Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

  • Professor of Medicine
  • Vice Dean for Research
  • James Graham Brown Foundation Chair in Proteomics
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-588-4710 - Patient Appointments


Clinical Expertise
Diabetic Nephropathy

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: University of Texas Medical Branch (Galveston)
  • Residency: University of Kansas Medical Center (Kansas City)
  • Fellowship: University of Louisville
  • Ph.D.: University of Louisville

 

Recent Publications

      • Triplett JC, Swomley AM, Kirk J, Grimes KM, Lewis KN, Orr ME, Rodriguez KA, Cai J, Klein JB, Buffenstein R, Butterfield DA. Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat. Neurochem Res. 2016 Mar 2. [Epub ahead of print] PubMed PMID: 26935741.
      • Barati MT, Powell DW, Kechavarzi BD, Isaacs SM, Zheng S, Epstein PN, Cai L, Coventry S, Rane MJ, Klein JB. Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice. Cell Stress Chaperones. 2016 Jan;21(1):155-66. PubMed PMID: 26483256; PubMed Central PMCID: PMC4679738.
      • Caster DJ, Hobeika L, Klein JB, Powell DW, McLeish KR. Changing the concepts of immune-mediated glomerular diseases through proteomics. Proteomics Clin Appl. 2015 Dec;9(11-12):967-71. doi: 10.1002/prca.201400159. Epub 2015 Jun 17. PubMed PMID: 25907758; PubMed Central PMCID: PMC4618780.
      • Caster DJ, Korte EA, Merchant ML, Klein JB, Wilkey DW, Rovin BH, Birmingham DJ, Harley JB, Cobb BL, Namjou B, McLeish KR, Powell DW. Autoantibodies targeting glomerular annexin A2 identify patients with proliferative lupus nephritis. Proteomics Clin Appl. 2015 Dec;9(11-12):1012-20. doi: 10.1002/prca.201400175. Epub 2015 Jun 12. PubMed PMID: 25824007; PubMed Central PMCID: PMC4690797.
      • Rovin BH, Klein JB. Proteomics and autoimmune kidney disease. Clin Immunol. 2015 Nov;161(1):23-30. doi: 10.1016/j.clim.2015.04.021. Epub 2015 May 13. Review. PubMed PMID: 25979820; PubMed Central PMCID: PMC4628556.
      • Rood IM, Merchant ML, Wilkey DW, Zhang T, Zabrouskov V, van der Vlag J, Dijkman HB, Willemsen BK, Wetzels JF, Klein JB, Deegens JK. Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy. Proteomics. 2015 Nov;15(21):3722-30. doi: 10.1002/pmic.201500127. Epub 2015 Sep 28. PubMed PMID: 26304790.
      • Triplett JC, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Perluigi M, Buffenstein R, Butterfield DA. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2213-24. doi: 10.1016/j.bbadis.2015.08.002. Epub 2015 Aug 4. PubMed PMID: 26248058.
      • Yang X, Hondur G, Li M, Cai J, Klein JB, Kuehn MH, Tezel G. Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina. Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5816-30. doi: 10.1167/iovs.15-17294. PubMed PMID: 26348630; PubMed Central PMCID: PMC4566415.
      • Triplett JC, Swomley A, Kirk J, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Buffenstein R, Butterfield DA. Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat. J Neurochem. 2015 Aug;134(3):538-50. doi: 10.1111/jnc.13149. Epub 2015 Jun 3. PubMed PMID: 25940666.
      • Barati MT, Lukenbill J, Wu R, Rane MJ, Klein JB. Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABA(B)R-mediated chemotaxis. Cell Signal. 2015 Jun;27(6):1178-85. doi: 10.1016/j.cellsig.2015.02.022. Epub 2015 Feb 26. PubMed PMID: 25725285; PubMed Central PMCID: PMC4381546.