Robert P. Friedland, M.D.
Mason C. and Mary D. Rudd Endowed Chair In Neurology
Professor, Dept. of Neurology
401 E. Chestnut Street, Suite 510, Louisville, KY 40292 • Clinical: 502-589-0802 • Academic: 502-852-7981
Dr Friedland is a clinical and research neurologist devoted to the study of brain disorders associated with aging. He is a graduate of the City College of New York and was a student at the University of Kentucky School of Medicine before graduating from the Mount Sinai School of Medicine in New York in 1973. He completed his neurology residency at the Mount Sinai Hospital and was a Fellow in dementia and aging at the Albert Einstein College of Medicine, NY. He then worked at the University of California, Davis, and in the Research Medicine Group of the Lawrence Berkeley Laboratory of the University California, Berkeley where he served as Chief Neurologist. From 1985 to 1990 he was Deputy Clinical Director and Chief of the Section on Brain Aging and Dementia of the National Institute on Aging, National Institutes of Health of Bethesda, MD. At the CWRU School of Medicine he was Professor of Neurology, Radiology and Psychiatry and Chief of the Laboratory of Neurogeriatrics from 1990 to 2008. In December of 2008 he joined the faculty of the University of Louisville, as a Professor of Neurology. Dr. Friedland’s work has focused on clinical and biological issues in Alzheimer’s disease and related disorders. Dr. Friedland has authored or coauthored over 200 scientific publications and has current research funding from the National Institutes of Health (National Institute on Aging), as well as several Foundations, Institutes, Corporations and Families. He has had over $1,000,000 of research funding to support his work from 1985-2013.
Education
City College of New York, New York
Degree: B.S., Biology
Mount Sinai School of Medicine
City University of New York
New York, New York
Degree: M.D.
Training
Straight Medicine Internship
Beth Israel Hospital
New York, New York
Neurology Residency and Chief Residency
Mount Sinai School of Medicine
New York, New York
Research Fellow, National Institutes of Health
(Senile Dementia: Biological and Behavioral Aspects)
Albert Einstein College of Medicine
New York, New York
Board Certifications
Certified, American Board of Psychiatry and Neurology
Clinical Interests
Dementia, Alzheimer’s disease, brain aging, prevention, neurogeriatrics, behavioral neurology
Research Interests
Dr. Friedland’s work has focused on clinical and biological issues in Alzheimer’s disease and related disorders. He was the first to document patterns of abnormal brain metabolism and cerebral blood flow in the disease using positron emission and single photon emission computed tomography. He also contributed the initial studies of magnetic resonance imaging in dementia. The first studies of driving behavior in patients with Alzheimer’s disease came from his group at the NIH. Dr. Friedland has also worked on the patterns of disease occurrence and risk and protective factors, with studies of the Kikuyu in Kenya, Jews and Arabs in Israel, Caucasian and African-American subjects in Ohio and Mexican and European American subjects in Texas. He has documented a series of important determinants of the disease, including physical and mental inactivity, smoking, obesity, and diet. This work has focused on interactions of genetic and environmental lifestyle elements. These studies have led to a National Health Literacy Program working to enhance public awareness about the disease and how lifestyle modifications may influence risk. His group also participated in the discovery of the important Alzheimer’s disease risk factor gene, SORL1. Animal models have been used by Dr Frieldand and his collaborators to better define the biological mechanisms of Alzheimer’s disease in order to develop new treatments. The first demonstration of catalytic antibodies targeting the Alzheimer amyloid Beta protein in the blood was published by his group in 2007. In 2008 Dr Friedland and colleagues reported the first demonstration of a possible interaction involving molecular mimicry between protective anti-amyloid antibodies and exposure to a plant virus. Current studies are devoted to developing immunological approaches to the treatment of both Alzheimer and Parkinson’s diseases.
Academic and Community Education Activities
1. On Sep 17, 2011 at the Crowne Plaza we hosted a meeting for the community called “The Journey: Alzheimer’s Disease and Caregiving”. The session was attended by about 120 persons, many of whom were family caregivers. The talks were well received by the audience and there were many questions asked during the Q&A session as well as during the lunch break. The links below are video recordings of the talks. We plan to continue to host such educational meetings regarding Alzheimer disease and other dementias for the community each year.
Alzheimer Meeting Sep 17th 2011 Agenda Download PDF (453KB)
- Opening Remarks (Suhas Kulkarni and Helen Lang): http://louisville.edu/television/Med/Alzheimers/OpeningRemarks1.asx
- Dr Obisesan: http://louisville.edu/television/Med/Alzheimers/Obiesesan1.asx
- Dr Robert Friedland: http://louisville.edu/television/Med/Alzheimers/Friedland1.asx
- Dr. Karen Robinson: http://louisville.edu/television/Med/Alzheimers/Robinson1.asx
- Dr Dee Antimisiaris: http://louisville.edu/television/Med/Alzheimers/Antimisiaris1.asx
- Dr David Casey: http://louisville.edu/television/Med/Alzheimers/Casey1.asx
- Johanna Weiss (Alzheimer Association, Louisville): http://louisville.edu/television/Med/Alzheimers/Weiss1.asx
- Q&A http://louisville.edu/television/Med/Alzheimers/QandA1.asx
- Panel Discussion: http://louisville.edu/television/Med/Alzheimers/Panel1.asx
Louisville Free Pubic Library series: Boom Time Series Jan 18, 2012
Dr. Robert Friedland. “Your brain: How to reduce your risk”
http://louisville.edu/television/Med/Alzheimers/Friedland.asx
Neurology Grand Rounds Mar 16, 2012
Dr. Robert Friedland. The Framing of the Concept of Dementia:
From Emil Kraepelin to National Institute of Aging
http://louisville.edu/television/Med/GrandRounds/NGR031612.asx
Selected Publications
216. Raha AA, Henderson JW, Stott SR, Vuono R, Foscarin S, Friedland RP, Zaman SH, Raha-Chowdhury R. Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model. J Alzheimers Dis. 2017;55(1):199-217. PubMed PMID: 27662313. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
215. Chen SG, Stribinskis V, Rane MJ, Demuth DR, Gozal E, Roberts AM, Jagadapillai R, Liu R, Choe K, Shivakumar B, Son F, Jin S, Kerber R, Adame A, Masliah E, Friedland RP. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Sci Rep. 2016 Oct 6;6:34477. doi: 10.1038/srep34477. PubMed PMID: 27708338; PubMed Central PMCID: PMC5052651. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
214. Roberts AM, Jagadapillai R, Vaishnav RA, Friedland RP, Drinovac R, Lin X, Gozal E. Increased pulmonary arteriolar tone associated with lung oxidative stress and nitric oxide in a mouse model of Alzheimer's disease. Physiol Rep. 2016 Sep;4(17). pii: e12953. doi: 10.14814/phy2.12953. PubMed PMID: 27604401. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
213. Watanabe I, Kuriyama N, Miyatani F, Nomura R, Naka S, Nakano K, Ihara M, Iwai K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Tamura A, Mizuno T, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Tanaka T, Kanamura N, Friedland RP, Watanabe Y. Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment. Sci Rep. 2016 Dec 9;6:38561. doi: 10.1038/srep38561. PubMed PMID: 27934941; PubMed Central PMCID: PMC5146923. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
212. Tonomura S, Ihara M, Kawano T,Tanaka T, Okuno Y, Saito S, Friedland RP, Kuriyama N, Nomura R, Watanabe Y, Nakano K, Toyoda K, Nagatsuka K. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study, Sci Rep. 2016 Feb 5;6:20074. doi:10.1038/srep20074. PubMed PMID: 26847666; PubMed Central PMCID: PMC4742798. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
211. Miyatani F, Kuriyama N, Watanabe I, Nomura R, Nakano K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Mizuno T, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Ihara M, Kanamur M, Friedland RP, Watanabe Y. Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans Oral Diseases 2015;21:886-93. doi: 10.1111/odi.12360. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
210. Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y, Mudher A, Padjen AL, Mukaetova-Ladinska E, Ihara M, Srivastava S, Padma Srivastava MV, Masters CL, Kalaria RN, Anand A Translation of pre-clinical studies into successful clinical trials for Alzheimer ’s disease: What are the roadblocks and how can they be overcome? Journal of Alzheimer’s Disease 2015 11;47:815-43. doi: 10.3233/JAD-150136. PubMed PMID: 26401762. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
209. Planque SA, Nishiyama Y, Sonoda S, Lin Y, Taguchi H, Hara M, Kolodziej S, Mitsuda Y, Gonzalez V, Sait HB, Fukuchi KI, Massey RJ, Friedland RP, O'Nuallain B, Sigurdsson EM, Paul S. Specific Amyloid β Clearance by a Catalytic Antibody Construct. Journal of Biological Chemistry 2015. pii: jbc.M115.641738. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
208. Werner P, Friedland R, Inzelberg R, Alzheimer's disease and the elderly in Israel: Are we paying enough attention to the topic in the Arab population? American Journal of Alzheimer's Disease and Other Dementias 2015. pii: 1533317515577130. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
207. Friedland RP, Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. Journal of Alzheimer’s Disease 2015;45:349-62 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
206. Inzelberg R, Massarwa M, Schechtman E, Strugatsky R, Farrer LA, Friedland RP. Estimating the risk for conversion from mild cognitive impairment to Alzheimer's disease in an elderly Arab community Journal of Alzheimer’s Diease 2015;45:865-71 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
205. Liu R, Vaishnav RA, Roberts AM, Friedland RP. Parkinson disease, edible Solanaceae, and tobacco mosaic virus. Ann Neurol. 2014 Jan;75(1):162-3. doi: 10.1002/ana.24041. PubMed PMID: 24523201. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
204. Furman CD, Earnshaw LA, Doukas DJ, Farrer LA, Friedland RP. A case of inappropriate Apolipoprotein E testing in Alzheimer's disease due to lack of an informed consent discussion. American Journal of Alzheimers Disease and Other Dementias 2014;29:590-5. PMID: 24615498. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
203. Fujioka H, Phelix CF, Friedland RP, Zhu X, Perry E, Castellani RJ, Perry G, Apolipoprotein E e4 prevents growth of malaria at the intraerythrocyte stage: Implications for differences in racial susceptibility to Alzheimer’s disease. Journal of Health Care for the Poor and Underserved 2013;24: 70–78. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
202. Raha AA, Vaishnav RA, Friedland RP, Bomford A, Raha-Chowdhury R, The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease. Acta Neuropathologica Communications (2013) 55. doi: 10.1186/2051-5960-1-55. PMID:24252754 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
201. Rebolledo-Mendez JD, Radhika A. VaishnavRA, Cooper NG, Friedland RP. Cross-kingdom sequence similarities between human micro-RNAs and plant viruses. Communicative and Integrative Biology, 2013;6:e24951. doi: 10.4161/cib.24951. PMID:24228136 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
200. Vaishnav RA, Liu R, Chapman J, Roberts AM, Ye H, Rebolledo-Mendez JD, Tabira T, Fitzpatrick AH, Achiron A, Running MP, Friedland RP, Aquaporin 4 Molecular Mimicry and Implications for Neuromyelitis Optica, Journal of Neuroimmunology, 2013;260(1-2):92-8. doi: 10.1016/j.jneuroim.2013.04.015. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
199. Liu R, Vaishnav R, Roberts A, Friedland RP (2013) Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus. PLoS ONE 8:e60621. doi:10.1371/journal.pone.0060621. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
198. Friedland RP, Nandi S, A Modest Proposal for a Longitudinal Study of Dementia Prevention (with apologies to Jonathan Swift, 1729) Journal of Alzheimer’s Disease, 2013;33:313-5. doi: 10.3233/JAD-2012-121459 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
197. Vardarajan BN, Bruesegem SY, Harbour ME, St George-Hyslop P, Seaman MN, Inzelberg R, Friedland RP, Farrer LA. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiology of Aging 2012:33:2231. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
196. Sabbagh MN, Messis C, Friedland RP, Geula C. The 5th International Conference on Alzheimer's Disease and related disorders in the Middle East, 15-17 May 2009, Limassol Cyprus. Journal of Alzheimer’s Disease. 2012;30:711-27. PubMed PMID: 22614876. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
195. Friedland RP, Shah JJ, Farrer LA, Vardarajan B, Rebolledo-Mendez JD, Mok B, Hardy J, Behavioral variant frontotemporal lobar degeneration with amyotrophic lateral sclerosis with a chromosome 9p21 hexanucleotide repeat. Frontiers in Neurogenomics 3:136, 2012, oi:10.3389/fneur.2012.00136 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
194. Rothenberg KG, Piądło R, Nagaraj UD, Veluvolu S, Friedland RP The Complex Picture Test in Dementia, Dementia and Geriatric Cognitive Disrders, Extra, 2:411-7, 2012. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
193. Inzelberg R, Afgin AE, Massarwa M, Schechtman E, Israeli-Korn SD, Strugatsky R, Abuful A, Kravitz E, Farrer LA, Friedland RP. Prayer at midlife is associated with reduced risk of cognitive decline in Arabic women. Current Alzheimer Research 2012:10:340-6.PMID: 23116476 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
192. Afgin AA, Massarwa M, Schechtman E, Israel-Korn SD, Strugatsky R, Abuful A, Farrer LA, Friedland RP, Inzelberg R. High Prevalence of Mild Cognitive Impairment and Alzheimer's Disease in Arabic Villages in Northern Israel: Impact of Gender and Education. Journal of Alzheimer’s Disease, 2012;29:431-9. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
191. Logue MW, Schu M, Vardarajan BN, Buros J, Green RC, Go RC, Griffith P, Obisesan TO, Shatz R, Borenstein A, Cupples LA, Lunetta KL, Fallin MD, Baldwin CT, Farrer LA; Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study Group (including Friedland RP). A comprehensive genetic association study of Alzheimer disease in African Americans. Arch Neurol. 2011;68:1569-79, PMCID: PMC3356921. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
190. Perneczky R, Wagenpfeil S, ....Friedland RP.....et al...(21 collaborators). MIRAGE Study Group. Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology. 2010;75:137-42. PMID: 20625166; PMCID: PMC2905931. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
189. Rimol LM, Agartz I, ....Friedland RP....(194 collaborators). Alzheimer's Disease Neuroimaging Initiative. Sex-dependent association of common variants of microcephaly genes with brain structure. Proceedings of the National Academy of Sciences USA 2010;107:384-8. Epub 2009 Dec 22. PubMed PMID: 20080800; PubMed Central PMCID: PMC2806758. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
188. Ho AJ, Stein JL, ....Friedland RP.... et al...(194 collaborators). Alzheimer's Disease Neuroimaging Initiative. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proceedings of theNational Academy of Sciences USA. 2010;107:8404-9. Epub 2010. PMID: 20404173; PMC2889537. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
187. Wolk DA, Dickerson BC.... Friedland RP et al....(194 collaborators). Alzheimer's Disease Neuroimaging Initiative. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proceedingss of the National Academy of Sciences USA. 2010;107:10256-61. Epub 2010 May 17. PMID: 20479234; PMC2890481. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
186. Logue MW, Posner H, Green RC, Moline M, Cupples LA, Lunetta KL, Zou H, Hurt SW, Farrer LA, Decarli C; MIRAGE Study Group (including Friedland RP). Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer's disease patients. Alzheimer’s Dementia. 2011;7:493-500; PubMed Central PMCID. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
185. Sherva R, Baldwin CT, Vardarajan B, Cupples A, Lunetta K, Bowirrat A, Inzelberg R, Friedland RP, Farrer LA Identification of Novel Candidate Genes for Alzheimer Disease by Autozygosity Mapping Using Genome Wide SNP Data From an Israeli-Arab Community, Journal of Alzheimer’s Disease, 2011, 23:349-59. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
184. Israeli-Korn SD, Massarwa M, Schechtman E, Strugatsky R, Avni S, Farrer LA, Friedland RP, Inzelberg R, Mild cognitive impairment is associated with mild parkinsonian signs in a door-to-door study of an elderly Arab population, Journal of Alzheimer’s Disease,22:1005-1013, 2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
183. Khatchaturian A, Khatchaturian Z, Inzelberg R, Farrer LA, Roses A, Sager M, Friedland RP US-Israel Demonstration Project for a Longitudinal Database for Healthy Aging and Pre-Clinical Dementia: A Perspective, Alzheimer’s Disease and Related Disorders 6:475-481, 2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
182. Perneczky R, Wagenpfeil S, Lunetta KL, Cupples LA, Green RC, Decarli C, Farrer LA, Kurz A; MIRAGE Study Group. Baldwin C, Logue MW, Auerbach S, Wake M, Akomolafe A, Ashley A, Freedman L, Ofili E, Chui H, Duara R, Foroud T, Farlow M, Friedland R, Lerner A, Go R, Obisesan T, Petrovich H, White L, Sabbagh M, Sadovnick D, Tsolaki M. Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology. 2010;75:137-42. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
181. Jun G, Naj AC, Beecham GW, Wang LS, Buros J, .......Friedland RP, ........et al... Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes. Archives of Neurology. 2010 Sep 3. [Epub ahead of print] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
180. Hunter S, Friedland RP, Brayne C Time for a Change in the Research Paradigm for Alzheimer's Disease: The Value of a Chaotic Matrix Modeling Approach. CNS Neuroscience Theraputics Epub ahead of print. CNS Neurosci Ther. 2010;16:254-62. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
179. Rexroth, DF, Friedland, RP Lessons learned regarding recruitment to the National African American Alzheimer’s Disease Health Literacy Program. Alzheimer’s Disease and Associated Disorders 17:86-90, 2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
178. Jack CR Jr, Lowe VJ, Weigand SD, Wiste HJ, .......Friedland RP, ........et al... (206 collaborators). Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain. 2009;132:1355-65. Epub 2009 Mar 31 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
177. Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL.......Friedland RP, ........et al... Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009;132:1310-23. Epub 2008 Nov 28. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
176. Geula C, Efthymiopoulos S, Friedland RP, Meeting Report: The 4th International Symposium on Alzheimer’s Disease and Related Disorders in the Middle East, October, 2007, Athens, Greece, Amyloid, 2010;17:86-90. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
175. Holland D, Brewer JB, Hagler DJ, Fenema-Notestine C, .......Friedland RP, ........et al.. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proceedings of the National Academy of Sciences U S A. 2009;106:20954-20959. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
174. Cuenco KT, Friedland R, Baldwin CT, Guo J, Vardarajan B, Lunetta KL, Cupples LA, Green RC, Decarli C, Farrer LA; for the MIRAGE Study Group.Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families. Neurobiology of Aging (2011) 32:249-56 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
173. Keage HA, Carare RO, Friedland RP, Ince PG, Love S, Nicoll JA, Wharton SB, Weller RO, Brayne C. Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review. BioMedCentral Neurology. 2009 Jan 13;9:3. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
172. Llewellyn DJ, Langa KM, Friedland RP, Lang IA. Serum albumin concentration and cognitive impairment. Current Alzheimer Research. 7:91-96,2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
171. Israeli-Korn SD, Masarwa M, Schechtman E, Abuful A, Strugatsky R, Avni S, Farrer LA, Friedland RP, Inzelberg R. Hypertension increases the probability of Alzheimer’s disease and of mild cognitive impairment in an Arab community in Northern Israel. Neuroepidemiology 2010;34:99-105. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
170. Hardwick A, Rucker, JC ,Cohen M L, Friedland, RP. Gustaw-Rothenberg K,; Riley, David E, Leigh RJ. Evolution of ocular motor and clinical findings in autopsy-proven Richardson’s syndrome. Neurology 2009, 15;73:2122-4. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
169. Friedland RP, Petersen RB, Rubenstein R. Bovine spongiform encephalopathy and aquaculture. Journal of Alzheimer’s Disease. 2009 Jun;17:277-9. Mar 6, 2009. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
168. Friedland RP, Brayne. What should the pediatrician know about Alzheimer’s disease? Journal of Developmental and Behavioral Pediatrics 30:239-41, 2009 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
167. Cuenco K, Friedland R, Baldwin C, Jianping G, Varadarajan B, Lunetta K, Cupples A, Green R, DeCarli C, Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families. Farrer L Neurobiology of Aging. 2011;32:249-56. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
166. Glik A, Masarwa M, Abuful A, Deeb A, Strugatsky R, Farrer LA, Friedland RP, Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages. Inzelberg R Movement Disorders. 2008. [Epub ahead of print]. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
165. Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA; MIRAGE Study Group(including RP Friedland) Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Archives of Neurology. 2008;65:1640-8. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
164. Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, Prince M, Stewart R, Wimo A, Zhang ZX, Antuono P; World Federation of Neurology Dementia Research Group. Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors Lancet Neurol. 2008 ;7:812-26. Epub 2008 Jul 28. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
163. Chen CH, Mizuno T, Elston R, Kariuki MM, Hall K, Unverzagt F, Hendrie H, Gatere S, Kioy P, Patel NB, Friedland RP, Kalaria RN. A comparative study to screen dementia and APOE genotypes in an ageing East African population. Neurobiol Aging. 31:732-740,2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
162. Friedland RP, Tedesco JM, Wilson AC, Atwood CS, Smith MA, Perry G, Zagorski G. Antibodies to the potato virus Y bind the Aβ peptide: Immunochemical and NMR studies. Journal of Biological Chemistry 283:22550-22556, 2008 (Epub 5/27/08). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
161. Gustaw KA,. Garrett MR , Lee H-G, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP,. Smith MA Antigen-Antibody Dissociation in Alzheimer Disease: A Novel Approach to Diagnosis. Journal of Neurochemistry 2008;106:1350-6. Epub 2008 May 12. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
160. Taguchi H, Planque S, Nishiyama Y, Szabo P, Weksler ME, Friedland RP, Sudhir S Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease Autoimmunity Reviews 7:391-7, 2008. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
159. Taguchi H, Planque S, Nishiyama Y, Symersky J, Boivin S, Szabo P, Friedland RP, Ramsland PA, Edmundson AB, Weksler ME, Paul S. Autoantibody catalyzed hydrolysis of amyloid beta peptide. Journal of Biological Chemistry 283:4714-22, 2008. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
158. Friedland RP, Emre M, Geula C. The Third International Symposium on Alzheimer’s Disease and Related Disorders in the Middle East, Istanbul, Turkey, October 1-2, 2005 Amyloid 14:161-168, 2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
157. Goodenowe DB, Cook LL, Liu J, Yingshen Lu,. Jayasinghe DA, Pearson W.K. Ahiahonu, Heath D, Yamazaki Y, Flax J, Krenitsky KF, Sparks DL, Lerner AL, Friedland RP, Kudo T, Kamino K, Morihara T, Takeda M, Wood PL. Peripheral ethanolamine plasmalogen deficiency: A logical causative factor in Alzheimer's disease and dementia. Journal of Lipid Research 48:2485-98,2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
156. Bonda DJ, Webber KM, Siedlak SL, Perry G, Friedland RP, Smith MA. The pathology of Alzheimer's disease elicits an in vivo immunological response. American Journal of Immunology 3: 10-14, 2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
155. Huang J, Friedland RP, Auchus AP, Diffusion tensor imaging of normal appearing white matter in MCI and early AD: Preliminary evidence of axonal degeneration in temporal lobe. American Journal of Neuroradiology 28:1943-48, 2007, | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
154. Friedland RP, Armon C, Editorial - Tales of Pacific tangles: Cycad exposure and Guamanian neurodegenerative diseases, Neurology 68:1759-761, 2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
153. Fritsch T, McClendon MJ, Smyth KA, Lerner AJ, Friedland, RP, Larsen J. Cognitive functioning in healthy aging: The role of reserve and lifestyle factors early in life. The Gerontologist 47:307-22,2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
152. Petot GJ, Vega U, Traore F, Fritsch T, Debanne SM, Friedland RP, Lerner AJ Height and Alzheimer’s disease: Findings from a case-control study. Journal of Alzheimer’s Disease 11:337–341, 2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
151. Rogaeva E, Meng Y, Leen JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland R, Inzelberg R, Hampe W, Bujo H, Song Y, Andersen O, Graff-Radford N, Petersen R, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer’s Disease. Nature Genetics 39:168-177, 2007. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
150. Green RC, McNagny SE, Jayakumar P, Cupples LA, Benke K, Farrer LA for the MIRAGE Study (including Friedland RP). Statin use and the risk of Alzheimer’s disease: The MIRAGE Study. Alzheimer’s & Dementia 2:96-103, 2006 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
149. Erlich PE, Lunetta KL, Cupples LA , Huyck M, Green RC, Baldwin CT, Farrer LA , and the MIRAGE Study Group (including RP Friedland) Polymorphisms in the PON gene cluster are associated with Alzheimer disease, Human Molecular Genetics 15:77-85, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
148. Akomolafe A, Lunetta KL, Erlich PM, Cupples LA, Baldwin CT, Huyck M, Green RC, Farrer LA and the MIRAGE Study Group (including Friedland RP). Genetic association between endothelial nitric oxide synthase and Alzheimer’s disease. Clinical Genetics 70:49-56, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
147. Kishikawa Y, Friedland RP, Socio-cultural background of suicide in Alzheimer’s disease – A cross cultural study of two Alzheimer’s disease patients in the United States and Japan. International Psychogeriatrics (in press). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
146. Inzelberg, R, Schechtman, E, Abuful, A, Masarwa, M, Mazarib A, Strugatsky R, Farrer LF, Friedland RP. Education effects on cognitive function in a healthy aged Arab population. International Psychogeriatrics 2006:1-11, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
145. Meng Y, Baldwin CT, Bowirrat A, Waraska K, Friedland RP, Farrer LA, Associations in the angiotensin-converting enzyme gene with Alzheimer’s disease in an Israeli-Arab community. American Journal of Human Genetics 78:871-877, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
144. Inzelberg, R, Mazarib A, Masarwa, M, Abuful A, Strugatsky R. Friedland, RP Essential tremor prevalence is low in Arabic villages in Israel -Door-to-door neurological examinations. Journal of Neurology 253:1557-1560, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
143. Sparks DL, Robert Friedland RP (The first 2 authors contributed equally as lead investigators), Petanceska S, Schreurs BG, Shi J, Perry G, Smith MA, Sharma A, DeRosa S, Ziolkowski C, Stankovic G. Trace copper levels in the drinking water, but not zinc or aluminum, influence CNS Alzheimer-like pathology. Journal of Nutrition, Health and Aging 10:247-254, 2006 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
142. Fritsch T, Smyth KA, Debanne SM, Petot G, Friedland RP. Participation in ”novelty seeking” leisure activities and Alzheimer’s disease. Journal of Geriatric Psychiatry and Neurology, 18:134-141, 2005. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
141. Lee JH, Friedland RP, Whitehouse PJ, Woo JI. Twenty-four hour rhythms of sleep wake cycle and temperature in Alzheimer’s disease. Journal of Neuropsychiatry and Clinical Neuroscience 16:192-198 2004. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
140. Lindstrom HA, Fritsch T, Petot G, Smyth KA, Chen CH, Debanne SM, Lerner AJ, Friedland RP, The relationships between television viewing in midlife and the development of Alzheimer disease in a case-control study, Brain and Cognition 58:157-165, 2005. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
139. Bowirrat A, Cui J, Waraska K, Friedland RP, Oscar-Berman M, Farrer LA, Korczyn A ,association between angiotensin-converting enzyme (ACE) and dementia of the Alzheimer’s type (DAT) in an elderly Arab population in Wadi Ara, Israel. Neuropsychiatric Disease and Treatment, 1:73-76, 2005. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
138. Geula C, Emre M, Friedland RP. The 2nd International Symposium on Alzheimer’s disease and Related Disorders in the Middle East, May 1-3, 2004, Istanbul, Turkey. Amyloid 11:276-280, 2004. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
137. Mizrahi EH, Bowirrat A, Jacobsen DW, Korczyn AD, Traore F, Petot GJ, Lerner AJ, Debanne SM, Adunsky A, DiBello PM, Friedland, RP. Plasma homocysteine, vitamin B12 and folate in Alzheimer’s patients and healthy Arabs in Israel. Journal of Neurological Sciences 15;227:109-13, 2004. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
136. Smyth KA, Fritsch T, Cook TB, McClendon MJ, Santillan CE, Friedland RP. Worker functions and traits associated with occupations and the development of Alzheimer’s disease. Neurology 63:498-503, 2004. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
135. Petot G, Friedland RP. Diet, lipids and Alzheimer’s disease. Journal of the Neurological Sciences 226:31-33, 2004. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
134. Castellani RJ, Smith MA, Perry G, Friedland RP. Cerebral amyloid angiopathy: Major contributor or decorative response to Alzheimer’s disease pathogenesis. Neurobiology of Aging;25(5):599-602; May-Jun 2004. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
133. Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer’s disease and Alzheimer-like pathology in transgenic mice. Neurological Research 25:655-674, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
132. Friedland RP. Editorial: Fish consumption and the risk of Alzheimer’s disease: Is it time to make dietary recommendations? Archives of Neurology, 60:923-924, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
131. Bowirrat A, Friedland RP, Korczyn AD, Vascular dementia among elderly Arabs in Wadi Ara, Journal of Neurological Sciences 203-204:73-76, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
130. Mizrahi EH, Jacobsen DW, Debanne SM, Traore F, Lerner AJ, Friedland RP, Petot GJ. Plasma total homocysteine levels, dietary B6 and folate intake in AD and healthy aging. Journal of Nutrition, Health and Aging 7:160-165, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
129. Farrer, LA, Bowirrat, A, Friedland RP, Waraska, K, Korczyn, AD, Baldwin, CT. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Human Molecular Genetics 12:415-422, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
128. Farrer, L.A., Friedland RP, Bowirrat A, Waraska, Korczyn AD, Baldwin CT. Genetic and environmental risk factors for Alzheimer’s disease in Israeli Arabs. Journal of Molecular Neuroscience 20:207-212, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
127. Petot G, Chen C, Traore F, Debanne S, Friedland RP, Interactions of apolipoprotein E genotype and dietary fat intake of healthy older persons during mid-adult life. Metabolism 52:279-281, 2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
126. Green RC, Cupples LA, Kurz A, Auerbach S, Go R, Sadovnick D, Duara R, DeCarli C, Kukull W, Chui H, Edeki T, Griffith P, Friedland RP, Bachman D, Farrer LA: Depression as a risk factor for Alzheimer’s disease: The MIRAGE study. Archives of Neurology 60:753-759,2003. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
125. Aliev G, Smith MA, Seyidova D, Neal ML, Shi J, Loizidou M, Turmaine M, Friedland RP, Taylor I, Burnstock G, Perry G, Lamanna JC. Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium. J Submicroscopic and Cytological Pathology 34:37-50, 2002 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
124. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Winters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences 977:45-64, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
123. Bowirrat A, Friedland RP, Farrer L, Baldwin C, Korczyn A. Genetic and environmental risk factors for Alzheimer’s disease in Israeli Arabs. Journal of Molecular Neuroscience 19: 239-245, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
122. Friedland RP, Lipid Metabolism, epidemiology and the mechanisms of Alzheimer’s disease. Annals of the New York Academy of Sciences 977:387-390, 2002 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
121. Aliev G, Smith MA, Perry G, Samedov S, Seyidova D, Friedland RP, La Manna JC, Gasimov EK. The experimental model of Alzheimer’s disease and its selective pharmacological treatments. Academy of Sciences of Azerbaijan Reports 57:112-118, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
120. Shi J, Perry G, Berridge MS, Aliev G, Siedlak SL, Smith MA, La Manna JC, Friedland RP. Labeling of cerebral Aβ deposits in vivo using intranasal bFGF and SAP component in mice, Journal of Nuclear Medicine 43:1044-1051, 2002. (Invited Commentary on this paper was published in the same issue: Potential for a sprecific neuroradiological diagnosis of Alzheimer’s disease, Blass JB, Journal of Nuclear Medicine 43:1051-1053, 2002). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
119. Friedland RP, Petot GJ, Farrer LF. Diet and Alzheimer’s disease. Arab Journal of Psychiatry 13:10-17 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
118. Mizrahi E, Jacobsen DW, Friedland RP. Plasma homocysteine: A new risk for Alzheimer’s disease? Israel Medical Association Journal 4:1-4,2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
117. Fritsch T, McLendon MJ, Smyth KA, Lerner AJ, Chen CH, Petot GJ, Debanne SM, Soas A, Friedland RP. Effects of educational attainment on the clinical expression of Alzheimer’s disease: Results from a research registry. American Journal of Alzheimer’s Disease and Other Dementias 16:369-376, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
116. Aliev G, Smith MA, Zimina TV, Neal ML, Lamb BT, Nunomura A, Seyidova D, Vinters HV, LaManna JC, Perry G, Friedland RP. The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer’s’ disease. Brain Pathology 12:21-35, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
115. Mizrahi E, Fritsch T, Smyth KA, Friedland RP, Lerner AJ. Medication use in Alzheimer’s Disease. Clinical Gerontologist 24:75-84, 2001 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
114. Debanne SM, Petot GJ, Li J, Koss E, Lerner AJ, Riedel TM, Rowland DY, Smyth KA, Friedland RP. On the use of surrogate respondents for controls in a case-control study of Alzheimer’s disease. Journal of the American Geriatrics Society 49:1-5,2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
113. Aliev, G, Seyidove, D, Neal, ML, Shi, J, Vigano, T, Hernandez, A, Folco, G., Soas, AH, Zimina, TV, Smith, MA, Perry, G, Lamanna, JC, Friedland, RP. The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro. Journal of Submicroscopic Cytology and Pathology 33:141-149, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
112. Friedland RP, Fritsch T, Smyth KA, Koss E, Lerner AJ, Chen CH, Petot GJ, Debanne SM. Patients with Alzheimer’s disease have reduced premorbid activities compared to healthy controls. Proceedings of the National Academy of Sciences (USA) 98:3440-3445, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
111. Petot GJ, Debanne SM, Reidel TM,. Smyth KA, Cook TB, Koss E, Lerner AJ, Friedland RP. Surrogate responders do not introduce bias in a case control study of dietary risk factors for Alzheimer’s disease. Journal of the American Dietetic Association 102:848-850, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
110. Bowirrat A, Treves TA, Friedland RP, Korczyn AD. Prevalence of Alzheimer’s type dementia in an elderly Arab population. European Neurology 8:119-123, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
109. Seyidova D, Aliev G, Neal ML, Shi J, Vigano T, Hernandez A, Folco G, Soas AH, Smith MA, Perry G, LaManna JC, Friedland RP.The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cells in vitro. Journal of Submicroscopic Cytology and Pathology 33(1-2):141-9, Jan-Apr 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
108. Demissie S, Green RC, Mucci L, Tziavas S, Martelli K, Bang K, Coons L, Bourque S, Buchillon D, Johnson K, Smith T, Lautenschlager N, Friedland RP, Cupples LA, Farrer LA. Reliability of information collected by proxy in family studies of Alzheimer’s disease. Neuroepidemiology 20:105-111, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
107. Zeng H, Shao H, Menon NK, Yang J, Salomon AR, Friedland RP, Zagorski M. Nicotine and amyloid formation. Biological Psychiatry 49:248-257, 2001. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
106. Aliev, G, Smith, MA, Turmaine, M, Neal ML, Zimina, TV, Friedland, RP, Perry, G, LaManna, JC, Burnstock, G. Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits. Experimental and Molecular Pathology 71, 40-54, 2000 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
105. Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. Neuronal oxidative stress precedes amyloid-Beta deposition in Down’s syndrome. Journal of Neuropathology and Experimental Neurology 59:1011-1017,2000. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
104. Bowirrat A, Friedland, RP, Chapman J, Korczyn AD. Expedited publication:The very high prevalence of Alzheimer’s disease in an Arab population is not explained by high APOE e4 allele frequency. Neurology 55:731, 2000. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
103. Lerner AJ, Elston R, Chen C, Friedland RP. Response of the hypothalamic-pituitary-adrenal axis to lumbar puncture induced stress. Journal of Alzheimer’s Disease 2:193-198, 2000. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
102. Aliev G, Shi J, Perry G, Friedland RP, LaManna J. Decreased constitutive nitric oxide synthase, but increased inducible nitric oxide synthase and endothelin-1 immunoreactivity in aortic endothelial cells of Donryu rats on a cholesterol-enriched diet. The Anatomical Record 259:1-10, 2000. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
101. Shi J, Perry G, Smith MA, Friedland RP. Vascular abnormalities: The insidious pathogenesis of Alzheimer’s disease. Neurobiology of Aging 21:357-361, 2000. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
100. Shi J, Perry G, Aliev G, Smith MA, Ashe KH, Friedland RP. Serum amyloid P is not present in amyloid ß deposits of a transgenic animal model. NeuroReport 10:3229-3232, 1999.
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