Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

  • Professor of Medicine
  • Vice Dean for Research
  • James Graham Brown Foundation Chair in Proteomics
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-813-6699 - Patient Appointments


Clinical Expertise
Diabetic Nephropathy

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: University of Texas Medical Branch (Galveston)
  • Residency: University of Kansas Medical Center (Kansas City)
  • Fellowship: University of Louisville
  • Ph.D.: University of Louisville

 

Recent Publications

    • Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG; for the CKD Biomarkers Consortium. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol. 2015 Mar 4. pii: CJN.11541114. [Epub ahead of print] PubMed PMID: 25739849.
    • Barati MT, Lukenbill J, Wu R, Rane MJ, Klein JB. Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABA(B)R-mediated chemotaxis. Cell Signal. 2015 Feb 26. pii: S0898-6568(15)00068-6. doi: 10.1016/j.cellsig.2015.02.022. [Epub ahead of print] PubMed PMID: 25725285.
    • Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Knowler WC, Rovin BH, Wu H, Klein JB, Mifflin TE, Feldman HI, Vasan RS, Kimmel PL, Kusek JW, Mauer M; for the CKD Biomarkers Consortium and the RASS Investigators. Urinary monocyte chemoattractant protein-1 and hepcidin and early diabetic nephropathy lesions in type 1 diabetes mellitus. Nephrol Dial Transplant. 2015 Feb 3. pii: gfv012. [Epub ahead of print] PubMed PMID: 25648911.
    • Triplett J, Zhang Z, Sultana R, Cai J, Klein JB, Büeler H, Butterfield DA. Quantitative Expression Proteomics and Phosphoproteomics Profile of Brain from PINK1 Knockout Mice: Insights into Mechanisms of Familial Parkinson Disease. J Neurochem. 2015 Jan 27. doi: 10.1111/jnc.13039. [Epub ahead of print] PubMed PMID: 25626353.
    • Tomas NM, Beck LH Jr, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RA, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11;371(24):2277-87. doi: 10.1056/NEJMoa1409354. Epub 2014 Nov 13. PubMed PMID: 25394321; PubMed Central PMCID: PMC4278759.
    • Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radic Biol Med. 2014 Nov;76:89-95. doi: 10.1016/j.freeradbiomed.2014.08.006. Epub 2014 Aug 20. PubMed PMID: 25151119; PubMed Central PMCID: PMC4252833.
    • Garbett NC, Merchant ML, Helm CW, Jenson AB, Klein JB, Chaires JB. Detection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry. PLoS One. 2014 Jan 8;9(1):e84710. doi: 10.1371/journal.pone.0084710. eCollection 2014. PubMed PMID: 24416269; PubMed Central PMCID: PMC3885574.
    • Sultana R, Baglioni M, Cecchetti R, Cai J, Klein JB, Bastiani P, Ruggiero C, Mecocci P, Butterfield DA. Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease. Free Radic Biol Med. 2013 Dec;65:595-606. doi: 10.1016/j.freeradbiomed.2013.08.001. Epub 2013 Aug 8. PubMed PMID: 23933528; PubMed Central PMCID: PMC3849349.
    • Keeney JT, Förster S, Sultana R, Brewer LD, Latimer CS, Cai J, Klein JB, Porter NM, Butterfield DA. Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline. Free Radic Biol Med. 2013 Dec;65:324-34. doi: 10.1016/j.freeradbiomed.2013.07.019. Epub 2013 Jul 18. PubMed PMID: 23872023; PubMed Central PMCID: PMC3859828.
    • Fiorini A, Sultana R, Förster S, Perluigi M, Cenini G, Cini C, Cai J, Klein JB, Farr SA, Niehoff ML, Morley JE, Kumar VB, Allan Butterfield D. Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study. Free Radic Biol Med. 2013 Dec;65:1-14. doi: 10.1016/j.freeradbiomed.2013.06.017. Epub 2013 Jun 15. PubMed PMID: 23777706; PubMed Central PMCID: PMC3855183.