress. P. Haberzettl, A. Ribble, D. Conklin, and A. Bhatnagar.

The Role of Human N-Acetyltransferase 1 Genetic Polymorphism in Metabolism and Genotoxicity Induced by Benzidine in Chinese Hamster Ovary Cells. M. R. Habil, M. A. Doll, and D. W. Hein

Female Mice Are Protected against Fine Particulate Matter-Induced Glucose Intolerance in Circadian Dyssynchrony but Not Cardiovascular Insulin Resistance, M. Kitching, A. Ribble, and P. Haberzettl

Disruption of the Mouse Liver Epitranscriptome by Aroclor 1260 Exposure and Diet. C. M. Klinge, K. M. Piell, B. J. Petri, K. Z. Head, B. Wahlang, L. He, X. Zhang, J. Pan, S. N. Rai, K. M. DeSilva, J. H. Chariker, E. C. Rouchka, M. Tan, Y. Li, and M. C. Cave

Particulate Hexavalent Chromium Increases Reactive Oxygen Species Production and Regulates Multiple Inflammatory Pathways in Human Lung Fibroblasts. J. Kouokam, R. M. Speer, I. Meaza, J. Toyoda, H. Lu, and J. Wise

Translating Particulate Hexavalent Chromium-Induced DNA Damage and DNA Repair Impacts from Human Lung Cells to Lung Tissue. H. Lu, S. S. Wise, G. Hoyle, J. H. Toyoda, R. M. Speer, T. J. Croom-Perez, I. Meaza, A. Williams, J. P. Wise Jr., J. Kouokam, J. L. Young,L. Cai, C. Zhu, K. Kondo, T. Zheng, L. T. Haber, and J. P. Wise Sr.

The Effects of Fluorene Exposure in Conjunction with High-Fat Diet on Toxicant-Associated Fatty Liver Disease. J. Luo, B. Wahlang, W. H. Watson, C. M. White, S. Singh, O. E. Bolatimi, N. V. Adiele, L. L. Jophlin, J. L. Marshall, R. J. Sullivan, and M. C. Cave

Sex-Dependent Effects of Vinyl Chloride, a Chemical Carcinogen, on the Hepatic Transcriptome Impact Carcinogenic Endpoints. B. Luulay, R. Singhal, E. C. Rouchka, J. I. Beier, M. C. Cave, S. Srivastava, and B. Wahlang

Association of Ambient Volatile Organic Compounds with Circulating Endothelial Cell-Derived Microparticles. M. V. Malovichko, S. Srivastava, S. McFall, B. S. Taylor, R. J. Keith, D. W. Riggs, A. Bhatnagar, and S. Srivastava

Hexavalent Chromium-Induced Cohesin Malfunction Drives Chromosome Instability, a Key Step in the Mechanism of Carcinogenesis. I. Meaza, J. H. Toyoda, C. Cahill, C. J. Kouokam, and J. P. Wise Sr

Chronic Arsenic Exposure Reduces ATM Pathway Activation in Human Keratinocytes. A. N. Nail, L. Montero, A. P. Ferragut Cardoso, M. Banerjee, and J. States

Mentholated Fourth-Generation E-cig Aerosols Induce Ventricular Arrhythmias and Early Repolarization Defects in Mice. R. Paily, C. Kucera, A. Ramalingam, P. K. Lorkiewicz, S. Srivastava, A. Bhatnagar, and A. P. Carll

Polychlorinated Biphenyls Dysregulate Hepatic Alternative Splicing Machinery by Altering Expression of Splicing Factors in a Mouse Model of Environmental Liver Disease. B. J. Petri, K. M. Piell, B. Wahlang, E. C. Rouchka, J. W. Park, J. Jin, J. E. Hardesty, M. C. Cave, and C. M. Klinge

Organic Acids Influence E-cigarette-Induced Cardiac Conduction Defects and Autonomic Imbalance. A. R. Ramalingam, A. Bhatnagar, and A. Carll

Impact of miR-186 Overexpression on Arsenite Exposure-Induced Gene Expression and Transformation. M. Banerjee, A. P. Ferragut Cardoso, A. Lykoudi, J. W. Park, and J. C. States

A Toxic Aging Coin: An Assessment of Cr(VI)-Induced Biological Aging in the Brain. S. T. Vielee, A. R. Williams, H. Lu, I. I. Meaza, J. H. Toyoda, J. P. Wise Sr., and J. P. Wise Jr

Sex Differences in the Hepatic Proteome and Gut Microbiome following Polychlorinated Biphenyl Exposures: Implications on Gut-Liver Axis Disruption in Females. B. Wahlang, Z. Qaissi, R. Singhal, E. C. Rouchka, M. C. Cave, J. Pan, M. L. Merchant, and S. N. Rai

Relative Sensitivity to Acute Arsenic Toxicity among Different Keratinocyte Cell Lines Is Determined by Differences in Glutathione Production. W. H. Watson, C. Wilkerson, M. Banerjee, A. R. Pinhas, J. States, and A. Ferragut Cardoso

Alcohol Dysregulates Sirt1-Mediated Metabolic Signaling Pathways through Alpha-4 Nicotinic Acetylcholine Receptors in Hepatocytes. C. Wilkerson, J. Luo, and W. H. Watson

Stable Isotope Tracing of Glucose in N-Acetyltransferase 1 (NAT1) Knockout Breast Cancer Cells Reveals NAT1 Plays a Role in the Proper Functioning of Mitochondria. J. T. Wise, X. Yin, M. A. Doll, X. Zhang, and D. W. Hein

Investigating the Environmental Risk Factors of Diabetes Epidemic with a Focus on Heavy Metal Exposure. C. H. Zhang, M. Kong, B. Guinn, and L. Cai

MMP-3-Mediated Cleavage of OPN Is Involved in Copper Oxide Nanoparticle-Induced Activation of Fibroblasts. Y. Zhang, Y. Mo, J. Yuan, and Q. Zhang

Delphinidin Alleviates the Adverse Metabolic Effects of Polystyrene Exposure in Mice. J. Zhao, D. Gomes, A. NgozI, D. Conklin,M. Cave, and T. O'Toole

Symposium Session
Using a Toxic Aging Coin to Investigate the Intersection of Toxicology and Aging: Heads for Age Differences, Tails for Gerontogens. John Wise Jr., Ph.D.

Hexavalent Chromium-Induced DNA Damage Contributes to Brain Aging. John Wise Jr., Ph.D.

Featured Session
Hexavalent Chromium [Cr(VI)] Targets Rad51 to Drive Carcinogenesis in Lung Cancer. John Wise Sr., Ph.D.

Platform Session
Electronic Cigarette-Derived Aerosols, Formaldehyde, and the Transient Receptor Potential Ankyrin 1 in Endothelial Dysfunction in Mice. L. Jin, L. Fryar, and D. J. Conklin.

SOT TV finds out more from Dr. John Wise, Jr. about why the intersection of toxicology and aging is going to be so relevant in the future, watch video below.