Recent Publications

Fungal Research

Relevant Publications

Smith, D.G., Garcia-Pedrajas, M.D., Gold, S.E., and Perlin, M.H. 2003. Isolation and Characterization  from Pathogenic Fungi of Genes encoding Methylammonium Permeases and their roles in Dimorphism. Mol. Micro. 50:259-275.

Smith,D., Hong, W., Garcia-Pedrajas, M.D., Gold, S.E., and Perlin, M.H. 2004. A ste20 homologue in Ustilago maydis plays a role in dimorphism and pathogenicity. Euk. Cell 3:180-189.

Hughes, C.F., and M.H. Perlin. 2005. Differential expression of mepA, mepC, and smtE during growth and development of Microbotryum violaceum. Mycologia 97: 605-611.

Kämper, J., R.Kahmann, M.Bölker, B. J.Saville, F.Banuett, J. W.Kronstad, S. E.Gold, M.H. Perlin et al. 2006. Living in pseudoharmony: the genome of the biotrophic fungus Ustilago maydis. Nature, 444:97-101.

Klosterman, S.J.,  M.H. Perlin, M. Garcia-Pedrajas, S. F. Covert and S. E. Gold. 2007. Genetics of morphogenesis and pathogenic development of Ustilago maydis. Adv Genet. 571-47.

Garcia-Pedrajas, M.D., M.  Nadal, L. B Kapa, M.H. Perlin, D. L. Andrews, S. E. Gold. 2008.  DelsGate, a robust and rapid gene deletion construction method. Fungal Genetics Biol. 45: 379-388.

Garcia-Pedrajas, M.D., M.  Nadal, M. Bölker, S. E. Gold, M.H. Perlin. 2008. Sending mixed signals: Redundancy vs. uniqueness of signaling components in the plant pathogen, Ustilago maydis. Fungal Genetics Biol. 45(Supplement 1): S22-S30.

Pham, C.D., Z, Yu, B. Sandrock, M. Bölker, S. E. Gold, and M.H. Perlin. 2009.Ustilago maydis Rho1 and 14-3-3 homologues participate in pathways controlling cell separation and cell polarity. Eukaryot. Cell 8: 977-989.

Pham, C.D. and M.H. Perlin. 2010. Possible additional roles in mating for Ustilago maydis Rho1 and 14-3-3 homologues. Communicative and Integrative Biology. 3(1): 57 - 59 DOI: 10.4161/cib.3.1.9864

Garcia-Sanchez MA, Martin-Rodrigues N, Ramos B, Vega-Bartol JJ, Perlin MH, Diaz-Minguez JM. 2010. Fost12, the Fusarium oxysporum homologue of the transcription factor Ste12, is upregulated during plant infection and required for virulence.  Fungal Genet. Biol. 47(3): 216-25

Pham, C.D., J.T. Dixon and M.H. Perlin. 2010. The many and varied roles of Rho GTPases in fungi and a comprehensive review of their regulation. Curr. Trends in Microbiol. 5: 1-17

Agarwal, C, D J Schultz, and M.H. Perlin. 2010.  Two phosphodiesterases from Ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases. Front. Microbio. DOI: 10.3389/fmicb.2010.00127

Lovely, C.B., K.B. Aulakh, and M.H. Perlin. 2011. The Role of Hsl7 in Morphology and Pathogenicity and its Interaction with other Signaling Components in the Plant Pathogen, Ustilago maydis. Eukaryot. Cell 11: 869-883.

Lovely, C.B. and M.H. Perlin. 2011.  Cla4, but not Rac1, regulates the filamentous response of Ustilago maydis to low ammonium conditions. Communicative and Integrative Biology. 4(6): 1-4.

Pham, C.D., Z. Yu, C. B. Lovely, C. Agarwal, D. A. Myers, J. A. Paul, M. Cooper, M. Barati, and M.H. Perlin. 2012. Haplo-insufficiency for different genes differentially reduces pathogenicity and virulence in a fungal phytopathogen. Fungal Genet. Biol.   DOI: 10.1016/j.fgb.2011.11.007

Petit, E., T. Giraud, D. M. de Vienne, M. A. Coelho, G. Aguileta, J. Amselem, J. Kreplak, J.Poulain, F. Gavory, P. Wincker, S. K. Young, C. Cuomo, M.H. Perlin, and M. E. Hood. 2012. Linkage to the mating-type locus across the genus Microbotryum: insights into nonrecombining chromosomes. Evolution DOI:10.1111/j.1558-5646.2012.01703.x

Agarwal, C., K. B. Aulakh, K. Edelen, M. Cooper , R. M. Wallen, S. Adams, D. J. Schultz, and M.H. Perlin. 2013. Ustilago maydis phosphodiesterases play a role in the dimorphic switch and in pathogenicity. Microbiology 159(Pt 5):857-68. DOI: 10.1099/mic.0.061234-0.  

Paul, J.A., M.T. Barati, M. Cooper, and M.H.Perlin. 2014. Physical and Genetic Interaction between Ammonium Transporters and the Signaling Protein, Rho1, in the Plant Pathogen, Ustilago maydis. Eukaryot. Cell 13:1328-36. DOI: 10.1128/EC.00150-14. 

Fontanillas E, Hood ME, Badouin H, E. Petit, Barbe V,Gouzy J, de Vienne DM, Aguileta G, Poulain J, Wincker P, Chen Z, Toh SS, Cuomo CA, PerlinMH, Gladieux P, Giraud T. 2014. Degeneration of the non-recombining regions in the mating-type chromosomes of the anther-smut fungi. Mol. Biol. Evol. 32(4):928–43 DOI: 10.1093/molbev/msu396  Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Joseph Heitman.

Perlin, MH, J Amselem, E Fontanillas, SS Toh, Z Chen, J Goldberg, S Duplessis, B Henrissat, S Young, Q Zeng, G Aguileta, E Petit, H Badouin, J Andrews, D Razeeq, T Gabaldón, H Quesneville, T Giraud, ME. Hood, DJ Schultz, CA Cuomo. 2015. Sex and Parasites: Genomic and transcriptomic analysis of Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating anther smut fungus. BMC Genomics 16:461

Badouin, H, ME Hood, J Gouzy, G Aguileta, S Siguenza, MHPerlin, CA Cuomo, C Fairhead, A Branca, T Giraud. 2015. Chaos of rearrangements in fungal mating-type chromosomes. Genetics 200:1275-1284.  Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Members Kaustav Sanyal and Vikas Yaday.

Toh, S.S. and M.H. Perlin. 2015.Size Does Matter: Staging of Silene latifolia Floral Buds for Transcriptome Studies. Int. J. Mol. Sci.2015, 16(9), 22027-22045; DOI:10.3390/ijms160922027

 Toh, S.S. and M.H.Perlin. 2016. Resurgence of less-studied smut fungi as models of phytopathogenesis in the –omics era. Phytopathology 106(11):1244-1254.  (Invited Review)

 Toh, S.S., D.S. Treves, M.T. Barati, and M.H.Perlin. 2016. Reliable transformation system for Microbotryum lychnidis‑dioicae informed by genome and transcriptome project. Arch. Microbiol. 198(8): 813–825 1-13. DOI: 10.1007/s00203-016-1244-2

Toh, S.S., Chen, Z. Schultz, D.J., Cuomo, C.A., and Perlin, M.H. 2017. Transcriptional analysis of mating and pre-infection stages of the anther smut, Microbotryum lychnidis-dioicae. Microbiology 163: 410-420, DOI: 10.1099/mic.0.000421

 Toh, S.S., Z. Chen, E.C. Rouchka, D.J. Schultz, C.A. Cuomo, and M.H. Perlin. 2017. Pas de deux: An intricate dance of anther smut and its host.  G3: Genes, Genomes, Genetics: 8:2 505-518;

 Kuppireddy, V.S., V.N. Uversky, S. Toh, M.-C. Tsai, W. C. Beckerson, C. Cahill, B. Carman, and M. H.Perlin. 2017. Identification and initial characterization of effectors of an anther smut fungus and potential host target proteins. Int. J. Mol. Sci. 18, 2489; DOI:10.3390/ijms18112489

 Schirawski, J. and M.Perlin. 2018. Plant Microbe Interaction 2017 – The Good, the Bad and the Diverse. (Editorial, peer-reviewed) Int. J. Mol. Sci. 19, 1374; DOI:10.3390/ijms19051374

Wallen, R.M. and M.H.Perlin. 2018.An overview of the function and maintenance of sexual reproduction in dikaryotic fungi. Front. Microbiol., 21 March 2018 |

Paul, J.A., R.M. Wallen, C. Zhao, T. Shi, and M.H.Perlin. 2018. Coordinate Regulation of Ustilago maydis Ammonium Transporters and Genes Involved in Mating and Pathogenicity. Fungal Biol.

 Vijayakrishnapillai, LMK, JS Desmarais, MN Groeschen, and MHPerlin. 2018. Deletion of ptn1, a PTEN/TEP1 Orthologue, in Ustilago maydis Reduces Pathogenicity and Teliospore Development. J. Fungi 2019, 5, 1; doi:10.3390/jof5010001

 Saville, B. J. and M.H.Perlin. 2019. When worlds collide and smuts converge: Tales from the 1st International Ustilago/Smut Convergence. Fungal Genet. Biol.

 Beckerson, W.C., R. C. Rodríguez de la Vega, F. E. Hartmann, M. Duhamel, T. Giraud, M. H. Perlin. 2019. Cause and Effectors: whole genome comparisons reveal shared but rapidly evolving effector sets among host-specific plant-castrating fungi. mBio 10 (6): e02391-19; DOI: 10.1128/mBio.02391-19

Mendoza, H., M.H. Perlin, and J. Schirawski. 2020. Mitochondrial inheritance in phytopathogenic fungi- everything is known, or is it? Int J Mol Sci 21, 3883; doi:10.3390/ijms21113883


 Evolution of Antibiotic Resistance

Relevant Publications

Dugatkin, L.A., M.H. Perlin and R.M. Atlas. 2003. The evolution of group-beneficial traits in the absence of between-group selection J. Theoret. Biol. 220:67-74.

Nurizzo, D., Shewry, S.C., Perlin, M.H., Brown, S.A., Dholakia, J.N., Fuchs, R.L., Dava, T., Baker, E.N., Smith, C.A. 2003. The crystal structure of aminoglycoside-3’-phosphotransferase-IIa, an enzyme responsible for antibiotic resistanceJ. Mol. Biol. 327:491-506.

Dugatkin, L.A., Perlin, M.H., Lucas, J.S. and Atlas, R.M. 2005. Group-beneficial Traits, Frequency-Dependent Selection and Genotypic Diversity: An Antibiotic Resistance Paradigm . Proc. Roy. Soc. London. 272:79-83.

Dugatkin, L.A., M.H. Perlin,, and R.M. Atlas. 2005. Antibiotic resistance and the evolution of group-beneficial traits. II: A metapopulation model.J. Theoret. Biol. 236:392-6.

Dugatkin, L.A., Dugatkin, A.D., Atlas, R.M., Perlin, M.H. 2008 Cheating on the Edge. PLoSOne3, e2763.

Clark, D.R., Alton, T.M., Bajorek, A., Holden, P., Dugatkin, L.A., Atlas, R.M. & Perlin, M.H. 2009 Evolution of altruists and cheaters in near-isogenic populations of Escherichia coli. Frontiers in BioSciences14, 4815-4824.

Perlin, MH, D. R. Clark, C. McKenzie, H. Patel, N. Jackson, C. Kormanik, C. Powell, A. Bajorek, D. A. Myers, L. A. Dugatkin, and R. M. Atlas. 2009. Protection of Salmonella by ampicillin-resistant E. coli in the presence of otherwise lethal drug concentrations. Proc. Roy. Soc. London.

Brown, S.A., J.N. Dholakia, and M.H. Perlin. 2010.. Photoaffinity labeling of Aminoglycoside Phosphotransferase 3’-II with azido ATP confirms the involvement of conserved lysine in ATP binding.J Biochem Tech 2(4):190-195. Published online: 8 February 2011,© Sevas Educational Society 2008-2010