Yun Teng, Ph.D., M.B.

Education:Yun Teng, Ph.D., M.B.

M.B., Huazhong University of Science and Technology, Tongji Medical College, Wuhan, Hubei, China; 1991
M.S., Huazhong University of Science and Technology, Tongji Medical College, Wuhan, Hubei, China; 1998
Ph.D., Huazhong University of Science and Technology, Tongji Medical College, Wuhan, Hubei, China; 2004
Postdoctoral Fellowship, James Graham Brown Cancer Center, University of Louisville, KY, USA; 2014

Curriculum Vitae

Current Positions:

Assistant Professor, Department of Medicine, School of Medicine, University of Louisville, KY, USA

Contact Information:

Clinical Translational Research Building, Room 312,
University of Louisville,
505 Hancock St.
Louisville, KY 40202, USA
Phone 502-852-6311
Fax 502-852-2123
Email: yun.teng@louisville.edu

Research Description:

My research interest is the development of edible plants exosomes-like nanoparticles (ELNs) based technology to treat cancer and inflammatory related diseases. In addition, I also work on understanding the cross-talking between edible plants-derived ELNs, gut microbiota and host immune cells in tumorigenesis, metastasis as well as autoimmune diseases. Edible plants affect anatomical niches of gut bacteria that regulate intestinal physiology. However, how edible plants modulate the biology of gut bacteria link to impact of host’s immune cells remain to be determined. In particular, I’m investigating the effect of ginger-derived ELNs miRNAs and lipids on macrophage and NKT cells, thus benefit the treatment of cancer and pathogen in liver and intestine.

Representative Publications (55 Max.):

  1.  Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, Hutchins E,  Mu J, Deng ZB, Luo C, Sundaram K, Sriwastva MK, Zhang L, Hsieh M, Redman R, Bodduluri H, Jun J, Jala VR, Miller DM,  Van Keuren-Jensen K, Merchant ML, McClain CJ, Park JW, Egilmez NK, Zhang HG.  Plant-derived exosomal microRNAs shape the gut microbiota.  Cell Host & Microbe in press,2018. (Co-senior author)
  2. Wang Q, Zhuang X, Sriwastva M, Mu J, Teng Y, Deng Z, Zhang L, Sundaram K, Kumar A, Miller D, Yan J, Zhang HG.  Blood exosomes regulate the tissue distribution of foreign nanoparticles via the CD36 and IGFR1 pathways.  Nanotheranostics in press 2018.
  3. Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG.  MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.  Nature Communications 2017 Feb 17;8:14448. (Co-senior author) PMID: 28211508.  PMCID: PMC5321731.
  4. Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M, Samykutty A, Zhang L, Yan J, Miller D, Suttles J, Zhang HG.  Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.  Molecular Therapy 2017 Jul 5;25(7):1641-54.  PMID: 28274798.  PMCID: PMC5498816.
  5. Teng Y, Mu J, Hu X, Samykutty A, Zhuang X, Deng Z, Zhang L, Cao P, Yan J, Miller D, Zhang HG.  Grapefruit-derived nanovectors deliver miR18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.  Oncotarget 2016 May 3;7(18):25683-97.  PMID: 2708860.  PMCID: PMC5041936.
  6. Deng Z, Rong Y, Teng Y, Zhuang X, Samykutty A, Mu J, Zhang L, Cao P, Yan J, Miller D, Zhang HG.  Exosomes miR-126a released from MDSCs induced by DOX treatment promotes lung metastasis.  Oncogene 2017 Feb 2;36(5):639-51.  PMID: 27345402.  PMCID: PMC5419051.
  7. Zhang HG, Cao P, Teng Y, Hu X, Wang Q, Yeri AS, Zhuang X, Samykutty A, Mu J, Deng ZB, Zhang L, Mobley JA, Yan J, Van Keuren-Jensen K, Miller D.  Isolation, identification, and characterization of novel nanovesicles.  Oncotarget 2016 Jul 5;7(27):41346-62.  PMID: 27191656.  PMCID: PMC5173064.
  8. Zhuang X, Teng Y, Samykutty A, Mu J, Deng Z, Zhang L, Cao P, Rong Y, Yan J, Miller D, Zhang HG.  Grapefruit-derived nanovectors delivering therapeutic miR17 through an intranasal route inhibit brain tumor progression.  Molecular Therapy 2016 Feb;24(1):96-105.  PMID: 26444082.  PMCID: PMC4754550.
  9. Teng Y, Radde BN, Litchfield LM, Ivanova MM, Prough RA, Clark BJ, Doll MA, Hein DW, Klinge CM.  Dehydroepiandrosterone qctivation of G-protein-coupled estrogen receptor rapidly wtimulates microRNA-21 transcription in human hepatocellular carcinoma cells.  Journal of Biological Chemistry 2015 Jun 19;290(25):15799-811.  PMID: 25969534.  PMCID: PMC4505488.
  10. Teng Y, Litchfield LM, Ivanova MM, Prough RA, Clark BJ, Klinge CM.  Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor.  Molecular & Cellular Endocrinology 2014 Jul 5;392(1-2):23-36.  PMID: 24845419.  PMCID: PMC4074919.
  11. Medjakovic S, Zoechling A, Gerster P, Ivanova MM, Teng Y, Klinge CM. Schildberger B, Gartner M, Jungbauer A.  Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor.  Environmental Toxicology 2014 Oct;29(10):1201-16.  PMID: 23436777.
  12. Manavalan TT, Teng Y (co-first author), Litchfield LM, Muluhngwi P, Al-Rayyan N, Klinge CM.  Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells.  PLoS One 2013 Apr 23;8(4): e62334.  PMID: 23626803.  PMCID: PMC3633860.
  13. Teng Y, Manavalan TT, Hu C, Medjakovic S, Jungbauer A, Klinge CM.  Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.  Toxicological Sciences 2013 Jan;131(1):71-83.  PMID: 23052036.  PMCID: PMC3537134.
  14. Manavalan TT, Teng Y, Appana SN, Datta S, Kalbfleisch TS, Li Y, Klinge CM.  Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.  Cancer Letters 2011 Dec 26;313(1):26-43.  PMID: 21954614.  PMCID: PMC3214732.
  15. Klinge CM, Radde BN, Imbert-Fernandez Y, Teng Y, Ivanova MM, Abner SM, Martin AL.  Targeting the Intracellular MUC1 C-terminal domain inhibits proliferation and estrogen receptor transcriptional activity in lung adenocarcinoma cells.  Molecular Cancer Therapeutics 2011 Nov;10(11):2062-71.  PMID: 21862684.  PMCID:  PMC3213286.
  16. Imbert-Fernandez Y, Radde BN, Teng Y, Young WW Jr, Hu C, Klinge CM.  MUC1/A and MUC1/B splice variants differentially regulate inflammatory cytokine expression.  Experimental Eye Research 2011 Nov;93(5):649-57.   PMCID: PMC3221811.
  17. Reyes-Reyes EM, Teng Y, Bates PJ.  A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism.  Cancer Research 2010 Nov 1;70(21):8617-29.  PMID: 20861190.  PMCID: PMC2970734.
  18. Teng Y, Girvan AC, Casson LK, Pierce WM Jr, Qian M, Thomas SD, Bates PJ.  AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin.  Cancer Research 2007; 67(21):10491-500.  PMID: 17974993.  [ http://cancerres.aacrjournals.org/content/67/21/10491.long ]
  19. Girvan AC, Teng Y, Casson LK, Thomas SD, Juliger S, Ball MW, Klein JB, Pierce WM Jr, Barve SS, Bates PJ.  AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.  Molecular Cancer Therapeutics 2006 Jul;5(7):1790-9.  PMID: 16891465.  [ http://mct.aacrjournals.org/content/5/7/1790.long ]

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