January 2023 Member Publications

  1. ElNakieb Y, Ali MT, Elnakib A, Shalaby A, Mahmoud A, Soliman A, Barnes GN, El-Baz A. Understanding the Role of Connectivity Dynamics of Resting-State Functional MRI in the Diagnosis of Autism Spectrum Disorder: A Comprehensive Study. Bioengineering (Basel). 2023 Jan 2;10(1):56. doi: 10.3390/bioengineering10010056. PMID: 36671628; PMCID: PMC9855190.
    Impact Statement: In addition to the standard observational assessment for autism spectrum disorder (ASD), recent advancements in neuroimaging and machine learning (ML) suggest a rapid and objective alternative using brain imaging. As a result of this comprehensive study, we achieve state-of-the-art accuracy, confirming the benefits of the proposed feature representation and feature engineering in extracting useful information as well as the potential benefits of utilizing ML and neuroimaging in the diagnosis and understanding of autism.
  2. Majid S, Weisbrod RM, Fetterman JL, Keith RJ, Rizvi SHM, Zhou Y, Behrooz L, Robertson RM, Bhatnagar A, Conklin DJ, Hamburg NM. Pod-based e-liquids impair human vascular endothelial cell function. PLoS One. 2023 Jan 26;18(1):e0280674. doi: 10.1371/journal.pone.0280674. PMID: 36701344; PMCID: PMC9879485.
    Impact Statement: Results of the present study provide important insights into the association of electronic cigarettes known as pods with endothelial dysfunction – a biomarker of cardiovascular harm. Our results suggest that endothelial impairment induced by e-cigarettes may be, in part, due to impaired eNOS activation to a degree similar to that seen in users of combustible cigarettes. These findings support regulation of tobacco products containing acidified nicotine, as well as the development of product and device standards to limit the generation of harmful or potentially harmful chemicals in e-cigarette aerosols.
  3. Lü L, Yuan F, Fan H, Li Y, Liu J, Feng W, Zhang HG, Chen SY. Ethanol exposure disrupted the formation of radial glial processes and impaired the generation and migration of outer radial glial cells in forebrain organoids derived from human embryonic stem cells. Exp Neurol. 2023 Jan 18;362:114325. doi: 10.1016/j.expneurol.2023.114325. Epub ahead of print. PMID: 36669750.
    Impact Statement: Maternal alcohol abuse during pregnancy can damage the developing fetus and lead to Fetal Alcohol Spectrum Disorders. This study aims to investigate the effects of ethanol exposure on the development of radial glial processes and the generation, migration, and transformation of outer radial glial cells using forebrain organoids generated from human embryonic stem cells. The results from this study provided new insight into the mechanisms underlying ethanol-induced abnormalities in fetal cortical development and FASD in humans.
  4. Naegle MA, Kelly LA, Embree JL, Valentine N, Sharp D, Grinspun D, Hines-Martin VP, Crawford CL, Rosa WE. American academy of nursing consensus recommendations to advance system level change for nurse well-being. Nurs Outlook. 2023 Feb 1;71(2):101917. doi: 10.1016/j.outlook.2023.101917. Epub ahead of print. PMID: 36736029; PMCID: PMC9889942.
    Impact Statement: This paper proposes recommendations from the AAN Expert Panels on Building Health Care System Excellence, Psychiatric Mental Health and Substance Use, and Global Health Expert Panels for the American Academy of Nursing to leverage related policy in the arenas of government and professional/healthcare organizations. Transforming health care work environments and advancing nurse well-being and equity can be accomplished through key, innovative policy changes. These will be achieved through collaboration among associations, organizations, nonprofit groups, and with the public and the media.
  5. Wei H, Price Z, Evans K, Haberstroh A, Hines-Martin V, Harrington CC. The State of the Science of Nurses' Implicit Bias: A Call to Go Beyond the Face of the Other and Revisit the Ethics of Belonging and Power. ANS Adv Nurs Sci. 2023 Jan 10. doi: 10.1097/ANS.0000000000000470. Epub ahead of print. PMID: 36728370.
    Impact Statement: This article summarizes the current state of nurses' implicit bias and discusses the phenomenon from Levinas' face of the Other and ethics of belonging, Watson's human caring and unitary caring science, and Chinn's peace and power theory. Nurses' implicit bias is a global issue; the primary sources of nurses' implicit bias include race/ethnicity, sexuality, health conditions, age, mental health status, and substance use disorders. The current research stays at the descriptive level and addresses implicit bias at the individual level. This article invites nurses to go beyond “the face of the Other” and revisit the ethics of belonging and power.
  6. Tu W, Gawrieh S, Dasarathy S, Mitchell MC, Simonetto DA, Patidar KR, McClain CJ, Bataller R, Szabo G, Tang Q, Barton BA, Radaeva S, Sanyal AJ, Shah V; Alcoholic Hepatitis Network (AlcHepNet) Investigators. Design of a multicenter randomized clinical trial for treatment of Alcohol-Associated Hepatitis. Contemp Clin Trials Commun. 2023 Jan 18;32:101074. doi: 10.1016/j.conctc.2023.101074. PMID: 36698742; PMCID: PMC9869411.
    Impact Statement: Mortality is high for severe alcohol-associated hepatitis (AH). The study provided a direct comparison of the survival benefits and safety profiles of anakinra plus zinc vs. prednisone in patients with severe AH.
  7. Sato T, Head KZ, Li J, Dolin CE, Wilkey D, Skirtich N, Smith K, McCreary DD, Liu S, Beier JI, Singhi AD, McEnaney RM, Merchant ML, Arteel GE. Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2. Matrix Biol Plus. 2022 Dec 28;17:100127. doi: 10.1016/j.mbplus.2022.100127. PMID: 36632559; PMCID: PMC9826883.
    Impact Statement: These results also indicate that analysis of the plasma degradome may yield new insight into the mechanisms of fibrosis recovery, and by extension, new "theragnostic" targets. Lastly, a novel potential role for calpain activation in the degradation and turnover of proteins was identified.
  8. Holm RH, Rempala GA, Choi B, Brick JM, Amraotkar AR, Keith RJ, Rouchka EC, Chariker JH, Palmer KE, Smith T, Bhatnagar A. SARS-CoV-2 wastewater concentration and linked longitudinal seroprevalence: a spatial analysis of strain mutation, post-COVID-19 vaccination effect, and hospitalization burden forecasting. medRxiv [Preprint]. 2023 Jan 7:2023.01.06.23284260. doi: 10.1101/2023.01.06.23284260. PMID: 36656780; PMCID: PMC9844017.
    Impact Statement: Wastewater samples can be used to estimate the effects of vaccination and hospitalization burden. Our study underscores the importance of continued environmental surveillance post-vaccine and provides a proof of concept for environmental epidemiology monitoring.
  9. Wahlang B, Gao H, Rai SN, Keith RJ, McClain CJ, Srivastava S, Cave MC, Bhatnagar A. Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race. Environ Res. 2023 Jan 4;221:115228. doi: 10.1016/j.envres.2023.115228. Epub ahead of print. PMID: 36610539.
    Impact Statement: This study illustrated how our body’s responses to environmental chemicals are different based on biological factors such as sex, lifestyle factors such as smoking, and social constructs such as race. The research findings also highlight the significance of considering biological-social-lifestyle factor(s) interactions when addressing air pollution-related health disparities.
  10. Bolatimi OE, Head KZ, Luo J, Gripshover TC, Lin Q, Adiele NV, Watson WH, Wilkerson C, Cai L, Cave MC, Young JL. Can Zinc Supplementation Attenuate High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease? Int J Mol Sci. 2023 Jan 16;24(2):1763. doi: 10.3390/ijms24021763. PMID: 36675277; PMCID: PMC9864360.
    Impact Statement: Deficiency in the essential micronutrient zinc, the second most concentrated trace mineral in the body, impacts almost 20% of the global population and is implicated in playing a crucial role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), now the most rapidly growing contributor to liver mortality and morbidity. This study investigated the ability of zinc supplementation to attenuate diet-induce NAFLD demonstrated that a sensitive consideration of initiation and duration of administration for therapeutic intervention of zinc must be considered.
  11. Jaggers JR, King KM, McKay T, Dyess RJ, Thrasher BJ, Wintergerst KA. Association between Intensity Levels of Physical Activity and Glucose Variability among Children and Adolescents with Type 1 Diabetes. Int J Environ Res Public Health. 2023 Jan 16;20(2):1623. doi: 10.3390/ijerph20021623. PMID: 36674378; PMCID: PMC9865470.
    Impact Statement: This publication data demonstrated that the total amount of daily physical activity is important when properly managing type 1 diabetes mellitus, but time spent in moderate and vigorous physical activity (MVPA) over two weeks may have an inverse relationship with glucose variability in children and adolescents over a span of two weeks.
  12. Saedi S, Watson SE, Young JL, Tan Y, Wintergerst KA, Cai L. Does maternal low-dose cadmium exposure increase the risk of offspring to develop metabolic syndrome and/or type 2 diabetes? Life Sci. 2023 Feb 15;315:121385. doi: 10.1016/j.lfs.2023.121385. Epub 2023 Jan 9. PMID: 36634865.
    Impact Statement: Cadmium is a hazardous metal with multiple organ toxicity that causes great harm to human health. This review has collected available data to address the current evidence for the potential role of cadmium exposure, leading to insulin resistance and the development of T2D in offspring. Through this comprehensive review, we realize that underlying mechanisms linking prenatal cadmium exposure during pregnancy with T2D in offspring remain to be adequately investigated.