Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

  • Professor of Medicine
  • Vice Dean for Research
  • James Graham Brown Foundation Chair in Proteomics
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-588-4710 - Patient Appointments


Clinical Expertise
Diabetic Nephropathy

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: University of Texas Medical Branch (Galveston)
  • Residency: University of Kansas Medical Center (Kansas City)
  • Fellowship: University of Louisville
  • Ph.D.: University of Louisville

 

Featured Publications

  • Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH Jr.. LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease. J Am Soc Nephrol. 2018 Feb;29(2):644-653. doi: 10.1681/ASN.2017060664. Epub 2017 Oct 26. PubMed PMID: 29074737; PubMed Central PMCID: PMC5791069.
  • Merchant ML, Rood IM, Deegens JKJ, Klein JB. Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery. Nat Rev Nephrol. 2017 Dec;13(12):731-749. doi: 10.1038/nrneph.2017.148. Epub 2017 Oct 30. Review. PubMed PMID: 29081510.
  • Arndt DA, Oostveen EK, Triplett J, Allan Butterfield D, Tsyusko OV, Collin B, Starnes DL, Cai J, Klein JB, Nass R, Unrine JM. The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Oct;201:1-10. doi: 10.1016/j.cbpc.2017.08.009. Epub 2017 Sep 6. PubMed PMID: 28888877.
  • Aymé S, Bockenhauer D, Day S, Devuyst O, Guay-Woodford LM, Ingelfinger JR, Klein JB, Knoers NVAM, Perrone RD, Roberts J, Schaefer F, Torres VE, Cheung M, Wheeler DC, Winkelmayer WC; Conference Participants. Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2017 Oct;92(4):796-808. doi: 10.1016/j.kint.2017.06.018. PubMed PMID: 28938953.
  • Wheelock KM, Cai J, Looker HC, Merchant ML, Nelson RG, Fufaa GD, Weil EJ, Feldman HI, Vasan RS, Kimmel PL, Rovin BH, Mauer M, Klein JB; CKD Biomarkers Consortium. Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus. PLoS One. 2017 Jul 10;12(7):e0180964. doi: 10.1371/journal.pone.0180964. eCollection 2017. PubMed PMID: 28700653; PubMed Central PMCID: PMC5507314.
  • Klein JB. Applying proteomics to detect early signs of chronic kidney disease: where has the magic gone? Expert Rev Proteomics. 2017 May;14(5):387-390. doi: 10.1080/14789450.2017.1315303. Epub 2017 Apr 10. PubMed PMID: 28363249.
  • Swomley AM, Triplett JC, Keeney JT, Warrier G, Pearson KJ, Mattison JA, de Cabo R, Cai J, Klein JB, Butterfield DA. Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function. J Nutr Biochem. 2017 Jan;39:169-179. doi: 10.1016/j.jnutbio.2016.10.006. Epub 2016 Oct 13. PubMed PMID: 27840293; PubMed Central PMCID: PMC5665370.
  • Birmingham DJ, Merchant M, Waikar SS, Nagaraja H, Klein JB, Rovin BH. Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise. Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i71-i79. doi: 10.1093/ndt/gfw300. Review. PubMed PMID: 28391335; PubMed Central PMCID: PMC5837441.
  • Triplett JC, Swomley AM, Kirk J, Grimes KM, Lewis KN, Orr ME, Rodriguez KA, Cai J, Klein JB, Buffenstein R, Butterfield DA. Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat. Neurochem Res. 2016 Jul;41(7):1625-34. doi: 10.1007/s11064-016-1877-1. Epub 2016 Mar 2. PubMed PMID: 26935741.
  • Barati MT, Powell DW, Kechavarzi BD, Isaacs SM, Zheng S, Epstein PN, Cai L, Coventry S, Rane MJ, Klein JB. Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice. Cell Stress Chaperones. 2016 Jan;21(1):155-66. PubMed PMID: 26483256; PubMed Central PMCID: PMC4679738.