June 2022 Member Publications
- Bastick JC, Banerjee M, States JC. Zinc supplementation prevents arsenic-induced dysregulation of ZRANB2 splice function. Environ Toxicol Pharmacol. 2022 Jun 25;94:103921. doi: 10.1016/j.etap.2022.103921. Epub ahead of print. PMID: 35764259.
Impact Statement: This publication adds support to the hypothesis that zinc supplementation could mitigate the toxic effects of chronic low level arsenic exposure.
- Jiang M, Li F, Liu Y, Gu Z, Zhang L, Lee J, He L, Vatsalya V, Zhang HG, Deng Z, Zhang X, Chen SY, Guo GL, Barve S, McClain CJ, Feng W. Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation. Hepatology. 2022 Jun 11. doi: 10.1002/hep.32608. Epub ahead of print. PMID: 35689610.
Impact Statement: Intestinal farnesoid X receptor (FXR) plays a critical role in alcohol-associated liver disease (ALD). We aimed to investigate whether alcohol-induced dysbiosis increased intestinal microRNA194 (miR194) that suppressed Fxr transcription and whether Lactobacillus rhamnosus GG-derived exosome-like nanoparticles (LDNPs) protected against ALD through regulation of intestinal miR194-FXR signaling in mice.
- Sutaria SR, Gori SS, Morris JD, Xie Z, Fu XA, Nantz MH. Lipid Peroxidation Produces a Diverse Mixture of Saturated and Unsaturated Aldehydes in Exhaled Breath That Can Serve as Biomarkers of Lung Cancer-A Review. Metabolites. 2022 Jun 18;12(6):561. doi: 10.3390/metabo12060561. PMID: 35736492; PMCID: PMC9229171.
Impact Statement: The paper provides a comprehensive review of saturated and unsaturated aldehydes in exhaled breath and their sources from lipid peroxidation. Some of these aldehydes in exhaled breath have been reported as biomarkers of lung cancer.
- Wise JTF, Salazar-González RA, Walls KM, Doll MA, Habil MR, Hein DW. Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells. Toxicol Appl Pharmacol. 2022 Jun 2;449:116095. doi: 10.1016/j.taap.2022.116095. Epub ahead of print. PMID: 35662664.
Impact Statement: Human carcinogens to which humans are exposed by inhalation include 4-aminobiphenyl, β-naphthylamine and hexavalent chromium. Whereas the effects of the individual carcinogens have been investigated, this study investigated the effects of co-exposure of these carcinogens in human lung cells. The study documented that hexavalent chromium increased N-acetyltransferase 1 activity contributing to increased genotoxicity from 4-aminobiphenyl or β-naphthylamine.
- Yan K, Mei Z, Zhao J, Prodhan MAI, Obal D, Katragadda K, Doelling B, Hoetker D, Posa DK, He L, Yin X, Shah J, Pan J, Rai S, Lorkiewicz PK, Zhang X, Liu S, Bhatnagar A, Baba SP. Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart. J Am Heart Assoc. 2022 Jun 22:e023868. doi: 10.1161/JAHA.121.023868. Epub ahead of print. PMID: 35730646.
Impact Statement: To identify histidyl dipeptide-mediated responses in the heart, we used an integrated triomics approach, which involved genome-wide RNA sequencing, global proteomics, and unbiased metabolomics to identify the effects of cardiospecific transgenic overexpression of the carnosine synthesizing enzyme, carnosine synthase (Carns), in mice. Our result showed that higher myocardial levels of histidyl dipeptides were associated with extensive changes in the levels of several microRNAs, which target the expression of contractile proteins, β-fatty acid oxidation, and citric acid cycle (TCA) enzymes. Global proteomic analysis showed enrichment in the expression of contractile proteins, enzymes of β-fatty acid oxidation, and the TCA in the Carns transgenic heart. Integration of multiple data sets suggested that β-fatty acid oxidation and TCA pathways exhibit correlative changes in the Carns transgenic hearts at all 3 levels. Conclusions Taken together, these findings reveal a central role of histidyl dipeptides in coordinated regulation of myocardial structure, function, and energetics.
- Kumar R, Adhikari S, Driver EM, Smith T, Bhatnagar A, Lorkiewicz PK, Xie Z, Hoetker JD, Halden RU. Towards a novel application of wastewater-based epidemiology in population-wide assessment of exposure to volatile organic compounds. Sci Total Environ. 2022 Jun 27:157008. doi: 10.1016/j.scitotenv.2022.157008. Epub ahead of print. PMID: 35772546.
Impact Statement: This is the first study to utilize wastewater to detect urinary biomarkers of volatile organic compounds (VOCs) exposure. These preliminary results suggest the wastewater-based epidemiology approach as a potentially powerful tool to assess community health exposures to indoor and outdoor air pollutants.
- Polivka BJ, Huntington-Moskos L, Antimisiaris DE, Cavallazzi RS, Folz RJ. Phenotyping older adults with asthma by means of cluster analysis. Ann Allergy Asthma Immunol. 2022 Jun 10:S1081-1206(22)00501-4. doi: 10.1016/j.anai.2022.06.003. Epub ahead of print. PMID: 35697194.
Impact Statement: Whereas a number of publications have identified asthma phenotypes in adults, few have focused only on older adults. As a component of a randomized controlled trial of older adults (≥50 years old) with persistent asthma, Baptist et al identified 4 phenotypic clusters. The purpose of this study was to compare findings from the Baptist et al study with cluster analysis findings from a cohort of older adults with asthma participating in a longitudinal observational study.
- McLeish KR, Shrestha R, Vashishta A, Rane MJ, Barati MT, Brier ME, Lau MG, Hu X, Chen O, Wessel CR, Spalding T, Bush SE, Ijemere K, Hopkins CD, Cooke EA, Tandon S, Manning T, Uriarte SM, Huang J, Yan J. Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients. Front Immunol. 2022 May 31;13:879686. doi: 10.3389/fimmu.2022.879686. PMID: 35711435; PMCID: PMC9197482.
Impact Statement: Normal Density Neutrophils and Low Density Neutrophils from COVID-19 patients possess complementary functional capabilities that may act cooperatively to determine disease severity. We predict that global neutrophil responses that induce COVID-19 ARDS will vary depending on the proportion of neutrophil subsets.
- Brady MP, Chava S, Tandon S, Rane MJ, Barati MT, Caster DJ, Powell DW. Serum and Urine Interferon Gamma-Induced Protein 10 (IP-10) Levels in Lupus Nephritis. J Clin Med. 2022 Jun 3;11(11):3199. doi: 10.3390/jcm11113199. PMID: 35683585; PMCID: PMC9181282.
Impact Statement: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus and current diagnostics and treatments are inadequate. Our report identifies a potential diagnostic marker for LN and will therefore provide impactful insight for improved LN patient care.
Watson WH, Ritzenthaler JD, Torres-Gonzalez E, Arteel GE, Roman J. Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury. Alcohol Clin Exp Res. 2022 Jun 20. doi: 10.1111/acer.14893. Epub ahead of print. PMID: 35723023.
Impact Statement: Liver disease associated with long-term heavy drinking of alcoholic beverages is a major health problem with no FDA-approved therapies. In this paper, we describe a previously unknown mediator of alcohol’s adverse effects on the liver: the alpha4 subunit of nicotinic acetylcholine receptors. These neurotransmitter receptors are known to be important in the brain, where they are involved in the reward pathways activated by both nicotine and alcohol. The discovery that they are also expressed in the liver and contribute to some of the earliest manifestations of alcohol-associated liver disease points to a new target for potential therapeutic interventions.
- Rajesh M, Xin Y, Young JL, Cai L. Editorial: Cardiovascular Diseases Related to Diabetes and Obesity. Front Endocrinol (Lausanne). 2022 May 23;13:916142. doi: 10.3389/fendo.2022.916142. PMID: 35677720; PMCID: PMC9169566.
Impact Statement: Worldwide, the prevalence of obesity continues rising unabated due to the rapid urbanization in the developed and developing countries and poor lifestyle habits. Obesity is also attributed to the development of major cardiovascular diseases (CVD), diabetes, arthritis, behavioral changes, depression, cancers, and hepatic diseases. Therefore, a special issue focus on the CVDs related to diabetes and obesity has been released, for which this editorial was and also briefly introduced the contents of the twelve publications, with a hope to set the stage for delving further in deciphering the crucial link between obesity and diabetes.