Michael Tseng, Ph.D.

Professor

Department of Anatomical Sciences & Neurobiology


502-852-5170 mttsen01@louisville.edu

Dr. Tseng, trained as an experimental pathologist, has long been interested in tissue responses to xenobiotics. Among the topics to which he has contributed are experimental chemotherapy, photodynamic therapy, cerebral ischemia and neuroprotectant screening. The recent surge of development of nanomaterials for biomedical uses had led to Dr. Tseng’s current focus on drug delivery for cancer therapy and in facilitating wound healing through direct energy delivery. Central to his approach is the deployment of HRTEM, STEM, and EDS for direct localization of nanomaterial in cells, tissue, and organs. Combining his years of experience in ultrastructural pathology, he anticipates major contribution to the emerging field of nanotoxicology.

Representative Publications

Yokel, R.A., Florence, R.L., Unrine, J.M., Tseng, M.T., Graham, U.M., Wu, P., Grulke, E.A., Sultana, R., Hardas, S.S., Butterfield, D.A. Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial. 2009, Nanotoxicology, 3(3).

Sonaje K, Lin KJ, Tseng MT, Wey SP, Su FY, Chuang EY, Hsu CW, Chen CT, Sun HW, Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins, 2011Biomaterials. 32(33):8712-21.

Yeh TH, Hsu LW, Tseng M.T., Lee PL, Sonjae K, Ho YC, Sung HW, Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening, 2011, Biomaterials, 32(26):6164-73.

Peng SF, Tseng M.T., Ho YC, Wei MC, Liao ZX, Sung HW, Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(γ-glutamic acid) complexes as a gene delivery vector, 2011,Biomaterials.32(1):239-48.

Tsyusko O, Unrine J, Spurgeon D, Blalock E, Starnes D, Tseng, M, Joice G, Bertsch P, Toxicogenomic Responses of the Model Organism Caenorhabditis elegans to Gold Nanoparticles, 2012, Environmental Science & Technology (in press).

Yokel R.A., Au T.C., MacPhail R, Hardas S.S., Butterfield D. Allan, Sultana R, Goodman M, Tseng M.T., Dan M, Haghnazar H, Unrine J.M., Graham U.M., Wu P, and Grulke E.A., Distribution, Elimination, and Biopersistence to 90 Days of a Systemically introduced 30 nm Ceria-Engineered Nanomaterial in Rats, 2012, Toxicological Sciences (in press).

Sonaje K, Chuang E.Y., Lin K.J., Yen T.C., Su F.Y., Tseng M.T., Sung H.W., Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultra-structural and computed-tomographic observations, 2012, Molecular Pharmaceutics (In press).

Tseng M.T., Lu X, Duan X, Hardas S.S., Sultana R, Wu P, Unrine J.M., Graham U, Butterfield D. Allan, Grulke E.A., Yokel R.A., Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria, 2012, Toxicology and Applied Pharmacology (In press).