Zhong-bin Deng, Ph.D.

Education:

 B.S., Yangzhou University, Yangzhou, PR.China, Veterinary Medicine, 1994
M.S., Yangzhou University, Yangzhou, PR.China, Veterinary Medicine, 1997
Ph.D., Soochow University, Suzhou, PR.China, Immunology, 2003
Postdoctoral Fellowship, University of Alabama at Birmingham, 2007
Instructor, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 2010

Curriculum Vitae

Current Positions:

Assistant Professor, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY
Member, James Graham Brown Cancer Center, Louisville, KY

Contact Information:

Clinical Translational Research Building, Room 311
University of Louisville
505 South Hancock St
Louisville, KY 40202, USA
Phone 502-852-8621
Fax 502-852-2123

Email: z0deng01@louisville.edu

Research Description:

We are investigating the role and underlying pathways of the inflammatory tumor microenvironment during colon and breast cancer progression, metastasis formation and anti-cancer therapy. We are interested in increasing efficacy of conventional anti-cancer chemotherapies and immunotherapies mediated by exosome-like nanoparticles transporting chemotherapeutic agents and siRNA in vivo. Our research focuses on the regulation of tumor exosomes, gut microbiota, and inflammation in obesity and obesity-related tumor development, especially colon cancer and colitis.  Our research program encompasses studies on cancer immunotherapy and on obesity-related inflammation.

Representative Publications:

Exosomes andmyeloid cells intumor

a)  Deng Z*, Rong Y, Teng Y, Zhuang X, Samykutty A , Mu J, Zhang L, Cao P, Yan J, Miller D, Zhang HG.  Exosomes miR-126a released from MDSCs induced by DOX treatment promotes lung metastasis.  Oncogene 2017 Feb 2;36(5):639-51. PMID: 27345402.(*: Corresponding author)

b)  Deng Z*,  Mu J, Tseng M, Wattenberg B, Zhuang X, Egilmez NK , Wang Q, Zhang L, Norris J, Guo H, Yan J , Bodduluri H, Miller D, Zhang HG*. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.  Nature Communications 2015 Apr 24;6:6928.PMID: 25907800.PMCID: PMC4410277.(*: Corresponding author)

c)  DengZ, Cheng Z, Xiang X, Yan J, Zhuang X, Liu C, Jiang H, Ju S, Zhang L, Grizzle W, Mobley J, Roman J, Miller D, Zhang HG.  Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression.  American Journal of Pathology 2012 Jan;180(1):390-8. PMID: 22067905.

d)  DengZ*, Pardi R, Cheadle W, Xiang X, Grizzle W, Miller D, Mountz J, Zhang HG*.  Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages. Blood 2011 May 5;117(18):4796-804. PMID: 21403132.  (*: Corresponding author). http://www.bloodjournal.org/content/117/18/4796.long?sso-checked=true.

e)  Teng Y, Ren Y, Xu X, Mu J, Samykutty A, Zhuang X, Deng Z, Zhang L, Merchant M, Yan J, Miller D,  Kumar A, Zhang HG.  Major vault protein (MVP) dependent sorting tumor suppressor miR-193a into tumor exosomes promotes colon cancer progression.  Nature Communications 2017 Feb 17;8:14448. PMID: 28211508

f)  Wang Q, Ren Y, Mu J, Egilmez NK, Zhuang X, Deng Z, Zhang L, Yan J, Miller D, Zhang HG. Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.  Cancer Research 2015 Apr 16;75(12):2520-9. [Epub ahead of print]. PMID: 25883092.

g)  Xiang X, Poliakov A, Liu C, Liu Y, DengZB, Wang J, Cheng Z, Shah SV, Wang GJ, Zhang L, Grizzle WE, Mobley J, Zhang HG.  Induction of myeloid-derived suppressor cells by tumor exosomes.  International Journal of Cancer 2009 June 1;124(11):2621-33. PMID: 19235923. PMCID: PMC2757307.

Exosomes and Gut-Liver axis:

a)  DengZB*, Zhuang X, Ju S, Xiang X, Mu J, Wang Q, Hong J, Zhang L, Kronenberg M, Yan J, Miller D, Zhang HG*.  Intestinal mucus-derived nanoparticles mediate activation of Wnt/β-catenin signaling plays a role in induction of liver NKT cell anergy in mice.  Hepatology 2013 Mar;57(3):1250-61. PMID: 22991247. PMCID: PMC4414328.(*: Corresponding author).

b)  DengZB*, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG*.  Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.  J Immunol 2013 Apr 1;190(7):3579-89. PMID: 23467936. PMCID: PMC4396634. (*: Corresponding author).

c)  Zhuang X, Deng ZB, Mu J, Zhang L, Yan J, Miller D, Feng W, McClain CJ, Zhang HG.  Ginger-derived nanoparticles protect against alcohol-induced liver damage.  J Extracell Vesicles 2015 Nov 25;4:28713. doi: 10.3402/jev.v4.28713. eCollection 2015. PMID: 26610593.

d)  Wang B, Zhuang X, DengZB, Jiang H, Mu J, Wang Q, Xiang X, Guo H, Zhang L, Dryden G, Yan J, Miller D, Zhang HG. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Molecular Therapy 2014 Mar; 22(3):522-34. PMID: 23939022. PMCID: PMC3944329.

e)  DengZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S, Zhuang X, Shah SV, Sun D, Michalek S, Grizzle WE, Garvey T, Mobley J, Zhang HG.  Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin PMC2768161. resistance.  Diabetes 2009 Nov;58(11):2498-505. PMID: 19675137. PMCID:

f)  DengZB, Liu Y, Liu C, Xiang X, Wang J, Cheng Z, Shah SV, Zhang S, Zhang L, Zhuang X, Michalek S, Grizzle WE, Zhang HG.  Immature myeloid cells induced by a high fat diet contribute to liver inflammation.  Hepatology, 2009 Nov; 50(5):1412-20. PMID: 19708080.PMCID: PMC2852608.

Exosomal miRNA and Delivery 

a)  Deng Z, Rong Y, Teng Y, Mu J, Zhuang X,Tseng M, Samykutty A, Zhang L, Yan J, Miller D, Suttles J,and Zhang HG.  Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.  Molecular Therapy2017 Jul 5;25(7):1641-1654. PMID:28274798

b)  Wang Q, Zhuang X, Mu J, DengZB, Jiang H, Xiang X, Wang B, Yan J, Miller D, Zhang HG.  Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.  Nature Communications 2013;4:1867. PMID: 23695661. PMCID: PMC4396627

c)  Jiang H, Wang P, Li X, Wang Q, Deng ZB, Zhuang X, Mu J, Zhang L, Wang B, Yan J, Miller D, Zhang HG.  Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.  Cancer Immunol Res 2014 Aug; 2(8):789-99. PMID: 24801835. PMCID: PMC4396632.

d)  Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, Xiang X, Deng ZB, Wang B, Zhang L, Roth M, Welti R, Mobley J, Jun Y, Miller D, Zhang HG. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis.  Molecular Therapy 2013 Jul;21(7):1345-57. PMID: 23752315. PMCID: PMC3702113

e)  Zhuang X, Teng Y, Samykutty A, Mu J, Deng Z, Zhang L, Cao P, Rong Y, Yan J, Miller D, Zhang HG.  Grapefruit-derived nanovectors delivering therapeutic miR17 through an Intranasal route inhibit brain tumor progression.  Molecular Therapy 2016 Feb;24(1):96-105. doi: 10.1038/mt.2015.188. [Epub 2015 Oct 7] PMID: 26444082. PMCID: PMC4754550.

f)  Teng Y, Mu J, Hu X, Samykutty A, Zhuang X, Deng Z, Zhang L, Cao P, Yan J, Miller D, Zhang HG. Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.  Oncotarget 2016 May 3;7(18):25683-97. doi: 10.18632/oncotarget.8361. [Epub 2016 Mar 25] PMID: 27028860. PMCID:  PMC5041936.

g)  Xiang X, DengZ, Zhuang X, Ju S, Mu J, Jiang H, Zhang L, Yan J, Miller D, Zhang HG.  Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression.  PLoS One 2012­­­­­­­­­­­­­;7(12):e50781. PMID: 23284647. PMCID: PMC3524252.

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