Associate Professor of Biochemistry & Molecular Genetics

Phone Number: 502-852-7797 (Office)
Fax Number: 502-852-6222
Email david.samuelson@louisville.edu

University of Louisville
Department of Biochemistry & Molecular Genetics
Delia Baxter Building, Room 221
580 South Preston Street
Louisville KY 40292

Additional Appointments:

• Member, James Graham Brown Cancer Center
• Member, Center for Genetics and Molecular Medicine
• Member, Center for Environmental Genomics and Integrative Biology
• Member, Institute for Molecular Diversity and Drug Design

Education:

• Ph. D. 2001 University of Arizona, Tucson
• Post-Doctoral, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison

Laboratory Team Members:

Aaron DenDekker, Graduate Student

Jennifer Sanders, Graduate Student

Bharat Devapatla, Post-Doc

Xiu Xu, Post Doc

Aaron Puckett, Technician

Research Focus:

Breast cancer susceptibility and comparative genetics

Selected Publications:

• Xu X, Ren X, Wang H, Zhao Y, Yi Z, Wang K, Zhang S, Wang L, Samuelson DJ, Hu Z. Identification and functional analysis of acute myeloid leukemia susceptibility associated single nucleotide polymorphisms at non-protein coding regions of RUNX1. Leuk Lymphoma. 2016 Jun;57(6):1442-9. PubMed PMID: 26374622.
• Xu X, Prough RA, Samuelson DJ. Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway. Mol Carcinog. 2015 Feb;54(2):134-47. PubMed PMID: 24008983.
• Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol Carcinog. 2014 Apr;53(4):300-13. PubMed PMID: 23138933.
• Sanders J, Samuelson DJ. Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci. Breast Cancer Res. 2014 Jan 27;16(1):R14. PubMed PMID: 24467842; PubMed Central PMCID: PMC4054882.
• denDekker AD, Xu X, Vaughn MD, Puckett AH, Gardner LL, Lambring CJ, Deschenes L, Samuelson DJ. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q112 and MIER3 is a candidate cancer susceptibility gene. Cancer Res. 2012 Nov 15;72(22):6002-12. PubMed PMID: 22993404; NIHMSID: NIHMS409174; PubMed Central PMCID: PMC3500408.
• Devapatla B, Sanders J, Samuelson DJ. Genetically determined inflammatory-response related cytokine and chemokine transcript profiles between mammary carcinoma resistant and susceptible rat strains. Cytokine. 2012 Aug;59(2):223-7. PubMed PMID: 22609213; NIHMSID: NIHMS374790; PubMed Central PMCID: PMC3377790.
• Smits BM, Sharma D, Samuelson DJ, Woditschka S, Mau B, et al. The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions. Breast Cancer Res. 2011 Aug 16;13(4):R81. PubMed PMID: 21846333; PubMed Central PMCID: PMC3236344.
• Veillet AL, Haag JD, Remfert JL, Meilahn AL, Samuelson DJ, et al. Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. Cancer Prev Res (Phila). 2011 Jan;4(1):97-106. PubMed PMID: 21205740; NIHMSID: NIHMS304756; PubMed Central PMCID: PMC3447625.
• Sanders J, Haag JD, Samuelson DJ. Physical confirmation and mapping of overlapping rat mammary carcinoma susceptibility QTLs, Mcs2 and Mcs6. PLoS One. 2011;6(5):e19891. PubMed PMID: 21625632; PubMed Central PMCID: PMC3097214.
• Samuelson DJ, Hesselson SE, Aperavich BA, Zan Y, Haag JD, et al. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6299-304. PubMed PMID: 17404222; PubMed Central PMCID: PMC1847458.