Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

  • Associate Professor of Medicine
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Hepatology; Nutrition; Liver Transplantation

 

Board Certifications

  • American Board of Internal Medicine -
    Gastroenterology / Transplant Hepatology

Education and Training

  • Medical School: University of Kentucky
  • Residency: Washington University Barnes-Jewish Hospital
  • Fellowship: University of Louisville

 

Featured Publications

  • Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals. Toxicol Sci. 2018 Apr 1;162(2):622-634. doi: 10.1093/toxsci/kfy004. PubMed PMID: 29329451; PubMed Central PMCID: PMC5888991.
  • Song M, Li X, Zhang X, Shi H, Vos MB, Wei X, Wang Y, Gao H, Rouchka EC, Yin X, Zhou Z, Prough RA, Cave MC, McClain CJ. Dietary copper-fructose interactions alter gut microbial activity in male rats. Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G119-G130. doi: 10.1152/ajpgi.00378.2016. Epub 2017 Oct 12. PubMed PMID: 29025734; PubMed Central PMCID: PMC5866377.
  • Hardesty JE, Wahlang B, Falkner KC, Clair HB, Clark BJ, Ceresa BP, Prough RA, Cave MC. Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling. Xenobiotica. 2017 Sep;47(9):807-820. doi: 10.1080/00498254.2016.1217572. Epub 2017 Jun 21. PubMed PMID: 27458090; PubMed Central PMCID: PMC5512701.
  • McClain C, Vatsalya V, Cave M. Role of Zinc in the Development/Progression of Alcoholic Liver Disease. Curr Treat Options Gastroenterol. 2017 Jun;15(2):285-295. doi: 10.1007/s11938-017-0132-4. Review. PubMed PMID: 28447197.
  • Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ. Safety Assessment of Liver Injury with Quetiapine Fumarate XR Management in Very Heavy Drinking Alcohol-Dependent Patients. Clin Drug Investig. 2016 Nov;36(11):935-944. PubMed PMID: 27503091; PubMed Central PMCID: PMC5095696.
  • Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ. Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients. Alcohol Clin Exp Res. 2016 Oct;40(10):2085-2093. doi: 10.1111/acer.13197. Epub 2016 Sep 2. PubMed PMID: 27589090; PubMed Central PMCID: PMC5367046.
  • Cave MC, Clair HB, Hardesty JE, Falkner KC, Feng W, Clark BJ, Sidey J, Shi H, Aqel BA, McClain CJ, Prough RA. Nuclear receptors and nonalcoholic fatty liver disease. Biochim Biophys Acta. 2016 Sep;1859(9):1083-1099. doi: 10.1016/j.bbagrm.2016.03.002. Epub 2016 Mar 4. Review. PubMed PMID: 26962021; PubMed Central PMCID: PMC5149456.
  • Liu Y, Zhao C, Xiao J, Liu L, Zhang M, Wang C, Wu G, Zheng MH, Xu LM, Chen YP, Mohammadi M, Chen SY, Cave M, McClain C, Li X, Feng W. Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. Sci Rep. 2016 Aug 8;6:31026. doi: 10.1038/srep31026. PubMed PMID: 27498701; PubMed Central PMCID: PMC4976373.
  • Crittenden NE, Buchanan LA, Pinkston CM, Cave B, Barve A, Marsano L, McClain CJ, Jones CM, Marvin MR, Davis EG, Kuns-Adkins CB, Gedaly R, Brock G, Shah MB, Rosenau J, Cave MC. Simeprevir and sofosbuvir with or without ribavirin to treat recurrent genotype 1 hepatitis C virus infection after orthotopic liver transplantation. Liver Transpl. 2016 May;22(5):635-43. doi: 10.1002/lt.24422. PubMed PMID: 26915588.
  • Song M, Chen T, Prough RA, Cave MC, McClain CJ. Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response. Alcohol Clin Exp Res. 2016 Mar;40(3):518-28. doi: 10.1111/acer.12994. Epub 2016 Feb 9. PubMed PMID: 26858005; PubMed Central PMCID: PMC5517020.