CENTER OF EXCELLENCE FOR APPLIED MICROCIRCULATORY RESEARCH





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Seminars       Personnel     Grants     Publications    Positions   

 

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Seminars

March 16, 1999

HSC Dental School room 105

Dr. Stanley D'Souza

Cleveland Clinic Foundation

"Cell Proliferation and Signaling Mediated through Fibrinogen interactions with ICAM-1

 

June 15, 1999

HSC A1212 9:00am

Dr. Ranjeet S. Ajmani,  Ph.D.

National Institutes of Health

Bethesda, MD

Dr. Ajmani will speak  on "Oxidative Stress: Hemorheological Changes and Cerebral Blood Flow". 

 

July 26, 1999

HSC A1212 9:00am

Dr. Mark Davis,  Ph.D.

Meharry Medical College

Nashville, TN

Dr. Davis will speak  on "Involvement of Gia2 in Sodium Butyrate-Induced Erythoblastic Differentiation of K562 Cells". 

 

 

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Personnel

New Associates

Dr. Alex Lentsch, Ph.D.is an Assistant Professor of Surgery who joined the Center as an Associate in the spring of 1999.  He is studying mechanisms of cell activation.

Dr. Robert Keynton, Ph.D. is an Assistant Professor of Mechanical Engineering who joined the Center as an Associate in the summer of 1999.  He is studying blood flow alterations in vascular bypass grafts.

 

Visiting Scientist

Mohammed M. Maleque, D.V.M. and Ph.D.

Associate Professor of Pharmacolgoy and Toxicology

Meharry Medical College

Dr. Maleque is visiting the laboratories of Dr. Ayo Adeagbo in July, 1999.

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Grants

Dr. Frederick Miller, Steven Myers and Leslie Schuschke have received a grant for $53,800 from the WHAS crusade for Children for the purchase of a Capillary Electrophoresis System. This system will provide analysis of drugs and endogenous compounds from very small samples (microliters). It is anticipated that it will be a significant help for the CAMR in understanding microvascular phenomena.

Dr. Nancy Alsip has received a grant from the American Heart Association, Kentucky Affiliate for $30,000 a year from 7/98-6/00.  Her grant is entitled " Uterine and mesenteric microvessel release of nitric oxide in an experimental model of rodent pre-eclampsia"

Dr. Wei-"Zhong Wang has received a grant from the Orthopaedic Research and Education Foundation for $64,059 from 7/98-6/00.  His grant is entitled "The role of platelet-activating factor in ischemia/reperfusion injury of skeletal muscle".

Dr. Patrick D. Harris is a co-investigator on a grant with CAMR Associate Dr. David Spain entitlted "Intestinal Microvascular Control During the Trauma of Hemorrhagic Shock".  the grant is from the Veterans Administration (National Merit Review) and is for $92,000 a year from 12/98-11/02.  Dr. Harris is also co-investigator on another grant with CAMR Associate Dr. Neal Garrison from the same agency.  It is entitlted "Intestinal Microvascular Response to (the combination of ) Hemorrhage and Sepsis.  This grant is for $103,880 per year from 4/98-3/01

Dr. Dale Schuschke has received a grant from National Institutes of Health entitled "Leukocyte Adhesion in Copper Deficient Microcirculation.  The grant is for $326,000 and will be active from 7/1/99-6/30/03.

Dr. Bill Ehringer has received a grant from The American Heart Association, Ohio Valley Affiliate.  The grant is entitled "The Role of Matrix Metalloproteinases in Endothelial Permeability". The grant is for $69,279 and is active from 7/1/99-6/30/01.

Dr. Jurandir J. Dalle Lucca has received a fellowship grant from The American Heart Association, Ohio Valley Affiliate that will be active from 7/1/99-6/30/01.

 

 

 

 

 

 

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Recent Manuscripts

 

 

B. PUBLICATIONS: DEFINITIVE MANUSCRIPTS

 

1. Carroll, C.M.A., S.M. Carroll, D.A. Schuschke and J.H. Barker. Augmentation of skeletal muscle flap survival using platelet derived growth factor. Plastic and Reconstructive Surg. 102:407-415, 1998.

2. Ehringer, W.D., M.J. Edwards, K.A. Wintergerst, A. Cox and F.N.Miller. An increase in endothelial intracellular calcium and F-actin precedes the extravasation of interleukin-2 activated lymphocytes. Microcirculation 5:71-80, 1998.

3. Franken, RJPM, F.W. Peter, G.L. Anderson, W.Z. Wang, D.A. Schuschke, M. Kon, and J.H. Barker. Anatomy of the feeding blood vessels of the cremaster muscle in the rat. Microsurgery 17(7):402-408, 1998.

4. Fruchterman, T.M., D.A. Spain, M.A. Wilson, P.D. Harris, and R.N. Garrison: Complement inhibition prevents gut ischemia and endothelial dysfunction after hemorrhage/resuscitation. Surgery 124 #4:782-792, 1998.

5. Fruchterman, T.M., D.A. Spain, M.A. Wilson, P.D. Harris, and R.N. Garrison: Selective microvascular endothelial cell dysfunction in the small intestine following resuscitated hemorrhagic shock. Shock 10 #5:386-390, 1998.

6. Fruchterman, T.M., D.A. Spain, P.J. Matheson, A.W. Martin, M.A. Wilson, P.D. Harris, and R.N. Garrison. Nitric oxide metabolites are decreased in the rat mesenteric circulation following resuscitated hemorrhage. J. Surg. Res. 80:102-109, 1998.

7. Fruchterman, T.M., D.A. Spain, P.J. Matheson, A.W. Martin, M.A. Wilson, P.D.Harris, and R.N. Garrison: Small intestinal production of Nitric Oxide is decreased following resuscitated hemorrhage. J. Surgical Res. 80:102-109, 1998.

8. Garrison, R.N., D.A. Spain, M.A. Wilson, P.A. Keelen, and P.D. Harris. Microvascular changes explain the two-hit theory for multiple organ failure. Ann. Surgery 227:851-860, 1998.

9. Heinzelmann, M., A. Platz, H. Flodgaard, and F.N. Miller. Heparin binding protein (CAP37) is an opsonin for staphylococcus aureus and increases phagocytosis in monocytes. Inflammation 22; 493-507, 1998.

10. Heinzelmann, M., H.C. Polk, and F.N.Miller. Modulation of Lipopolysaccharide-Induced Monocyte Activation by Heparin-Binding Protein and Fucoidan. Infection and Immunity, 66:5842-5847, 1998.

11. Lentsch, A.B., H. Yoshidome, W.G. Cheadle, F.N. Miller, M.J. Edwards. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: Roles for macrophage inflammatory protein-2 and KC. Hepatology 27: 1172-1177, 1998.

12. Lentsch, A.B., M.J. Edwards, D.E. Sims, and F.N. Miller. N˙-nitro-L-arginine methyl ester inhibits inflammatory liver injury induced by interleukin-2. J. Leuk. Biol. 63:22-30, 1998.

13. Lominadze, D., I.G. Joshua and D.A. Schuschke. Increased erythrocyte aggregation in spontaneously hypertensive rats. Am. J. Hypertension. 11:784-789, 1998.

14. Lominadze, D., I.G. Joshua, J.L. Catalfamo and D.A. Schuschke. Platelet thrombus formation in microvessels of young spontaneously hypertensive rats. Clin. Exp. Hypertension. 20:917-937, 1998.

15. Lübbe, Andreas S., Patrick D. Harris, and R. Neal Garrison. E. Coli-Bacteremia-Induced Changes in the Skeletal Muscle Microcirculation Vary with Anesthetics. Croatian Medical Journal 39(4):x-x, 1998.

16. Peter, F. W., D.A. Schuschke, W.Z. Wang, G.L. Anderson, R.J.P.M. Franken, J.M. Gu, S. Pierangeli, and J.H. Barker. Do leukocytes contribute to impaired microvascular tissue perfusion after arterial repair? Microsurgery 18:23-28,1998.

17. Peter, F.W., D.A. Schuschke, J.H. Barker, B. Fleischer-Peter, and H.U. Steinau. Leukocyte behavior in a free-flap model following chemotherapy and application of granulocyte colony-stimulating factor (GCSF). Microsurgery 18:290-297, 1998.

18. Reid, K.H., B. Patenaude, S.Z. Guo, and V.G. Iyer. Carbon dioxide narcosis-induced apnea in a rat model of cardiac arrest and resuscitation. Resusc. 38:185-191, 1998.

19. Saha P.R., N.L. Alsip, and E.F. Asher. Role of nitric oxide and cyclooxygenae products in controlling vasuclar tone in uterine microvessels of the rat. J Reprod Fertil. 112:211-216, 1998.

20. Wang, W.Z., G. Anderson, J. Firrell, and T.M. Tsai. Ischemic preconditioning vs. Intermittent reperfusion to improve blood flow to a vascular isolated skeletal muscle flap of rats J of Trauma 45 (5):953-959, 1998.

21. Yoshidome, H., A.B. Lentsch, W.G. Cheadle, F.N. Miller, M.J. Edwards. Enhanced pulmonary expression of CXC chemokines during hepatic ischemia/reperfusion-induced lung injury in mice. Journal of Surgical Research 81: 33-37, 1999.

                          22. Zhao H., and I.G. Joshua. Release of endogenous                             nitric oxide mediates arteriolar dilation to endothelin in rat                             striated muscle. Journal of Cardiovascular Pharmacology.                             31:331-335, 1998.

 

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Positions

POST-DOCTORAL FELLOWS

      The Center for Applied Microcirculatory Research (CAMR) at the University of Louisville has two post-doctoral research positions immediately available. Current research in the CAMR involves microcirculatory studies and cell physiology studies that impact human disease. The first post-doctoral position involves the role of trace element nutrition in microvascular control mechanisms, with an emphasis on inflammatory pathways, angiogenesis and tumor vasculature. The second post-doctoral position will examine the intracellular signal transduction mechanisms involved in endothelial macromolecular permeability, with an emphasis on protein kinases, cytoskeletal proteins, and matrix metalloproteinases. Candidates should have some expertise in at least one of the following categories: trace element nutrition, vascular biology, cell physiology, physiology, or biochemistry. However, other applicants will be considered. Applicants must have a Ph.D. and/or M.D. degrees and be a citizen or permanent resident of the United States. Please send a curriculum vitae and the names of three references to either Dale Schuschke, Ph.D., (daschu01@gwise.louisville.edu) or William Ehringer, Ph.D.,(wdehri01@gwise.louisville.edu) Center For Applied Microcirculatory Research, University of Louisville School of Medicine, 500 S. Preston Street, Louisville, KY, 40292. The University of Louisville is an Equal Opportunity/Affirmative Action Employer.

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