Department of Biochemistry and Molecular Biology

Professor

Email Dr.Kenneth Ramos
Phone Number: 502-852-5217
Fax: 502-852-6222

Address: Baxter Biomedical Research Bldg, Suite 221
Louisville, KY 40202

PhD, 1983 University of Texas

Area of Interest:

Investigators:
Roy Joseph
Adrian Nanez
Charles Partridge
Vilius Stribinskis
Marlene Stephan

Selected Publications:

Johnson, C.D., Balagurunathan, Y., Tadesse, M., Falahatpisheh, M.H., Brun, M., Walker, M., Dougherty, E.R. and Ramos, K.S. Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor. EHP:Toxicogenomics 112, 403-412, 2004.

Jones, S. A., Patterson, J.L., Ramos, K.S. and Wilson, E. Modulation of ERK1.2 and cell cycle regulatory proteins in oxidatively stressed vascular smooth muscle cells. Journal of Cellular Biochemistry 91, 1248-1259, 2004.

Weber, T.J., Negash, S., Smallwood, H.S., Ramos, K.S., Thrall, B.D. and Squier, T.C. Calmodulin involvement in stress-activated nuclear localization of albumin in JB6 epithelial cells. Biochemistry 2004 Jun 15;43(23):7443-502004.

Falahatpisheh, H. M. and Ramos, K.S. Ligand activated Ahr signaling leads to disruption of nephrogenesis and altered Wilms’ tumor suppressor gene splicing. Oncogene 14, 2160-2171, 2003.

Johnson, C.D., Tadesse, M., Falahatpisheh, M.H., Balagurunathan, Y., Lu, K.P., Carroll, R.J., Dougherty, E.R., Afshari, C.A. & Ramos, K.S. (2003) Genomic profiles and predictive biological networks in oxidant-induced atherogenesis. Physiological Genomics 13, 263-275

Lu, K.P. and Ramos, K.S. Redox activation of a novel A-type mouse L1Md retrotransposon in vascular smooth muscle cells. Journal of Biological Chemistry 278, 28201-28209, 2003.

Kondraganti SR, Fernandez-Saluguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy B. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Int J Cancer. 2003 Jan 1;103(1):5-11.

Holderman MT, Miller KP, Dangott LJ, Ramos KS. Identification of albumin precursor protein, Phi AP3, and alpha-smooth muscle actin as novel components of redox sensing machinery in vascular smooth muscle cells. Mol Pharmacol. 2002 May;61(5):1174-83.

Parrish AR, Alejandro NF, Bral CM, Kevin Kerzee J, Bowes RC, Ramos KS. Characterization of glomerular cell phenotypes following repeated cycles of benzo[a]pyrene injury in vitro. Biochem Pharmacol. 2002 Jul 1;64(1):31-9.

Wilson E, Parrish AR, Bral CM, Williams ES, Ramos KS. Collagen suppresses the proliferative phenotype of allylamine-injured vascular smooth muscle cells. Atherosclerosis. 2002 Jun;162(2):289-97.

Holderman MT, Miller KP, Dangott LJ, Ramos KS. Identification of albumin precursor protein, Phi AP3, and alpha-smooth muscle actin as novel components of redox sensing machinery in vascular smooth muscle cells. Mol Pharmacol. 2002 May;61(5):1174-83.

Moorthy B, Miller KP, Jiang W, Ramos KS. The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. Cardiovasc Res. 2002 Mar;53(4):1002-9.

Lu KP, Alejandro NF, Taylor KM, Joyce MM, Spencer TE, Ramos KS. Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes. Atherosclerosis. 2002 Feb;160(2):273-80.

Kerzee JK, Ramos KS. Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor. Circ Res. 2001 Sep 28;89(7):573-82.

Fan YY, Ramos KS, Chapkin RS. Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr. 2001 Jun;131(6):1675-81.

Falahatpisheh MH, Donnelly KC, Ramos KS. Antagonistic interactions among nephrotoxic polycyclic aromatic hydrocarbons.J Toxicol Environ Health A. 2001 Apr 6;62(7):543-60.