June 2023 Member Publications
- Erhabor J, Boakye E, Osuji N, Obisesan O, Osei AD, Mirbolouk H, Stokes AC, Dzaye O, El-Shahawy O, Rodriguez CJ, Hirsch GA, Benjamin EJ, DeFilippis AP, Robertson RM, Bhatnagar A, Blaha MJ. Psychosocial stressors and current e-cigarette use in the youth risk behavior survey. BMC Public Health. 2023 Jun 6;23(1):1080. doi: 10.1186/s12889-023-16031-w. PMID: 37280552; PMCID: PMC10242777.
Impact Statement: The study demonstrates a significant association between psychosocial stressors and adolescent e-cigarette use, highlighting the potential importance of interventions, such as targeted school-based programs that address stressors and promote stress management, as possible means of reducing adolescent e-cigarette use. Future research directions include exploring underlying mechanisms linking stressors to e-cigarette use and evaluating the effectiveness of interventions addressing stressors in reducing adolescent e-cigarette use.
- April-Sanders AK, Daviglus ML, Lee UJ, Perreira KM, Kaplan RC, Blaha MJ, Pirzada A, Giachello AL, Bhatnagar A, Robertson RM, Thanh-Huyen TV, Rodriguez CJ. Prevalence of electronic cigarette use and its determinants in us persons of Hispanic/Latino background: The Hispanic community health study / study of Latinos (HCHS/SOL). Am J Med Open. 2023 Jun;9:100029. doi: 10.1016/j.ajmo.2022.100029. Epub 2022 Nov 24. PMID: 37388413; PMCID: PMC10310062.
Impact Statement: This study found that Hispanic/Latino individuals who are young adults, male, US-born, and have high acculturation were more likely to report current electronic nicotine delivery systems (ENDS) use. These findings could inform preventive and regulatory interventions targeted to Hispanics/Latinos.
- Boakye E, Uddin SMI, Osuji N, Meinert J, Obisesan OH, Mirbolouk M, Tasdighi E, El-Shahawy O, Erhabor J, Osei AD, Rajan T, Patatanian M, Holbrook JT, Bhatnagar A, Biswal SS, Blaha MJ. Examining the association of habitual e-cigarette use with inflammation and endothelial dysfunction in young adults: The VAPORS-Endothelial function study. Tob Induc Dis. 2023 Jun 10;21:75. doi: 10.18332/tid/162327. PMID: 37305426; PMCID: PMC10257221.
Impact Statement: The publication suggest that e-cigarette use may not be significantly associated with endothelial dysfunction and systemic inflammation in relatively young and healthy individuals. Longer term studies with larger sample sizes are needed to validate these findings.
Cai L. Impact of Nutrition or FDA-Approved Medicine Repurposing on Metabolic Syndrome and Diabetic Complications. Nutrients. 2023 May 29;15(11):2515. doi: 10.3390/nu15112515. PMID: 37299478; PMCID: PMC10255908.
Impact Statement: This publication includes research on obesity and diabetes, focusing on their underlying causes and potential interventions using nutrients and natural products. The findings emphasize the importance of studying these conditions to develop effective strategies for managing and preventing their complications.
- Nault R, Cave MC, Ludewig G, Moseley HNB, Pennell KG, Zacharewski T. A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data. Environ Health Perspect. 2023 Jun;131(6):65001. doi: 10.1289/EHP11484. Epub 2023 Jun 23. PMID: 37352010; PMCID: PMC10289218.
Impact Statement: This manuscript reveals ways to optimize the reuse of environmental health science data using the FAIR principles. The content was developed by several collaborating Superfund Research Centers (also including Michigan State, UK and Iowa) with the support of a data science supplement from NIEHS/Superfund.
- Hong KU, Hein DW. N-acetyltransferase 2 haplotype modifies risks for both dyslipidemia and urinary bladder cancer. Pharmacogenet Genomics. 2023 May 29. doi: 10.1097/FPC.0000000000000500. Epub ahead of print. PMID: 37306342.
Impact Statement: A novel haplotype in N-acetyltransferase 2 (NAT2) comprised of seven, non-coding variants (rs1495741, rs4921913, rs4921914, rs4921915, rs146812806, rs35246381, rs35570672) has been linked to both dyslipidemia and urinary bladder cancer by multiple, independent genome wide association studies. We speculate that rs1495741 (and its associated haplotype) belongs to a distal regulatory element of human NAT2 gene (e.g., enhancer or silencer), and the genetic variation at the newly discovered haplotype results in a differential level of NAT2 gene expression. Understanding how this NAT2 haplotype contributes to urinary bladder cancer and dyslipidemia will ultimately help devise strategies to identify and protect susceptible individuals.
- Jin L, Liang Y, Yu Y, Miao P, Huang Y, Xu L, Wang H, Wang C, Huang J, Guo K. Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study. Drug Des Devel Ther. 2023 Jun 7;17:1665-1677. doi: 10.2147/DDDT.S406929. PMID: 37309414; PMCID: PMC10257907.
Impact Statement: Multimodal regimen by paracetamol, gabapentin, ketamine, lidocaine, dexmedetomidine and sufentanil among cardiac surgery patients, reduced perioperative opioid consumption along with rescue analgesia rate with similar length of stay and the incidences of postoperative complications.
- Ander M, Mugve N, Crouch C, Kassel C, Fukazawa K, Izaak R, Deshpande R, McLendon C, Huang J. Regional anesthesia for transplantation surgery - A white paper part 1: Thoracic transplantation surgery. Clin Transplant. 2023 Jun 12:e15043. doi: 10.1111/ctr.15043. Epub ahead of print. PMID: 37306898.
Impact Statement: Society for the Advancement of Transplant Anesthesia (SATA) identified experts in both transplantation surgery and regional anesthesia to review available literature concerning these topics. The goal of this task force was to provide an overview of these publications to help guide transplantation anesthesiologists in utilizing regional anesthesia.
- Hartson KR, Huntington-Moskos L, Sears CG, Genova G, Mathis C, Ford W, Rhodes RE. Use of Electronic Ecological Momentary Assessment Methodologies in Physical Activity, Sedentary Behavior, and Sleep Research in Young Adults: Systematic Review. J Med Internet Res. 2023 Jun 29;25:e46783. doi: 10.2196/46783. PMID: 37384367.
Impact Statement: This publication showcases how advanced technology allows researchers to study physical activity, sedentary behavior, and sleep in young adults through real-time data collection. The study highlights the growing use of electronic ecological momentary assessment (eEMA) but also identifies the need for standardized reporting and inclusion of diverse populations to improve research in this area.
- Vatsalya V, Royer AJ, Jha SK, Parthasarathy R, Tiwari H, Feng W, Ramchandani VA, Kirpich IA, McClain CJ. Drinking and laboratory biomarkers, and nutritional status characterize the clinical presentation of early-stage alcohol-associated liver disease. Adv Clin Chem. 2023;114:83-108. doi: 10.1016/bs.acc.2023.02.001. Epub 2023 May 5. PMID: 37268335.
Impact Statement: This publication thoroughly investigates the early-stage of alcohol-associated liver disease (ALD) caused by chronic and heavy alcohol consumption, shedding light on the complex interactions between different pathways, including nutritional changes. It provides valuable insights into identifying and understanding this condition through clinical markers and laboratory measures.
- Bhayana S, Zhao Y, Merchant M, Cummins T, Dougherty JA, Kamigaki Y, Pathmasiri W, McRitchie S, Mariani LH, Sumner S, Klein JB, Li L, Smoyer WE; Pediatric Nephrology Research Consortium. Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a "Patient-Specific" Approach. Kidney Int Rep. 2023 Mar 23;8(6):1239-1254. doi: 10.1016/j.ekir.2023.03.015. PMID: 37284673; PMCID: PMC10239920.
Impact Statement: Nephrotic syndrome (NS) occurs commonly in children with glomerular disease, resistance to the mainstay treatment, glucocorticoids (GCs), develops in 15% to 20% of children, increasing the risk of chronic kidney disease compared to steroid sensitive NS (SSNS). We employed a novel "patient-specific" bioinformatic approach to merge paired pre-GC- and post-GC-treatment proteomic and metabolomic data and identify candidate SRNS biomarkers and altered molecular pathways in SRNS versus SSNS. Joint pathway analyses revealed perturbations in nicotinate or nicotinamide and butanoate metabolic pathways in patients with SRNS. Patients with SSNS had perturbations of lysine degradation, mucin type O-glycan biosynthesis, and glycolysis or gluconeogenesis pathways. These studies confirmed that a novel "patient-specific" bioinformatic approach can integrate disparate omics datasets and discover candidate SRNS biomarkers not observed by separate proteomic or metabolomic analysis.
- Li J, Sato T, Hernández-Tejero M, Beier JI, Sayed K, Benos PV, Wilkey DW, Humar A, Merchant ML, Duarte-Rojo A, Arteel GE. The plasma degradome reflects later development of NASH fibrosis after liver transplant. Sci Rep. 2023 Jun 20;13(1):9965. doi: 10.1038/s41598-023-36867-x. PMID: 37340062; PMCID: PMC10282030.
Impact Statement: Liver transplantation (LT) is an effective therapy for cirrhosis but the incidence of post-LT NASH reoccurance, accelerated progression to fibrosis/cirrhosis, and decreased survival is alarmingly high. The inflammation induced hepatic ECM remodeling has been demonstrated to alter the circulating ECM and parenchymal peptide fragments (i.e., 'degradome') in plasma, making it a useful diagnostic/prognostic tool in chronic liver disease. Proteomic methods and supervised modeling of the degradome data was used to investigate whether liver injury caused by post-LT NASH would yield a unique degradome profile that is predictive of severe post-LT NASH fibrosis. A retrospective analysis of 22 biobanked samples from the Starzl Transplantation Institute (12 with post-LT NASH after 5 years and 10 without) was conducted on ~ 2700 identifiable peptide features. The ECM degradome was significantly altered in patients that later developed fibrosis and heatmap analysis clustered the 2 patient groups well. A similar degradome profile was observed when the plasma degradome patterns were compared being obesity sensitive (C57Bl6/J) and insensitive (AJ) mouse strains. The plasma degradome profile of post-LT patients yielded stark difference based on later development of post-LT NASH fibrosis. This approach could yield new "fingerprints" that can serve as minimally-invasive biomarkers of negative outcomes post-LT.
- Benner SE, Zhu X, Hussain S, Florman S, Eby Y, Fernandez RE, Ostrander D, Rana M, Ottmann S, Hand J, Price JC, Pereira MR, Wojciechowski D, Simkins J, Stosor V, Mehta SA, Aslam S, Malinis M, Haidar G, Massie A, Smith ML, Odim J, Morsheimer M, Quinn TC, Laird GM, Siliciano R, Balagopal A, Segev DL, Durand CM, Redd AD, Tobian AAR. HIV-positive liver transplant does not alter the latent viral reservoir in recipients with ART-suppressed HIV. J Infect Dis. 2023 Jun 28:jiad241. doi: 10.1093/infdis/jiad241. Epub ahead of print. PMID: 37379584.
Impact Statement: This study investigated whether receiving a liver transplant from an HIV-positive donor affects the viral reservoir in HIV-positive recipients. The results showed that the viral reservoir remained stable after liver transplantation, regardless of whether the donor was HIV-positive or HIV-negative.
- Holm RH, Pocock G, Severson MA, Huber VC, Smith T, McFadden LM. Using wastewater to overcome health disparities among rural residents. Geoforum. 2023 Aug;144:103816. doi: 10.1016/j.geoforum.2023.103816. Epub 2023 Jun 26. PMID: 37396346; PMCID: PMC10292026.
Impact Statement: This commentary addresses the disparities in rural health during the SARS-CoV-2 pandemic and proposes the use of wastewater surveillance as an innovative tool to address these disparities. By reviewing successful implementations in South Africa, we conclude that wastewater surveillance can help monitor diseases in underserved areas, improve disease detection among rural residents, and potentially identify future global outbreaks.
- Holm RH, Osborne Jelks N, Schneider R, Smith T. Beyond COVID-19: Designing Inclusive Public Health Surveillance by Including Wastewater Monitoring. Health Equity. 2023 Jun 15;7(1):377-379. doi: 10.1089/heq.2022.0055. PMID: 37351532; PMCID: PMC10282970.
Impact Statement: This work emphasizes the importance of expanding wastewater testing to include vulnerable and underserved communities, particularly when clinical testing data are insufficient, in order to ensure rapid response to public health threats and equitable protection of health in the United States.