Cycle 6- March 2023 TRSC Research Voucher Awards

New Hypothesis Expansion/Direction Medium IHSFC Research Voucher Award(s):Medium research voucher applications support the expenses (up to $5,000) associated with critical exploratory research and proof-of-concept studies needed by CIEHS members for hypothesis generation and grant (re)submission.

Principal Investigator: Jiapeng Huang, M.D., Ph.D.
Collaborator:Lu Cai, M.D., Ph.D.; Jun Cai, M.D., Ph.D.
Title: Effects And Mechanisms of Antimony During Pulmonary Arterial Hypertension Pathogenesis
Lay Description: The etiology of pulmonary arterial hypertension (PAH) is extremely complex, involving genetic, epigenetic, and environmental factors. We hypothesize that heavy metal, antimony, may directly induce PAH, and would significantly facilitate the development or worsen the pathogenesis of PAH via disturbance of the redox homeostasis. We aim to examine effects of antimony on PAH and right ventricular dysfunction by direct exposure, which will shed light on roles of low dose antimony exposure in PAH pathogenesis and help identify novel therapeutic targets for PAH.