Cycle 8- July 2024 TRSC Core Utilization Subsidy Program (CUSP) Awards

New Hypothesis Expansion/Direction Medium TRSC Research Voucher Award(s): Medium research voucher applications support the expenses (up to $5,000) associated with critical exploratory research and proof-of-concept studies needed by CIEHS members for hypothesis generation and grant (re)submission.

Principal Investigator: Jiapeng Huang, M.D., Ph.D.
Collaborators: Lu Cai, M.D., Ph.D. and Maiying Kong, Ph.D.
Title: Statistical Analysis of the Pulmonary Arterial Hypertension Biobank Clinical Data and Metallomics
Lay Description: The causes of pulmonary arterial hypertension (PAH) is extremely complex, involving genetic, epigenetic, environmental factors, inflammation, oxidative stress, and metabolic transformation. There is no effective therapy currently. This proposal will comprehensively analyze the clinical data in the PAH Biobank, integrate metallomics data with clinical data, identify significant risk factors for worse PAH clinical outcomes, and design well controlled clinical trials to optimize metal concentrations in PAH.