Chair in Organic Chemistry from the University of Louisville

Phone Number: (502) 852-5998 (Office)
Fax Number: (502) 852-3899
Email: gbhamm01@louisville.edu

Department of Chemistry; University of Louisville;
Louisville, KY 40292

Additional Appointments:

• Program Director, Chemistry Division, National Science Foundation, Arlington, Virginia
• Professor of Chemistry & University Scholar

Education:

• 1975 B.S.   Pontificia Universidad Catolica del Peru in Lima, Peru
• 1979 M.S.  University of British Columbia, Vancouver, Canada
• 1985 Ph.D. University of Birmingham, England

Laboratory Team Members:

Research Focus:

Synthetic methods development using fluorine

Targeting neglected diseases and cancer using bioinspired compounds

Streamlining chemical synthesis using supported organic phases

Selected Publications:

• Zhou Li, Gerald B. Hammond, Bo Xu, Quantification of hydrogen fluoride-based reagents using a bifunctional NMR internal standard, Journal of Fluorine Chemistry, Volume 184, April 2016, Pages 72-74, ISSN 0022-1139.
• Shengzong Lianga, Paige Monsena, Gerald B. Hammonda and Bo Xub, Au/TiO2 catalyzed reductive amination of aldehydes and ketones using formic acid as reductant, Org. Chem. Front., 2016, 3, 505-509. DOI: 10.1039/C5QO00439J.
• Liang S, Hammond GB, Xu B. Supported gold nanoparticles catalyzed cis-selective semihydrogenation of alkynes using ammonium formate as the reductant. Chem Commun (Camb). 2016 May 21;52(35):6013-6. PubMed PMID: 27063707.
• Rene E. Ebule1, Deepika Malhotra1, Gerald B. Hammond1,* and Bo Xu2, Ligand Effects in the Gold Catalyzed Hydration of Alkynes Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, United States, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China, Advanced Synthesis & Catalysis.   DOI: 10.1002/adsc.201501079
• Angnes RA, Li Z, Correia CR, Hammond GB. Recent synthetic additions to the visible light photoredox catalysis toolbox. Org Biomol Chem. 2015 Sep 21;13(35):9152-67. PubMed PMID: 26242759.
• Han J, Lu Z, Wang W, Hammond GB, Xu B. Potassium tris(triflyl)methide (KCTf3): a broadly applicable promoter for cationic metal catalysis. Chem Commun (Camb). 2015 Sep 18;51(72):13740-3. PubMed PMID: 26189825.
• Lu Z, Han J, Hammond GB, Xu B. Revisiting the Influence of Silver in Cationic Gold Catalysis: A Practical Guide. Org Lett. 2015 Sep 18;17(18):4534-7. PubMed PMID: 26335841.
• Okoromoba OE, Hammond GB, Xu B. Preparation of Fluorinated Tetrahydropyrans and Piperidines using a New Nucleophilic Fluorination Reagent DMPU/HF. Org Lett. 2015 Aug 21;17(16):3975-7. PubMed PMID: 26262944.
• Han J, Lu Z, Flach AL, Paton RS, Hammond GB, et al. Role of Hydrogen-Bonding Acceptors in Organo-Enamine Catalysis. Chemistry. 2015 Aug 10;21(33):11687-91. PubMed PMID: 26178248.
• Liang S, Hammond GB, Xu B. Efficient hydration of alkynes through acid-assisted Brønsted acid catalysis. Chem Commun (Camb). 2015 Jan 18;51(5):903-6. PubMed PMID: 25431814.
• Liang S, Jasinski J, Hammond GB, Xu B. Supported gold nanoparticle-catalyzed hydration of alkynes under basic conditions. Org Lett. 2015 Jan 2;17(1):162-5. PubMed PMID: 25514972.
• Malhotra D, Hammond GB, Xu B. Ligand design in gold catalysis and chemistry of gold-oxonium intermediates. Top Curr Chem. 2015;357:1-23. PubMed PMID: 25707612.
• Xu B, Hammond GB. Rapid chemical reaction workup based on a rigid solvent extraction. Org Lett. 2014 Oct 17;16(20):5238-41. PubMed PMID: 25296390.
• Han J, Lu Z, Hammond GB, Xu B. Synthesis of Pyrrolidines and Pyrroles via Tandem Amination/Cyanation/Alkylation and Amination/Oxidation Sequences. European J Org Chem. 2014 Sep 1;2014(26):5786-5792. PMID: 25386099
• Okoromoba OE, Han J, Hammond GB, Xu B. Designer HF-based fluorination reagent: highly regioselective synthesis of fluoroalkenes and gem-difluoromethylene compounds from alkynes. J Am Chem Soc. 2014 Oct 15;136(41):14381-4. doi: 10.1021/ja508369z. Epub 2014 Oct 2. PMID: 25260170