April 2021 Member Publications
- Tarran R, Barr RG, Benowitz NL, Bhatnagar A, Chu HW, Dalton P, Doerschuk CM, Drummond MB, Gold DR, Goniewicz ML, Gross ER, Hansel NN, Hopke PK, Kloner RA, Mikheev VB, Neczypor EW, Pinkerton KE, Postow L, Rahman I, Samet JM, Salathe M, Stoney CM, Tsao PS, Widome R, Xia T, Xiao D, Wold LE. E-Cigarettes and Cardiopulmonary Health. Function (Oxf). 2021 Feb 8;2(2):zqab004. doi: 10.1093/function/zqab004. PMID: 33748758; PMCID: PMC7948134.
Impact Statement: This article describes the proceedings and discussions at an NIH workshop on e-cigarette. The paper reviews current evidence relating the use of e-cigarettes to cardiovascular and pulmonary health and how to address major gaps in our knowledge of the long-term health effects of e-cigarettes.
Jiang C, Liu G, Cai L, Deshane J, Antony V, Thannickal VJ, Liu RM. Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. Am J Pathol. 2021 Apr 20:S0002-9440(21)00154-1. doi: 10.1016/j.ajpath.2021.04.003. Epub ahead of print. PMID: 33887217
Impact Statement: This study revealed that increased PAI-1 expression may contribute to the apoptosis paradox observed in idiopathic pulmonary fibrosis (IPF) and aging lungs through dichotomous regulation of p53 expression in these cells, which supports the critical role of PAI-1 in IPF pathophysiology and suggests that small molecule PAI-1 inhibitors may have therapeutic potential for IPF.
- Duan X, Wei N, Wei J, Zhu Y, Kang Y, He Y, Huang J, Wang S. Effect of High-Flow Nasal Cannula Oxygen Therapy on Pediatric Patients With Congenital Heart Disease in Procedural Sedation: A Prospective, Randomized Trial. J Cardiothorac Vasc Anesth. 2021 Mar 27:S1053-0770(21)00273-1. doi: 10.1053/j.jvca.2021.03.031. Epub ahead of print. PMID:33934982.
Impact Statement: This study looks at how High flow nasal cannula is effective for pediatric patients with non-cyanotic congenital heart disease who require procedural sedation.
- Xu Q, Samanapally H, Nathala P, Salunkhe V, Furmanek S, Cahill MN, McGuffin T, Mohammad T, Marsili B, Petrey J, Carrico R, Ramirez J, Akca O, Clifford SP, Pahwa S, Roser L, Kong M, Huang J; Center of Excellence for Research in Infectious Diseases (CERID) Coronavirus Study Group on behalf of the COVID-19 CardioVascular Research Group (COVID-CVRG). Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients. J Cardiothorac Vasc Anesth. 2021 Mar 27:S1053-0770(21)00277-9. doi: 10.1053/j.jvca.2021.03.035. Epub ahead of print. PMID: 33867235; PMCID: PMC7997853.
Impact Statement: This study found cardiovascular events were prevalent and associated with worse outcomes in hospitalized patients with COVID-19. Outcomes of cardiovascular events in African American and white COVID-19 patients were similar after propensity score matching analysis. There were common and unique risk factors for cardiovascular events in African American COVID-19 patients when compared with white patients.
- Latif RK, Clifford SP, Byrne KR, Maggard B, Chowhan Y, Saleem J, Huang J. Hyperoxia After Return of Spontaneous Circulation in Cardiac Arrest Patients. J Cardiothorac Vasc Anesth. 2021 Mar 8:S1053-0770(21)00209-3. doi: 10.1053/j.jvca.2021.03.007. Epub ahead of print. PMID: 33875350.
Impact Statement: This article looks at a strategy of precise control of arterial oxygenation where O2 therapy is titrated against a pre-specified PaO2 or SaO2 target range has been provided to healthcare providers. The best PaO2 target may vary based on patientrelated factors, such as age, severe cardiac ischemia, cerebral ischemia, pulmonary edema or untreated anemia.
Jala VR, Bodduluri SR, Ghosh S, Chheda Z, Singh R, Smith ME, Chilton PM, Fleming CJ, Mathis SP, Sharma RK, Knight R, Yan J, Haribabu B. Absence of CCR2 reduces spontaneous intestinal tumorigenesis in the ApcMin/+ mouse model. Int J Cancer. 2021 Jan 26. doi: 10.1002/ijc.33477. Epub ahead of print. PMID: 33497467
Impact Statement: In this paper, we showed that deletion of chemokine receptor (CCR2), which is responsible for migration of inflammatory macrophages to the tumor sites, significantly reduced colon tumor burden and progression and increased overall survival of colon cancer mice. In addition, we also identified novel role for CCR2 in migration of Th17 cells (known to promote colonic inflammation and colon tumors) into tumors, where deletion of CCR2 significantly reduced these cells and promoted tumor killing CD8+ T cells. Therefore, targeting CCR2 in colon cancer patients potentially reduce tumor burden and benefit the patients.
- Abdel-Rahman SM, Paul IM, Hornik C, Sullivan JE, Wade K, Delmore P, Sharma G, Benjamin DK, Zimmerman KO. Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act. Pediatrics. 2021 May;147(5):e2020042903. doi: 10.1542/peds.2020-042903. Epub 2021 Apr 12. PMID: 33846237.
Impact Statement: This study demonstrated enrollment of diverse racial and ethnic populations in pediatric studies conducted with funding from BPCA, fulfilling the legislation's expectation to ensure adequate representation of all children.
- Knight L, Pahud BA, Scheffler M, Euteneuer JC, Allen C, Ross J, Ali W, Meyer M, Purohit PJ, Zimmerman KO, Sullivan JE; ECHO IDeA States Pediatric Clinical Trials Network. Capacity Building in a New Clinical Trials Network Through Inter-Network Collaboration. J Pediatr. 2021 Apr 30:S0022-3476(21)00414-5. doi: 10.1016/j.jpeds.2021.04.062. Epub ahead of print. PMID: 33940019.
Impact Statement: This publication reflects the positive impact of inter-network collaboration and mentoring of an established network with a new network which allowed for substantial growth and resources for the new network
- Zhou B, Gentry A, Xu Q, Young JL, Yan X, Pagidas K, Yang Y, Watson WH, Kong M, Cai L, Freedman JH. Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis. Toxicol Rep. 2021 Mar 20;8:718-723. doi: 10.1016/j.toxrep.2021.03.016. PMID: 33889501; PMCID: PMC8047427.
Impact Statement: This report addresses the impact of environmental factors on the increasing prevalence male infertility.
Speer RM, Toyoda JH, Croom-Perez TJ, Liu KJ, Wise JP. Particulate Hexavalent Chromium Inhibits E2F1 Leading to Reduced RAD51 Nuclear Foci Formation in Human Lung Cells. Toxicol Sci. 2021 Apr 27;181(1):35-46. doi: 10.1093/toxsci/kfab019. PMID: 33677506; PMCID: PMC8081024.
Impact Statement: Chromium is a known human carcinogen that is common in our environment, but we do not know how it causes cancer. A key toxic action of chromium is to damage DNA strands while simultaneously inhibiting the repair of that damage, but we do not know how chromium inhibits this repair. This study provides an important step forward in understanding how chromium inhibits that repair.