Research Lab Publications

Maurer Research Publications:  University of Louisville

  1. Ablan, F.D.O., Maurer, M.C. (2023) "Fbg aC 389-420 Enhances Factor XIII Crosslinking via Electrostatic and Hydrophobic Interactions", Biochemistry 62, 2170-81.
  2. Mohammed Syed, R.D., Ablan, F.D.O., McCann, NM, Hindi, M., Maurer, M.C. (2023) "Transglutaminases Activiteis of Blood Coagulant Factor XIII are Dependent on the Activation and Pathways and on the Substrate"  Thrombosis & Haemostasis 123, 380-392. 
  3. Anokhin, B.A., Dean, W.L., Smith, K.A., Flick, M.J., Ariens, RAS, Philippou, H., Maurer, M.C. (2020) “Proteolytic and Nonproteolytic Activation Mechanisms Result in Conformationally and Functionally Different Forms of Coagulation Factor XIII“ FEBS Journal 287, 452-464.
  4. Mouapi, KN., Wagner, L.J., Stephens, C.A., Hindi, M.M., Wilkey, D.W., Merchant, M.L., Maurer, M.C. (2019) “Evaluating the Effects of Fibrinogen αC Mutations on the Ability of Factor XIII to Crosslink the Reactive αC Glutamines (Q237, Q328, Q366)” Thrombosis and Haemostasis 119, 1048-1057.
  5. Billur, R., Sabo, T.M., Maurer, M.C. (2019) “Thrombin Exosite Maturation and Ligand Binding at ABE II Help to Stabilize PAR-Binding Competent Conformation at ABE I” Biochemistry 58, 1048-1060.
  6. Li, B. Billur, R., Maurer, M.C., Kohler, H.P., Raddatz Mueller, P. Alberio, L., Schroeder, V. (2018) “Proline 36 of the Factor XIII Activation Peptide Plays a Crucial Role in Substrate Recognition and Zymogen Activation” Thrombosis and Haemostasis 18, 2037-2045
  7. Hethershaw, E.L., Adamson, P.J., Smith, K.A., Goldsberry. W.N., Pease, R.J., Radford, S.E. Grant, P.J., Ariëns, RAS., Maurer, M.C., Philippou, H. (2018) “The role of beta-barrels 1 and 2 in the enzymatic activity of factor XIII A-subunit” Journal of Thrombosis and Haemostasis 16, 1391-1401.
  8. Billur, R., Ban, D., Sabo, T.M., Maurer, M.C. (2017) “Deciphering Conformational Changes Associated with the Maturation of Thrombin Anion Binding Exosite I” Biochemistry, 56, 6434-6354
  9. Anokhin, B.A., Dean, W.D., Stribinskis, V., Maurer, M.C. (2017) “Activation of Factor XIII is Accompanied by a Change in Oligomerization State" FEBS Journal 284, 3849-3861.
  10. Jadhav, M.A., Goldsberry, W.N., Zink, S.E., Lamb, K.N., Simmons, K.E., Riposo, C.M., Anokhin, B.A., Maurer, M.C. (2017) “Screening Cleavage of Factor XIII V34X Peptides by Thrombin Mutants:  A Strategy for Controlling Fibrin Architecture” BBA:  Proteins and Proteomics 1865, 1246-1254.
  11. Mouapi, K.N., Bell, J.D., Smith, K.A., Ariens, R.A., Philippou H., Maurer, M.C. (2016) “Ranking Reactive Glutamines in the Fibrinogen αC Region That are Targeted by Blood Coagulant Factor XIII” Blood, 127, 2241-8.
  12. Doiphode, P.G., Malovichko, M.V., Mouapi, K.N., Maurer, M.C. (2014) “Evaluating Factor XIII Specificity for Glutamine-Containing Substrates Using a Matrix-Assisted laser Desorption/Ionization Time-of-Flight Mass Spectrometry Assay” Analytical Biochemistry 457, 74-84.
  13. Malovichko, M.V. Sabo, T.M., Maurer, M.C. (2013) “Ligand Binding to Anion-Binding Exosites Regulates Conformational Properties of Thrombin” J. Biol. Chem 288, 8667-78.
  14. Jadhav, M.A., Lucas, R.C., Goldsberry, W.N., Maurer, M.C. (2011) “Design of Factor XIII V34X Activation Peptides to Control Ability to Interact with Thrombin Mutants” BBA Proteins and Proteomics 1814, 1955-1963.
  15. Woofter, R.T., Maurer, M.C. (2011) “Role of Calcium in the Conformational Dynamics of Factor XIII Activation Examined by Hydrogen-Deuterium Exchange Coupled with MALDI-TOF MS” Arch. Biophys. Biochem. 512, 87-95.
  16. Jadhav, M.A., Isetti, G., Trumbo, T.A., Maurer, M.C.  (2010) “Effects of Introducing Fibrinogen Aα Character into the Factor XIII Activation Peptide Segment” Biochemistry 49, 2918-24.
  17. Cleary, D.B, Doiphode, P.G., Maurer, M.C. (2009) “A Non-Reactive Glutamine Residue of α2-Antiplasmin Promotes Interactions with the Factor XIIIa Active Site Region” J. Thromb. Haemost, 7, 1947-1949.
  18. Sabo, T.M., Maurer, M.C. (2009) “Biophysical Investigation of GpIbα Binding to Thrombin Anion Binding Exosite II” Biochemistry 48, 7110-7122.
  19. Sabo, T.M., Brasher, P.B., Maurer, M.C. (2007) “Perturbations in Factor XIII Resulting From Activation and Inhibition Conditions Examined by Solution Based Methods and Detected by MALDI-TOF MS” Biochemistry 46, 10089-10101.
  20. Isetti, G., Maurer, M.C. (2007) “Employing Mutants to Study Thrombin Residues Responsible for Factor XIII Activation Peptide Recognition:  A Kinetic Study” Biochemistry 46, 2444-2452. 
  21. Cleary, D.B., Maurer, M.C. (2006) “Characterizing the Specificity of Activated Factor XIII for Glutamine Containing Substrate Peptides” Biochim. Biophys. Acta 1764, 1207-1217
  22. Sabo, T.M., Farrell, D.H., Maurer, M.C. (2006) “Conformational Analysis of γ′ Peptide (410-427)  Interactions With Thrombin Anion Binding Exosite II” Biochemistry 45, 7434-45.
  23. Maurer, M.C., Trumbo, T.A., Isetti, G., Turner Jr., B.T. (2006) “Probing Interactions Between the  Coagulants Thrombin, Factor XIII, and Fibrin(ogen)” Archives of Biochemistry and Biophysics 445, 36 - 45.
  24. Turner Jr., B.T., Sabo, T.M., Wilding, D., Maurer, M.C. (2004) “Mapping of Factor XIII Solvent  Accessibility as a Function of Activation State Using Chemical Modification Methods” Biochemistry  43, 9755-65.
  25. Isetti, G. Maurer, M.C. (2004) “Thrombin Activity is Unaltered by N-terminal Truncation of Factor XIII Activation Peptides” Biochemistry 43, 4150-4159.
  26. Isetti, G., Maurer, M.C. (2004) “Probing Thrombin's Ability to Accommodate a V34F Substitution Within the Factor XIII Activation Peptide Segment (28-41)”J. Peptide Research 63, 241-252
  27. Trumbo, T.A. Maurer, M.C. (2003) “V34I and V34A Substitutions Within the Factor XIII Activation Peptide Segment (28-41) Affect Interactions with the Thrombin Active Site.” Thrombosis and Haemostasis. 89, 647-53.
  28. Cleary, D.B., Erhinger, W.D., Maurer, M.C. (2003) “Establishing the Inhibitory Effects of Bradykinin on Thrombin” Archives of Biochemistry and. Biophysics. 410, 96-106. 
  29. Marinescu, A., Cleary, D.B, Littlefield, T.R., Maurer, M.C. (2002) “Structural Features Associated With the Binding of Glutamine-Containing Peptides to Factor XIII” Archives of Biochemistry and Biophysics 406, 9-20.
  30. Cleary, D.B., Trumbo, T.A., Maurer, M.C. (2002) “PAR4-like Peptides Bind to Thrombin Through an Optimized Interaction With the Enzyme Active Site Surface” Archives of Biochemistry and Biophysics 403, 179-188.
  31. Turner, B.T., Maurer, M.C. (2002) “Evaluating the Roles of Thrombin and Calcium in Activation of  Coagulation Factor XIII Using H/D Exchange and MALDI-TOF MS” Biochemistry 41, 7947 7954.
  32. Trumbo, T.A., Maurer, M.C. (2002) “Thrombin Hydrolysis of V29F and V34L Mutants of Factor XIII (28-41) Reveals Roles of the P9 and P4 Positions in Factor XIII Activation” Biochemistry 41, 2859-68.
  33. Trumbo, T.A., Maurer, M.C. (2000) “Examining Thrombin Hydrolysis of the Factor XIII Activation Peptide Segment Leads to a Proposal for Explaining the Cardioprotective Effects Observed with the Factor XIII V34L Mutation” J. Biol. Chem. 275, 20627-20631.