April 2022 Member Publications
- Dwenger MM, Raph SM, Reyzer ML, Lisa Manier M, Riggs DW, Wohl ZB, Ohanyan V, Mack G, Pucci T, Moore JB 4th, Hill BG, Chilian WM, Caprioli RM, Bhatnagar A, Nystoriak MA. Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism. Nat Commun. 2022 Apr 19;13(1):2051. doi: 10.1038/s41467-022-29745-z. PMID: 35440632; PMCID: PMC9018695.
Impact Statement: This study shows that coronary dilation to increase myocardial blood flow during increased contractile demand is controlled by voltage-gated potassium channel. This metabolic sensitivity of the potassium channel is due to the ancillary subunits that bind to pyridine nucleotides to alter the gating characteristics of the channel.
- Wang K, Sun S, Zhang G, Lu Z, Chen H, Fan X, Gu C, Pan X, Lin Q, Chen O, Cai L, Dai X, Wang X, Lu C, Yan X, Tan Y. CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells via Activating Akt/eNOS Pathway and Promotes Ischemic Angiogenesis in Diabetic Limb Ischemia. Cardiovasc Drugs Ther. 2022 Apr 26. doi: 10.1007/s10557-022-07337-9. Epub ahead of print. PMID: 35471717.
Impact Statement: Endothelial progenitor cells (EPCs) play a critical role in repairing damaged vessels and triggering ischemic angiogenesis, but their number is reduced, and function is impaired under diabetic conditions. Improving EPC function has been considered a promising strategy to ameliorate diabetic vascular complications. In the present study, we showed that CXCR7 agonist TC14012 can prevent EPCs from high level of glucose-induced dysfunction and apoptosis, improve eNOS activity and NO production via CXCR7/Akt signal pathway, and promote EPC mobilization and diabetic ischemia angiogenesis.
- Lustig RH, Collier D, Kassotis C, Roepke TA, Ji Kim M, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol. 2022 May;199:115012. doi: 10.1016/j.bcp.2022.115012. Epub 2022 Apr 5. PMID: 35393120; PMCID: PMC9050949.
Impact Statement: The review article examines the molecular mechanisms contributing to obesity that may be impacted by environmental chemicals.
- Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Ji Kim M, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015. Epub 2022 Apr 5. PMID: 35395240.
Impact Statement: This review article examines the evidence that environmental chemicals have contributed to obesity.
- Polivka BJ, Huntington-Moskos L, Folz R, Barnett R. CE: Environments & Health: Chemicals in the Home That Can Exacerbate Asthma. Am J Nurs. 2022 May 1;122(5):34-39. doi: 10.1097/01.NAJ.0000829776.73698.e0. PMID: 35394947.
Impact Statement: The authors describe how the use of cleaning and disinfectant products may affect asthma and asthma-related symptoms and report the findings of a recent study they conducted that identified how these products could reduce asthma control in older adults.
- Eldeirawi KM, Nyenhuis SM, Huntington-Moskos L, Polivka BJ. COVID-19 Related Anxiety Is Associated with Uncontrolled Asthma in Adults. Ann Allergy Asthma Immunol. 2022 Apr 22:S1081-1206(22)00308-8. doi: 10.1016/j.anai.2022.04.011. Epub ahead of print. PMID: 35470038; PMCID: PMC9033292.
Impact statement: The COVID-19 pandemic has disproportionately affected people with chronic diseases, including asthma; these impacts were both physically and psychologically. Our findings underscore the need for health care providers to assess for the ongoing psychological impact of the pandemic and refer to mental health specialists.
- Hodges NA, Lampejo AO, Shang H, Rowe G, LeBlanc AJ, Katz AJ, Murfee WL. Viewing Stromal Vascular Fraction de novo Vessel Formation and Association with Host Microvasculature Using the Rat Mesentery Culture Model. Microcirculation. 2022 Apr 25:e12758. doi: 10.1111/micc.12758. Epub ahead of print. PMID: 35466504.
Impact Statement: This study describes the use of the rat mesentery culture model as a novel tool to investigate cell therapy transplantation. Additionally, this model allows us to visualize many different cell types that are involved in microvascular growth over time using time-lapse microscopy.
- Shiri F, Feng H, Petersen KE, Sant H, Bardi GT, Schroeder LA, Merchant ML, Gale BK, Hood JL. Separation of U87 glioblastoma cell-derived small and medium extracellular vesicles using elasto-inertial flow focusing (a spiral channel). Sci Rep. 2022 Apr 12;12(1):6146. doi: 10.1038/s41598-022-10129-8. PMID: 35414673; PMCID: PMC9005724.
Impact Statement: Developing advanced methods to isolate nanoscale and microscale cell-derived extracellular vesicle (EV) types and subtypes are of significant interest to the EV research community in general given their functional, diagnostic and therapeutic potential. The elasto-inertial focusing system developed in the manuscript is a novel compact microfluidic device that mechanistically works like gold standard differential ultracentrifugation for EV isolation. Because of its compact size, it can potentially be integrated with other microfluidic lab-on-a-chip and similar technologies to enable scalable, continuous separation of small microliter to milliliter volume limited samples upstream or downstream on EV chip-based detection and capture devices.
- Lin Q, Chen O, Wise JP Jr, Shi H, Wintergerst KA, Cai L, Tan Y. FGF1ΔHBS delays the progression of diabetic nephropathy in late-stage type 2 diabetes mouse model by alleviating renal inflammation, fibrosis, and apoptosis. Biochim Biophys Acta Mol Basis Dis. 2022 Apr 18;1868(8):166414. doi: 10.1016/j.bbadis.2022.166414. Epub ahead of print. PMID: 35447340.
Impact Statement: Elderly adults are at higher risk for developing diabetic complications including diabetic nephropathy (DN), contributing to excess morbidity and mortality in elderly individuals. A non-mitogenic variant of fibroblast growth factor 1 (FGF1ΔHBS) was found to prevent DN in an early-stage (2-month-old) type 2 diabetes (T2D) mouse model. The present study demonstrated that FGF1ΔHBS was also able to delay the progression of renal dysfunction likely through activating PPARα to prevent renal tubule cell death in late-stage T2D, exhibiting a promising translational potential in treating DN in elderly T2D individuals by ameliorating renal inflammation, fibrosis, and apoptosis.
- Faleye TOC, Driver EM, Bowes DA, Holm RH, Talley D, Yeager R, Bhatnagar A, Smith T, Varsani A, Halden RU, Scotch M. Detection of Human, Porcine and Canine Picornaviruses in Municipal Sewage Sludge Using Pan-Enterovirus Amplicon-based Long-read Illumina Sequencing. Emerg Microbes Infect. 2022 Apr 27:1-25. doi: 10.1080/22221751.2022.2071173. Epub ahead of print. PMID: 35475464.
Impact Statement: The findings of this paper show that sludge from different stages wastewater treatment can be used for surveillance of viruses from humans and other animals. These results could be applied to improve population coverage and cost-effectiveness of largescale wastewater surveillance for viral disease outbreaks.
- Zhang Y, Mo Y, Yuan J, Zhang Y, Mo L, Zhang Q. MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells. Nanotoxicology. 2021 Dec;15(10):1380-1402. doi: 10.1080/17435390.2022.2030822. Epub 2022 Feb 2. PMID: 35108494.
Impact Statement: Copper oxide nanoparticles (Nano-CuO) are widely used in medical and industrial fields and our daily necessities. However, the biosafety assessment of Nano-CuO is far behind their rapid development. Our study demonstrated that Nano-CuO exposure caused mitochondrial ROS generation, MAPKs activation, and MMP-3 upregulation. Nano-CuO exposure also caused cells to undergo EMT, which was through Nano-CuO-induced dysregulation of ROS/MAPKs/MMP-3 pathway. Our findings will provide further understanding of the potential mechanisms involved in metal nanoparticle-induced various toxic effects including EMT and pulmonary fibrosis.