Haixun Guo, Ph.D.

Assistant Professor

Department of Radiology


haixun.guo@louisville.edu

Education:

Beijing Normal University, Ph.D.

Beijing, China, 2002-2007

Postgraduate training:

University of New Mexico, Postdoctoral fellow, Peptide Radiochemistry and Molecular Imaging

Albuquerque, NM, 2007-2011

Research Interests:

Development of PET/SPECT probes for imaging of infection, inflammation and cancer.

Publications:

  1. Yubin Miao, Fabio Gallazzi, Haixun Guo, Thomas P.Quinn. (2008) 111In-labeled lactam bridge-cyclized α-melanocyte stimulating hormone peptide analogues for melanoma imaging, Bioconjugate Chemistry; 19(2): 539-47.
  2. Haixun Guo, Nalini Shenoy, Benjamin M, Gershman, Jianquan Yang, Larry A. Sklar, Yubin Miao. (2009). Metastatic melanoma imaging with an 111In-labeled lactam bridge-cyclized α-melanocyte-stimulating hormone peptide, Nuclear Medicine and Biology, 36(3): 267-76. PMID: 19324272
  3. Haixun Guo, Jianquan Yang, Fabio Gallazzi, Eric R. Prossnitz, Larry A. Sklar, Yubin Miao. (2009). Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjugate Chemistry, 20(11):2162-2168. PIMD: 19817405
  4. Haixun Guo, Jianquan Yang, Nalini Shenoy, Yubin Miao. (2009). Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging. Bioconjugate Chemistry, 20(12):2356-2363. PMID: 19919057
  5. Jianquan Yang, Haixun Guo, Fabio Gallazzi, Marianne Berwick, R. Steven Padilla and Yubin Miao. (2009). Evaluation of a Novel Arg-Gly-Asp-conjugated α-Melanocyte Stimulating Hormone Hybrid Peptide for Potential Melanoma Therapy, Bioconjugate Chemistry; 20(8): 1634-42.
  6. Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. (2010) Reduction of the Ring Size of Radiolabeled Lactam Bridge-Cyclized Alpha-MSH Peptide Resulting in Enhanced Melanoma Uptake. Journal of Nuclear Medicine, 51:418-426. PMID: 20150256
  7. Jianquan Yang, Haixun Guo, Yubin Miao. (2010). Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nuclear Medicine and Biology, 37:873-883. PMID: 21055617
  8. Jianquan Yang, Haixun Guo, R. Steven Padilla, Marianne Berwick, Yubin Miao. (2010) Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide. Bioorganic & Medicinal Chemistry; 18:6695-6700.
  9. Haixun Guo, Jie Lu, Helen Hathaway, Melanie E. Royce, Eric R. Prossnitz, and Yubin Miao. (2011). Synthesis and Evaluation of Novel Gonadotropin-Releasing Hormone Receptor-Targeting Peptides. Bioconjugate Chemitry, 22:1682-1689. PMID: 21749045

10.  Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. (2011). Effects of the Amino Acid Linkers on the Melanoma-Targeting and Pharmacokinetic Properties of 111In-Labeled Lactam Bridge-Cyclized α-MSH Peptides. Journal of Nuclear Medicine, 52: 608-616. PMID: 21421725

11.  Haixun Guo, Fabio Gallazzi, Larry A. Sklar, and Yubin Miao. (2011). A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging. Bioorganic & Medicinal Chemistry Letters, 21:5184-5187. PMID: 21821417

12.  Haixun Guo, Fabio Gallazzi, and Yubin Miao. (2012). Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake. Bioconjugate Chemistry, Bioconjugate Chemistry, 23: 1314-1348. PMID: 22621181

13.  Haixun Guo, and Yubin Miao. (2012). Cu-64-Labeled Lactam Bridge-Cyclized α-MSH Peptides for PET Imaging of Melanoma. Molecular Pharmaceutics, 9: 2322-2330. PMID: 22780870

14.  Haixun Guo, and Yubin Miao. (2013). Design and Evaluation of New Tc-99m-Labeled Lactam Bridge-Cyclized Alpha-MSH Peptides for Melanoma Targeting. Molecular Pharmaceutics, 10:1400-8. PMID: 23418722

15.  Haixun Guo, and Yubin Miao. (2013). Melanoma targeting property of a Lu-177-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorganic & Medicinal Chemistry Letters, 23:2319-23. PMID: 23473679

16.  Haixun Guo, Helen Hathaway, Melanie E. Royce, Eric R. Prossnitz, and Yubin Miao. (2013). Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters, 23:5484-7. PMID: 24018188

17.  Baomei Wang, Xiaoying Zhuang, Zhong-Bin Deng, Hong Jiang, Jingyao Mu, Qilong Wang, Xiaoyu Xiang, Haixun Guo, Lifeng Zhang, Gerald Dryden, Jun Yan, Donald Miller, and Huang-Ge Zhang. (2013). Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Molecular Therapy, accepted Aug 2013. PMID: 23939022

18.  Haixun Guo, Yubin Miao. (2014). Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized α-MSH peptide in melanoma. Journal of Nuclear Medicine, 55: 2057-63. PMID: 25453052

19.  Schroeder CE, Yao T, Sotsky J, Smith RA, Roy S, Chu YK, Guo H, Tower NA, Noah JW, McKellip S, Sosa M, Rasmussen L, Smith LH, White EL, Aubé J, Jonsson CB, Chung D, Golden JE. (2014). Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. J Med Chem, 57(20):8608-21. PMID: 25244572

20.  Wang B, Zhuang X, Deng ZB, Jiang H, Mu J, Wang Q, Xiang X, Guo H, Zhang L, Dryden G, Yan J, Miller D, Zhang HG. (2014). Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther. 22(3):522-34. PMID: 23939022

21.  Zhongbin Deng, Jingyao Mu,     Michael Tseng, Binks Wattenberg, Xiaoying Zhuang, Nejat K. Egilmez, Qilong Wang, Lifeng Zhang, James Norris, Haixun Guo, Jun Yan, Bodduluri Haribabu, Donald Miller and Huang-Ge Zhang. (2015). Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. Nature Communications 6, article number: 6956. PMID: 25907800

22.  Jeremy V. Camp, Ulas Bagci, Yong-Kyu Chu, Brendan Squier, Mostafa Fraig, Silvia M. Uriarte, Haixun Guo, Daniel J. Mollura, and Colleen B. Jonsson. (2015). Lower Respiratory Tract Infection of the Ferret by 2009 H1N1 Pandemic Influenza A Virus Triggers Biphasic, Systemic, and Local Recruitment of Neutrophils. Journal of Virology 89 (17): 8733-8748. PMID: 26063430

23.  Matthew C. L. Keith, Yukichi Tokita, Xian-Liang Tang, Shahab Ghafghazi, Joseph B. MooreIV, Kyung U. Hong, Julius B. Elmore, Alok R. Amraotkar, Haixun Guo, Brian L. Ganzel, Kendra J. Grubb, Michael P. Flaherty, Bathri N. Vajravelu, Marcin Wysoczynski, Roberto Bolli. (2015). Effect of the stop-flow technique on cardiac retention of c-kit positive human cardiac stem cells after intracoronary infusion in a porcine model of chronic ischemic cardiomyopathy. Basic Research in Cardiology 110:46 PMID: 26150250.