Alan Cheng, PhD
Assistant Professor
Phone Number:
Office: 502-852-3572
Fax: 502-852-6222
Address: 319 Abraham Flexner Way, HSC-A 715, Louisville, KY 40202
Ph.D., 2003, McGill University, Canada
Research Interests
Independent research program: Regulation of hepatic glucose and lipid metabolism by carbohydrate binding module containing proteins
Laboratory Personnel
Xiao Guo, Armaghan Fazal, Amber Kelly
Area of Interest
The biochemistry and biology of liver metabolism, diabetes and obesity.
Selected Publications
Cheng A, Zhang M, Okubo M, Omichi K and Saltiel AR. (2009) Distinct mutations in the glycogen debranching enzyme found in Glycogen Storage Disease Type III lead to impairment in diverse cellular functions. Human Molecular Genetics, doi: 10.1093/hmg/ddp128.
Cheng A and Saltiel AR. (2009) Von Gierke’s disease adopts an orphan (and its partner). Science Signaling, 2(58): pe8
Cheng A, Zhang M, Gentry MS, Worby CA, Dixon, JE and Saltiel AR. (2007) A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease. Genes and Development, 21(19):2399-409
*Cheng A, *Zhang M, Crosson SM, Bao ZQ, and Saltiel AR (2006) Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3’,5’-cyclic adenosine 5’-monophosphate in H4IIE hepatoma cells. Endocrinology 147(7):3606-12
Cheng A and Saltiel AR. (2006) More TORC for the gluconeogenic engine. Bioessays 28(3):231-4
Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, and Saltiel AR (2005) Changes in integrin expression during adipocyte differentiation. Cell Metabolism 2(3):165-177
Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, McGlade CJ, Kennedy BP, and Tremblay ML (2002) Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B. Developmental Cell 2(4):497-503
Tsukiyama-Kohara K., Poulin P., Kohara M., DeMaria CT., Cheng A., Wu Z., Gingras A-C., Katsume A., Elchebly M., Spiegelman BM., Harper M-E., Tremblay ML., and Sonenberg N. (2001) Adipose tissue reduction in mice lacking the translation inhibitor 4E-BP1. Nature Medicine. 7:1128-32
Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283(5407):1544-8
