Joongho Joh, Ph.D.

Education:

B.S., Biochemistry, Konkuk University, Republic of (South) Korea, 1998
M.S., Biochemistry and Genetics, Konkuk University, Republic of (South) Korea, 2000
Ph.D., Molecular Biochemistry and Microbiology, Konkuk University, Republic of (South) Korea, 2005
Postdoctoral Fellowship,  Cancer Virology and Vaccinology, James Graham Brown Cancer Center, University of Louisville, KY, 2010

Curriculum Vitae

Current Positions:

Assistant Profressor, Department of Medicine, University of Louisville School of Medicine
Member, James Graham Brown Cancer Center

Contact Information:

Clinical Translational Research Building, Room 242A
University of Louisville
505 Hancock St.
Louisville, KY 40202, USA
Phone 502-852-1114
Fax 502-852-7979
Email: joongho.joh@louisville.edu

Research Description:

Dr. Joh has been working on developing cancer therapy for human papillomavirus (HPV)-induced cancers, which make up 5% of all solid tissue cancers, in collaboration with Drs. Alfred B. Jenson and Shinje Ghim who are co-inventors of HPV prophylactic vaccine (Cervical cancer vaccine). Although HPV prophylactic vaccines (Gardasil and Cervarix) are highly successful, development of a therapeutic vaccine or targeted treatment of 5% of cancers caused by HPV has never been successful.

Dr. Joh has recently developed an animal model (MmuPV1) for the HPV cancers, in which T lymphocyte-mediated tumor regression undergoes. Notably, he takes advantage of studying tumor specific antigens on benign and malignant tumors in order to identify the therapeutic targets of antitumor T cell immunity. His study will fill a gap of knowledge in the papillomavirus field to develop an effective therapeutic vaccine for HPV cancer patients.

Literature Cited:

  1. Sundberg JP, Stearns TM, Joh J, Proctor M, Ingle A, Silva KA, Dadras SS, Jenson AB, Ghim SJ. Immune status, strain background, and anatomic site of innoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas. PLoS ONE 9(12): e113582. doi:10.1371/journal.pone.0113582
  2. Ghim SJ, Joh J, Giannoni AA, Guzmán AL, Matos L, Guerrero MM, Villanueva M, Jenson AB, Bossart GD. Genital Papillomatosis Associated with Two Novel Mucosotropic Papillomaviruses from a Florida manatee (Trichechus manatus latirostris). Aquatic Mammals 2014, 40:195-200.
  3. Joh J, Proctor ML, Ditslear JL, King WW, Sundberg JP, Jenson AB, Ghim S. Epidemiological and phylogenetic analysis of institutional mouse parvoviruses. Exp Mol Pathol. 2013, 95(1):32-37. PMID: 23545399
  4. Storey R, Joh J, Jenson AB, Ghim S, Kloecker GH. Detection of Immunoglobulin G against E7 of Human Papillomavirus in non-small cell lung cancer. J Oncol 2013, 2013:240164. PMID: 23533408, PMCID: PMC3603668
  5. Joh J, Park Y, Son E, Yoon D, Kwon O, Han W, Nam J, Lee C. Isolation and characterization of differentially expressed genes in the mycelium and fruit body of Pleurotus ostreatus. African J Biotech 2013, 12:3790-6.
  6. Joh J, Jenson AB, Proctor ML, Ingle A, Silva KA, Potter CS, Sundberg JP, Ghim S. Molecular diagnosis of a laboratory mouse papillomavirus (MusPV). Exp Mol Pathol. 2012, 93(3):416-21. PMID: 22796029
  7. Joh J, Jenson AB, King WW, Proctor ML, Ingle A, Sundberg JP, Ghim S. Genomic analysis of the first laboratory-mouse papillomavirus.  J Gen Virol 2011, 92(3):692-698. PMID: 21084500
  8. Ingle A, Ghim S, Joh J, Chepkoech I, Jenson AB, Sundberg JP. Novel Laboratory Mouse Papillomavirus (MusPV) Infection. Vet Pathol 2011, 48(2):500-505. PMID: 20685915
  9. Joh J, Jenson AB, Moore GD, Rezazedeh A, Slone SP, Ghim S, Kloecker GH.Human Papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in Non Small Cell Lung Cancer. Exp Mol Pathol 2010, 89(3):222-226. PMID: 20699096
  10. Lee S*, Joh J*, Lee J, Yoo Y, Lee C, Kim B (*equal contribution). Isolation of genes specifically expressed in different developemental stages of Pleurotus ostreatus using macroarray analysis. Mycobiology 2009, 37(3): 230-237. PMID: 23983539, PMCID: PMC3749394
  11. Joh J, Hopper K,Doorslaer KV, Sundberg JP, Jenson AB, Ghim S. The Macaca fascicularis papillomavirus type 1 (MfPV-1): a nonhuman primate betapapillomavirus causing rapidly progressive hand and foot papillomatosis. J Gen Virol 2009, 90:987-994. PMID: 19264664
  12. Joh J, Kim K, Lim J, Son E, Park H, Park Y, Youn W, Kong W, Yoo Y, Lee C. Comparative Analysis of Expressed Sequence Tags from Flammulina velutipes at Different Developmental Stages. J Microbiol Biotechnol 2009, 19(8), 774-780. PMID: 19734714
  13. Cho Y, Weon H, Joh J, Lim J, Kim K, Son E, Lee C, Cho B. Effect of casing layer on growth promotion of the edible mushroom Pleurotus ostreatus. Mycobiology 2008, 36(1): 40-44. PMID: 23997606, PMCID: PMC3755250
  14. Joh J, Lee S, Lee J, Kim K, Jeong S, Youn W, Kim N, Son E, Cho Y, Yoo Y, Lee C, Kim B. Isolation of genes expressed during the developmental stages of the oyster mushroom, Pleurotus ostreatus, using expressed sequence tags. FEMS Microbiol Lett 2007, 276(1):19-25. PMID: 17937661
  15. Kim N, Joh J, Park H, Kim O, Park B, Lee C. Differential expression profiling of the proteomes and their mRNAs in porcine white and red skeletal muscles. Proteomics 2004, 4(11):3422-3428. PMID: 15449374

PubMed Information