Chin Ng, Ph.D.

Associate Professor

Department of Radiology


University of Louisville Hospital, 530 S. Jackson St. 502-852-5875 ckng0001@louisville.edu

Education

  • Ph.D., University of Wisconsin-Madison, WI
  • M.S., University of Wisconsin-Madison, WI
  • B.S.,  Purdue University, Fort Wayne, IN

Postgraduate Training

  • University of California-Los Angeles, CA, Nuclear Medicine and Biophysics, 1989-1991

Specialty Interests:

  • Medical Physics, Preclinical Imaging, Molecular Imaging

Research Interests:

  • Validating and characterizing novel imaging probes for multimodality imaging (MRI, PET, SPECT, CT and Optical)
  • Exploring approaches for early detection and monitoring of treatment efficacy of multiple diseases such as infectious diseases, cancer, spinal cord injury, brain diseases, diabetes and heart diseases.
  • Developing thermal laser ablation devices for treating spinal metastases in a MRI environment.

Selected Publications:

  • Li J, Bates PJ, Trent JO, Ng CK. Labeling G-rich oligonucleotides (GROs) with N-succinimidyl 4-[18- F]fluorobenzoate (S18FB).  J Label Compd Radiopharm 2006; 49:1213-1221.
  • Li J, Trent JO, Bates PJ, Ng CK. Factors affecting the labeling yield of F-18-labeled AS1411. J Label Compd Radiopharm 2007; 50(14):1255-1259.
  • Li Y, Woodall C, Wo JM, Zheng H, Ng CK, Ray MB, Martin RC. The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma. Cancer Investigation.  2008; 26:278-285.
  • Hougland, MT, Gao Y, Herman L, Ng CK, Lei Z, El-Mallakh. Positron emission tomography with fluorodeoxyglucose-F18 in an animal model of mania. Psychiatry Research: Neuroimaging. 2008; 164:166-171.
  • Wang Yi-Xiang J, Ng CK. The impact of quantitative imaging in medicine and surgery: Charting our course for the future.  Quant Imaging Med Surg 2011: 1(1): 1-3.
  • Li J, Gray BD, Pak KY, Ng CK. Radiolabeling and optimizing of zinc(II) dipicolylamine (DPA) with three 18F- prosthetic groups (18F-NFP, 18F-SFB and 18F-FET) as potential imaging agent for metastatic infectious disease. Journal of Labelled Compounds and Radiopharmaceuticals, March 14, 2012.
  • Huang T, Civelek AC, Li J, Jiang H, Ng CK, Postel GC, Shen B, Li XF. Tumor microenvironment-dependent 18F- FDG, 18F-fluorothymidine, and 18F-misonidazole uptake: A pilot study in mouse models of human non-small cell lung cancer. J Nucl Med 53(8):1262-1268, 2012.
  • Jonsson CB, Camp JV, Wu A, Zheng H, Kraenzle JL, Biller AE, Vanover CD, Chu YK, Ng CK, Proctor M, Sherwood L, Steffen MC, Mollura DJ. Molecular imaging reveals a progressive pulmonary inflammation in lower airways in ferrets infected with 2009 H1N1 pandemic influenza virus. PLoS ONE 7(7):1-12, July 2012.
  • Wu A, Zheng H, Krazenzler J, Biller A, Vanover C, Proctor M, Sherwood L, Steffen M, Ng C, Mollular DJ, Jonsson CB. Thoracic Anatomy by 18F-FDG PET/CT Imaging. Journal of Laboratory Animal Research, 2012 (published online: Issue of Neurobiology of Addictive Behaviors).
  • Huang T, Civelek AC, Zheng H, Ng CK, Duan X, Li J, Postel GC, Shen B, Li X. 18F-misonidazole PET imaging of hypoxia in micrometastases and macroscopic xenografts of human non-small cell lung cancer: a correlation with autoradiography and histological findings. Am J Nucl Med Mol Imaging 3(2):142-153, 2013.
  • Downs RK, Bashir MH, Ng CK, Heidenreich JO. Quantitative contrast ratio comparison between T1 (TSE at 1.5T, FLAIR at 3T), magnetization prepared rapid gradient echo and subtraction imaging at 1.5T and 3T. Quant Imaging Med Surg. 3(3): 141-146.
  • LeBlanc AJ, Nguygen QT, Touroo JS, Aird AL, Chang RC, Ng CK, Hoying JB, Williams SK. Adipose-derived cell construct stabilizes heart function and increases microvascular perfusion in an established infarct. Stem Cells Translational Medicine. 2(11):896-905, 2013.
  • Li XF, Huang T, Jiang H, Wang XM, Ng C, Wang XC, Postel G, Civelek AG and Shen BZ. Combined injection of 18F-fluorodeoxyglucose and 18F-fluorothymidine PET achieves more complete identification of viable lung cancer cells in mice and patients than each of the individual radiopharmaceutical injections: A proof-of-concept study. Translational Oncology 6(6):775-83, 2013.
  • Li J, Zheng H, Bates PJ, Malik T, Li XF, Trent JO, Ng CK. Aptamer imaging with Cu-64 labeled AS1411: Preliminary assessment in lung cancer. Nuc Med & Biology. 41(2):179-185, 2014.
  • Zhang Z, Winston GP, Zhao HT, Oei EHG, Ai Q, Loffroy R, Lin T, Shen Y, Ng CK, Liu H, Civelek AC, Han Z, He YM, Ji LY, Wang YXJ. Focus on China: Should clinicians engage in research? and lessons from other countries. Quant Imaging Med Surg 4(5): 413-425, 2014.
  • Wang YXJ, Loffroy R, Arora R, Suzuki K, Lee CH, Chung HW, Oei EHG, Winston GP, Ng CK. Relative income of clinical faculty members vs. science faculty members in university settings-a short survey of France, Hong Kong, India, Japan, South Korea, The Netherlands, Taiwan, UK, and USA. Quant Imaging Med Surg 4(6): 500-501, 2014.
  • Li J, Gerlach RL, Jonsson CB, Gray BD, Koon YP, Ng CK. Characterization of 18F-dipicolylamine (DPA) derivatives in cells infected with influenza virus. Nuclear Medicine and Biology. Nuclear medicine and biology. 42(3):283-291, 2015.
  • Morris ME, Beare JE, Reed RM; Dale JR, LeBlanc AJ, Kaufman CL, Zheng H, Ng CK, Williams SK, Hoying JB. Systemically-delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b(+)-cell-dependent mechanism. Stem Cells Trans Med 2015; 4:369-380.
  • Malik MT, O’Toole MG, Casson LK, Thomas SD, Bardi GT, Reyes-Reyes EM, Ng CK, Kang KA, Bates PJ. AS1411- conjugated gold nanospheres and their potential for breast cancer therapy. Oncotarget June 3, 2015.
  • Gossman M, Graham J, Depot S, Zheng HY, Li J, Ng CK, Tamez D. In vitro PET imaging of a miniature ventricular assist device. J Nucl Med Technol 2016; 44(3):190-194.
  • Yu JJ, Spieler BM, Chan TL, Johnson EM, Gulani V, Sandler KL, Narayana PA, Mar WA, Brian JM, Ng CK, Hardy PA. Promoting collaborations between radiologists and scientists. Acad Radiol. 2018 Jan;25(1):9-17.
  • Gossman MS, Zheng H, Evans JG, Li J, Ng CK. Assessment of radiopharmaceutical retention for vascular access ports using positron emission tomography imaging. J Appl Clin Med Phys. 2017 Nov;18(6):244-249.
  • Zhu M, Sun Z, Ng CK. Image-guided thermal ablation with MR-based thermometry. Quant Imaging Med Surg. 2017 Jun;7(3):356-368.
  • Gossman MS, Zhu M, Zheng H, Ng CK. Investigation of MRI contrast release from vascular access ports after priming. Insights Biomed Res. 2017, 1(1):12-16.
  • Gossman MS, Zheng H, Li J, Ng CK. A study of nuclear medicine contrast retention in vascular access ports. Insights Biomed Res. 2017, 1(1):17-22.
  • Zeng X, Li J, Ng CK, Hammond G, Xu B. (Radio)Fluoro-click reaction enabled by a hydrogen bonding cluster. Angew Chem Int Ed Engl. 2017 Dec 25.
  • Li J, Zheng H, Fodah R, Warawa JM, Ng CK. Validation of 2-18F-Fluorodeoxysorbitol as a potential radiopharmaceutical for imaging bacterial infection in the lung. J Nucl Med. 2018 Jan;59(1):134-139. (featured article of the month).