Haixun Guo, Ph.D.

Education:Haixun Guo, Ph.D.

B.S., Applied Chemistry, Beijing Normal University, Beijing, China; 2002
Ph.D., Radiopharmaceutical Chemistry, Beijing Normal University, Beijing, China; 2007
Postdoctoral Fellowship, University of New Mexico, Albuquerque, NM; 2011

Curriculum Vitae

Current Positions:

Assistant Professor, Department of  Radiology

Contact Information:

Clinical Translational Research Building, Room 620
University of Louisville
505 Hancock St.
Louisville, KY 40202, USA
Phone 502-852-5577
Fax 502-852-5468
Email: Haixun.guo@louisville.edu

Research Description:

Guo’s lab focuses on the development of novel non-invasive PET (positron emission tomography) imaging biomarkers for early diagnosis and management of cancer and infection.

Representative Publications:

Molecular imaging agents for melanoma (MC1R)

Guo H, Yang J, Shenoy N, Miao Y.  Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging.  Bioconjugate Chemistry 2009 Dec;20(12):2356-63. PMID: 19919057. PMCID: PMC3009454.

Guo H, Gallazzi F, Miao Y.  Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake.  Bioconjugate Chemistry 2012 Jun 20;23(6):1314-48. PMID: 22621181. PMCID: PMC3440555.

Guo H, Yang J, Gallazzi F, Miao Y.  Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide resulting in enhanced melanoma uptake.  Journal of Nuclear Medicine 2010 Mar;51(3):418-26. PMID: 20150256. PMCID: PMC2998183.

Guo H, and Miao Y.  Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized α-MSH peptide in melanoma.  Journal of Nuclear Medicine 2014 Dec;55(12):2057-63. PMID: 25453052. PMCID: PMC4545635.

Structure optimization of peptide imaging agent

Guo H, Yang J, Gallazzi F, Prossnitz ER, Sklar LA, Miao Y.  Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide.  Bioconjugate Chemistry 2009 Nov;20(11):2162-8. PMID: 19817405. PMCID: PMC2786309.

Guo H, Yang J, Gallazzi F, Miao Y.  Effects of the amino acid linkers on the melanoma-targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized α-MSH peptides.  Journal of Nuclear Medicine 2011 Apr;52(4):608-16. PMID: 21421725. PMCID: PMC3065533.

Guo H, Miao Y.  Cu-64-labeled lactam bridge-cyclized α-MSH peptides for PET imaging of melanoma.  Molecular Pharmaceutics 2012 Aug 6;9(8):2322-30. PMID: 22780870. PMCID: PMC3480965.

Guo H, Miao Y.  Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized α-MSH peptide in melanoma.  Journal of Nuclear Medicine 2014 Dec;55(12):2057-63. PMID: 25453052. PMCID: PMC4545645.

GnRHR-targeting imaging agent

Guo H, Lu J, Hathaway H, Royce ME, Prossnitz ER, Miao Y.  Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides.  Bioconjugate Chemistry 2011 Aug 17;22(8):1682-9. PMID: 21749045. PMCID: PMC3157568.

Guo H, Gallazzi F, Sklar LA, Miao Y.  A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging.  Bioorganic & Medicinal Chemistry Letters 2011 Sep 15;21(18):5184-7. PMID: 21821417. PMCID: PMC3159814.

Guo H, Hathaway H, Royce ME, Prossnitz ER, Miao Y.  Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides.  Bioorganic & Medicinal Chemistry Letters 2013 Oct 15;23(20):5484-7. PMID: 24018188. PMCID: PMC3778074.

PubMed Information