Dr. Barski
Oleg Barski, Ph.D.
Assistant Professor of Medicine
Tel.: (502) 852-5724
E-mail: o.barski@louisville.edu
Dr. Barski received a M.Sc. in Chemistry in 1987 and a Ph.D. in Chemical Kinetics and Catalysis in 1991 at the Chemical Department, Moscow State University, Russia.
Dr. Barski is studying the link between metabolism and electrical activity of the cell via the beta subunits of voltage-gated potassium channels (KvĪ²). Beta subunits belong to the aldo-keto reductase superfamily and possess high affinity to pyridine nucleotides and catalytic activity with carbonyl substrates. The object of the study is to explore the connection between the oxidoreductase properties of the beta subunit and potassium channel conductance, which allows beta subunit to perform its function of metabolic sensor for potassium channels.
Publications:
1. Barski O.A., Papusha V.Z., Ivanova M.M., Rudman D.M., and Finegold M.J. Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. Am. J. Physiol. Renal Physiol. 289 (1), F200-207 (2005).
2. Barski O.A., Tipparaju S. M., Bhatnagar A. The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metab. Rev. 40 (4), 553-624 (2008).
3. Baba S.P., Barski OA, Ahmed Y., O'Toole T.E., Conklin D.J., Bhatnagar A., Srivastava S. Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue. Diabetes 58 (11), 2486-97 (2009).
