Roberto Bolli, M.D., FAHA, FACC

Roberto Bolli, M.D., FAHA, FACC

Robert Bolli, M.D.

Roberto Bolli, M.D., FAHA, FACC

  • Professor of Medicine, Physiology and Biophysics
  • Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology
  • Chief, Division of Cardiovascular Medicine
  • Executive Vice Chair, Department of Medicine
  • Director, Institute of Molecular Cardiology
  • Scientific Director, Cardiovascular Innovation Institute
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7959 - Academic Office

Clinical Expertise
Cardiology; Cardiovascular Disease


Board Certification

  • American Board of Internal Medicine -
    Internal Medicine / Cardiovascular Disease

Education and Training

  • Medical School: University of Perugia, Italy
  • Residency: Baylor College of Medicine
  • Fellowship: National Institutes of Health; Baylor College of Medicine



Featured Publications

  • Wysoczynski M, Guo Y, Moore JB 4th, Muthusamy S, Li Q, Nasr M, Li H, Nong Y, Wu W, Tomlin AA, Zhu X, Hunt G, Gumpert AM, Book MJ, Khan A, Tang XL, Bolli R. Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence. J Am Coll Cardiol. 2017 Apr 11;69(14):1824-1838. doi: 10.1016/j.jacc.2017.01.048. PubMed PMID: 28385312.
  • Tokita Y, Tang XL, Li Q, Wysoczynski M, Hong KU, Nakamura S, Wu WJ, Xie W, Li D, Hunt G, Ou Q, Stowers H, Bolli R. Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration: A New Paradigm in Cell Therapy. Circ Res. 2016 Aug 19;119(5):635-51. doi: 10.1161/CIRCRESAHA.116.308937. Epub 2016 Jun 30. PubMed PMID: 27364016; PubMed Central PMCID: PMC4992406.
  • Bolli R. Repeated Cell Therapy: A Paradigm Shift Whose Time Has Come. Circ Res. 2017 Mar 31;120(7):1072-1074. doi: 10.1161/CIRCRESAHA.117.310710. Epub 2017 Feb 8. PubMed PMID: 28179431; PubMed Central PMCID: PMC5384469.
  • Bolli R, Ghafghazi S. Stem cells: Cell therapy for cardiac repair: what is needed to move forward? Nat Rev Cardiol. 2017 Mar 31. doi: 10.1038/nrcardio.2017.38. [Epub ahead of print] PubMed PMID: 28361979.
  • Al-Maqtari T, Hong KU, Vajravelu BN, Moktar A, Cao P, Moore JB 4th, Bolli R. Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells. PLoS One. 2017 Mar 29;12(3):e0174242. doi: 10.1371/journal.pone.0174242. eCollection 2017. PubMed PMID: 28355297; PubMed Central PMCID: PMC5371315.
  • Khan AR, Farid TA, Pathan A, Tripathi A, Ghafghazi S, Wysoczynski M, Bolli R. Impact of Cell Therapy on Myocardial Perfusion and Cardiovascular Outcomes in Patients With Angina Refractory to Medical Therapy: A Systematic Review and Meta-Analysis. Circ Res. 2016 Mar 18;118(6):984-93. doi: 10.1161/CIRCRESAHA.115.308056. Epub 2016 Jan 13. Review. PubMed PMID: 26838794; PubMed Central PMCID: PMC4798914.
  • Guo Y, Wysoczynski M, Nong Y, Tomlin A, Zhu X, Gumpert AM, Nasr M, Muthusamy S, Li H, Book M, Khan A, Hong KU, Li Q, Bolli R. Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction. Basic Res Cardiol. 2017 Mar;112(2):18. doi: 10.1007/s00395-017-0606-5. Epub 2017 Feb 16. PubMed PMID: 28210871.
  • Tang XL, Li Q, Rokosh G, Sanganalmath SK, Chen N, Ou Q, Stowers H, Hunt G, Bolli R. Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year. Circ Res. 2016 Apr 1;118(7):1091-105. doi: 10.1161/CIRCRESAHA.115.307647. Epub 2016 Feb 2. PubMed PMID: 26838790; PubMed Central PMCID: PMC4818175.
  • Perin EC, Murphy MP, March KL, Bolli R, Loughran J, Yang PC, Leeper NJ, Dalman RL, Alexander JQ, Henry TD, Traverse JH, Pepine CJ, Anderson RD, Berceli S, Willerson JT, Muthupillai R, Gahremanpour AA, Raveendran G, Velazquez OC, Hare JM, Schulman IH, Kasi VS, Hiatt WR, Ambale-Venkatesh B, Lima JA, Taylor DA, Resende MM, Gee AP, Durett AG, Bloom J, Richman S, G'Sell P, Williams S, Khan F, Ross EG, Santoso MR, Goldman J, Leach D, Handberg E, Cheong BY, Piece NA, DiFede D, Bruhn-Ding B, Caldwell E, Bettencourt J, Lai D, Piller LB, Simpson LM, Cohen M, Sayre SL, Vojvodic RW, Moyé L, Ebert RF, Simari RD, Hirsch AT; Cardiovascular Cell Therapy Research Network (CCTRN).. Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial. Circulation. 2017 Feb 16. pii: CIRCULATIONAHA.116.025707. doi: 10.1161/CIRCULATIONAHA.116.025707. [Epub ahead of print] PubMed PMID: 28209728.
  • Contreras A, Orozco AF, Resende M, Schutt RC, Traverse JH, Henry TD, Lai D, Cooke JP, Bolli R, Cohen ML, Moyé L, Pepine CJ, Yang PC, Perin EC, Willerson JT, Taylor DA; Cardiovascular Cell Therapy Research Network (CCTRN).. Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials. Basic Res Cardiol. 2017 Jan;112(1):3. Epub 2016 Nov 23. PubMed PMID: 27882430.
  • Khan AR, Bavishi C, Riaz H, Farid TA, Khan S, Atlas M, Hirsch G, Ikram S, Bolli R. Increased Risk of Adverse Neurocognitive Outcomes With Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors. Circ Cardiovasc Qual Outcomes. 2017 Jan;10(1). pii: e003153. doi: 10.1161/CIRCOUTCOMES.116.003153. PubMed PMID: 28073851.
  • Moore JB 4th, Zhao J, Keith MC, Amraotkar AR, Wysoczynski M, Hong KU, Bolli R. The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism. Stem Cells. 2016 Dec;34(12):2916-2929. doi: 10.1002/stem.2471. Epub 2016 Sep 1. PubMed PMID: 27501845; PubMed Central PMCID: PMC5123951.