Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

  • Professor of Medicine
  • Vice Dean for Research
  • James Graham Brown Foundation Chair in Proteomics
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-813-6699 - Patient Appointments


Clinical Expertise
Diabetic Nephropathy

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: University of Texas Medical Branch (Galveston)
  • Residency: University of Kansas Medical Center (Kansas City)
  • Fellowship: University of Louisville
  • Ph.D.: University of Louisville

 

Recent Publications

  • Garbett NC, Merchant ML, Helm CW, Jenson AB, Klein JB, Chaires JB. Detection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry. PLoS One. 2014 Jan 8;9(1):e84710. doi: 10.1371/journal.pone.0084710. eCollection 2014. PubMed PMID: 24416269; PubMed Central PMCID: PMC3885574.
  • Sultana R, Baglioni M, Cecchetti R, Cai J, Klein JB, Bastiani P, Ruggiero C, Mecocci P, Butterfield DA. Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease. Free Radic Biol Med. 2013 Dec;65:595-606. doi: 10.1016/j.freeradbiomed.2013.08.001. Epub 2013 Aug 8. PubMed PMID: 23933528; PubMed Central PMCID: PMC3849349.
  • Keeney JT, Förster S, Sultana R, Brewer LD, Latimer CS, Cai J, Klein JB, Porter NM, Allan Butterfield D. Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline. Free Radic Biol Med. 2013 Dec;65:324-34. doi: 10.1016/j.freeradbiomed.2013.07.019. Epub 2013 Jul 18. PubMed PMID: 23872023; PubMed Central PMCID: PMC3859828.
  • Fiorini A, Sultana R, Förster S, Perluigi M, Cenini G, Cini C, Cai J, Klein JB, Farr SA, Niehoff ML, Morley JE, Kumar VB, Allan Butterfield D. Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study. Free Radic Biol Med. 2013 Dec;65:1-14. doi: 10.1016/j.freeradbiomed.2013.06.017. Epub 2013 Jun 15. PubMed PMID: 23777706; PubMed Central PMCID: PMC3855183.
  • Garbett NC, Merchant ML, Chaires JB, Klein JB. Calorimetric analysis of the plasma proteome: identification of type 1 diabetes patients with early renal function decline. Biochim Biophys Acta. 2013 Oct;1830(10):4675-80. doi: 10.1016/j.bbagen.2013.05.007. Epub 2013 May 10. PubMed PMID: 23665587; PubMed Central PMCID: PMC3743444.
  • McLeish KR, Merchant ML, Klein JB, Ward RA. Technical note: proteomic approaches to fundamental questions about neutrophil biology. J Leukoc Biol. 2013 Oct;94(4):683-92. doi: 10.1189/jlb.1112591. Epub 2013 Mar 7. Review. PubMed PMID: 23470899.
  • Baba SP, Hoetker JD, Merchant M, Klein JB, Cai J, Barski OA, Conklin DJ, Bhatnagar A. Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates. J Biol Chem. 2013 Sep 27;288(39):28163-79. doi: 10.1074/jbc.M113.504753. Epub 2013 Aug 8. PubMed PMID: 23928303; PubMed Central PMCID: PMC3784727.
  • Merchant ML, Niewczas MA, Ficociello LH, Lukenbill JA, Wilkey DW, Li M, Khundmiri SJ, Warram JH, Krolewski AS, Klein JB. Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes. Kidney Int. 2013 Jun;83(6):1177-84. doi: 10.1038/ki.2013.8. Epub 2013 Mar 6. PubMed PMID: 23466993.
  • Klein J. Biomarkers that predict diabetic nephropathy: the long road from finding targets to clinical use. Diabetes. 2012 Dec;61(12):3072-3. doi: 10.2337/db12-1299. PubMed PMID: 23172957; PubMed Central PMCID: PMC3501855.
  • Lederer ED, Klein JB. New treatments for CKD--new insights into pathogenesis. J Am Soc Nephrol. 2012 Oct;23(10):1601-3. Epub 2012 Sep 13. PubMed PMID: 22975668; PubMed Central PMCID: PMC3458472.