Associate Professor of Chemistry

Phone Number: 502-852-8878
Email xiang.zhang@louisville.edu

Address: University of Louisville
Department of Chemistry
Louisville, KY 40292

Additional Appointments:

• Director, CREAM Center

Education:

• 1989 B.S.   Lanzhou University
• 1994 M.S.  Institute of Modern Physics, Chinese Academy of Sciences
• 2001 Ph. D. Purdue University

Laboratory Team Members:

Research Focus:

We exploit practical and efficient high throughput technologies for the analyses of complex mixtures derived from living systems. This will facilitate the development of preventive, predictive, personalized and participatory medicine for specific diseases and will promote health and wellness. We use a number of high throughput analytical platforms including multidimensional liquid chromatography - mass spectrometry (MDLC-MS) for proteomics, multidimensional liquid chromatography - mass spectrometry (MDLC-MS) and two dimensional gas chromatography - mass spectrometry (GC×GC-MS) for metabolomics. Using the high information content data generated from these analytical platforms, we develop advanced bioinformatic algorithms and data analysis tools for the discovery of molecular expression, correlation, and interaction networks in biological systems.

Selected Publications:

• Salabei, J.K.; Lorkiewicz, P.K.; Mehra, P.; Gibb, A.A.; Haberzettl, P.; Hong, K.U.; Wei, X.; Zhang, X.; Li, Q.; Wysoczynski, M.; Bolli, R.; Bhatnagar, A.; Hill, B.G. Type 2 diabetes dysregulates glucose metabolism in cardiac progenitor cells. J. Biol. Chem. 2106, 26, 13634-13648.
• Carlisle, S.M.; Trainor, P.J.; Yin, X.; Doll, M.A.; States, J.C.; Zhang, X.; Hein, D.W. Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1. Metabolomics 2106. 12:111.
• Liu, R.; Wu, D.; Zhang, X.; Kim, S. Compound identification using penalized linear regression in metabolomics. J. Mod. Appl. Stat. Meth. 2016, 15(1), 373-388.
• Koo, I.; Kim, S.; Shi, B.; Lorkiewicz, P.; Song, M.; McClain, C.; Zhang, X. EIder: a compound identification tool for gas chromatography-mass spectrometry data. J. Chromatogr. A 2016, 1448, 107-114.
• Chung, D.; Golden, J.E.; Adcock, R.S.; Chu, Y.; Sotsky, J.B.; Cramer, D.E.; Chilton, P.M.; Song, C.; Anantpadma, M.; Schroeder, C.E.; Prodhan, A.I.; Yin, X.; Zhang, X. Discovery of a broad-spectrum antiviral compound that inhibits pyrimidine biosynthesis and establishes a type 1 interferon-independent antiviral state. Antimicrob. Agents Chemother. 2106, 60(8), 4552-4562.
• Luo, M.; Luo, P.; Zhang, Z.; Payne, K.; Watson, S.; Wu, H.; Tan, Y.; Ding, Y.; Sun, W.; Yin, X.; Zhang, X.; Liu, G.; Wintergerst, K.; Miao, L.; Cai, L. Zinc delays the progression of obesity-related glomerulopathy in mice via down-regulating P38 MAPK-mediated inflammation. Obesity, 2016, 24(6), 1244-1256.
• Kim, S.; Koo, I.; Zhang, X. Normal-Gamma-Bernoulli peak detection for analysis of comprehensive two-dimensional gas chromatography mass spectrometry data. Comput. Stat. Data Anal. 2016, in press.
• Kirpich, I.A.; Petrosino, J.;  Ajami, N.; Feng, W.; Wang, Y.; Liu, Y.; Beier, J.I.; Barve, S.S.; Yin, X.; Wei, X.; Zhang, X.; McClain, C.J. Saturated and unsaturated dietary fats differentially modulate ethanol-induced changes in gut microbiome and metabolome in a mouse model of alcoholic liver disease. Am. J. Pathol. 2016, 186(4), 765-776. (PMID: 27012191)
• Zhang, J.; Xia, Y.; Zheng, H.; Wang, B.; Zhang, X.; Chen, P. Combine multiple mass spectral similarity measures for compound identification. Int. J. Data Mining and Bioinformatics 2016, 15(1), 84-100.
• Zhong, W.; Li, Q.; Sun, Q.; Zhang, W.; Zhang, J.; Sun, X.; Yin, X.; Zhang, X.; Zhou, Z. Preventing gut leakiness and endotoxemia contributes to the protective effect of zinc on alcohol-induced steatohepatitis in rats. J. Nutr. 2015, 145, 2690-2698.
• Wei, X.; Song, M.; Yin, X.; Schuschke, D.A.; McClain, C.J.; Zhang, X. Effects of dietary different doses of copper and high fructose feeding on rat fecal metabolome. J. Proteome Res. 2015, 14(9), 4050-4058.
• Kim, S.; Lee, J.; Jang, H.; Zhang, X. Metabolic network construction using ensemble algorithms. The First International Workshop on Bioinformatics.. Dec. 3-5, 2015. New York City, NY, USA. [Conference paper].