Roberto Bolli, MD, FAHA

Roberto Bolli, M.D., FAHA has been Chief of Division of Cardiology at the University of Louisville since 1994.  Dr. Bolli serves as Vice Chairman for Research of the Department of Medicine, a distinguished University Scholar, and the Jewish Hospital Distinguished Chair in Cardiology at the University of Louisville. Dr. Bolli is or has been on the editorial board of all major cardiovascular journals and is presently the Editor in Chief of Circulation Research. Dr. Bolli has been a member of numerous NIH study sections and committees and is presently a member of the NHLBI Advisory Council. He serves as a member of the Board of Directors of the American Heart Association. He is a member of the American Society for Clinical Investigation and the association of American Physicians, and a Foreign Fellow of the academy of Sciences of the Royal Society of Canada. Dr. Bolli’s honors include the 1987 Physician Scientist Award of the American College of Chest Physicians, the 2001 Basic Research Prize of the American Heart Association, the 2004 Research Achievement Award of the international Society for Heart Research, and the 2006 Distinguished Achievement Award of the American Heart Association. Dr. Bolli graduated from the University of Perugia (Italy) in 1976.

Selected Recent Publications:

• Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima JA, Slaughter MS, Anversa P, Bolli R., Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation.  2012 Sep 11;126(11 Suppl 1):S54-64.
• Guo Y, Flaherty MP, Wu WJ, Tan W, Zhu X, Li Q, Bolli R. Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice. Basic Res Cardiol. 2012 Sep;107(5):288. doi: 10.1007/s00395-012-0288-y. Epub 2012 Aug 3.
• Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, Beache GM, Wagner SG, Leri A, Hosoda T, Sanada F, Elmore JB, Goichberg P, Cappetta D, Solankhi NK, Fahsah I, Rokosh DG, Slaughter MS, Kajstura J, Anversa P. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011 Nov 26;378(9806):1847-57. Epub 2011 Nov 14.
• Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, Dai S, Li C, Chen N, Peng Y, Dawn B, Hunt G, Leri A, Kajstura J, Tiwari S, Shirk G, Anversa P, Bolli R. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. 2010 Jan 19;121(2):293-305. Epub 2010 Jan 4.
• Li Q, Guo Y, Ou Q, Cui C, Wu WJ, Tan W, Zhu X, Lanceta LB, Sanganalmath SK, Dawn B, Shinmura K, Rokosh GD, Wang S, Bolli R. Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway. Circulation. 2009 Sep 29;120(13):1222-30. Epub 2009 Sep 14.
• Li Q, Guo Y, Tan W, Ou Q, Wu WJ, Sturza D, Dawn B, Hunt G, Cui C, Bolli R. Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway. Circulation. 2007 Oct 2;116(14):1577-84. Epub 2007 Sep 4.
• Dawn B, Guo Y, Rezazadeh A, Huang Y, Stein AB, Hunt G, Tiwari S, Varma J, Gu Y, Prabhu SD, Kajstura J, Anversa P, Ildstad ST, Bolli R. Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res. 2006 Apr 28;98(8):1098-105. Epub 2006 Mar 23.
• Jneid H, Chandra M, Alshaher M, Hornung CA, Tang XL, Leesar M, Bolli R. Delayed preconditioning-mimetic actions of nitroglycerin in patients undergoing exercise tolerance tests. Circulation. 2005 May 24;111(20):2565-71. Epub 2005 May 16.
• Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R. Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3766-71. Epub 2005 Feb 25.
• Bolli R. The new circulation research: a manifesto. Circ Res. 2010 Feb 5;106(2):216-26.