Digestive Surgery Research Laboratory
Dr. Stephen O'Brien and Dr. Katharina Scheurlen, Price Fellows
Professor, Director Digestive Surgery Research Laboratory
Director, Price Institute of Surgical Research
FORGING PATHWAYS OF DISCOVERY
At the Digestive Surgery Research Laboratory, we are fortunate to have researchers from across the United States and abroad who share our enthusiasm and commitment to transform patients' lives through medical research. Their desire for knowledge and understanding drives them in their quest to prevent, better manage, and, one day, cure digestive diseases. As they painstakingly unravel the mysteries of digestive diseases, they are forging new pathways of discovery.
UNDER THE MICROSCOPE
The Price Institute of Surgical Research funds one or two "Price Fellows" each year so that they may obtain a doctorate in philosophy (Ph.D.) while conducting research in the Digestive Surgery Research Laboratory. To learn more about our current research please view our publications. The Digestive Surgery Research Laboratory is located in the Medical Dental Research Building on Floyd Street within the Price Institute for Surgical Research.
Our laboratory focuses on basic molecular research into gastrointestinal diseases including:
- Crohn's Disease
- Ulcerative Colitis
- Colorectal Cancer
WORLD CLASS EXPERTISE IN BASIC RESEARCH
We encourage teamwork—both in the laboratory and in collaboration with researchers at regional, national and international institutions. Together, we apply our expertise to statistical analysis, pathological interpretation, and genetics research.
STATE-OF-THE-ART CLINICAL TRIALS
Our clinical research fellows have access to, and gain experience with, the latest drugs as well as surgical techniques for digestive disorders. This unique focus on medical and surgical treatments allows us to offer some of our patients the opportunity to participate in clinical trials of new medications or to take advantage of new surgical procedures for inflammatory bowel disease and colorectal cancer.
- CRISPR-mediated gene editing for the surgeon scientist. O'Brien SJ, Ekman MB, Manek S, Galandiuk S. Surgery. 2019 Aug;166(2):129-137. doi: 10.1016/j.surg.2019.01.030. Epub 2019 Mar 25. Review.
- Reply to: Atomic bomb and CRISPR gene editing technology. O'Brien SJ, Galandiuk S. Surgery . 2019 Jul 19. pii: S0039-6060(19)30339-3. doi: 10.1016/j.surg.2019.05.052. [Epub ahead of print] No abstract available.
- Plasma microRNA Profile Differentiates Crohn's Colitis From Ulcerative Colitis. Netz U, Carter J, Eichenberger MR, Feagins K, Galbraith NJ, Dryden GW, Pan J, Rai SN, Galandiuk S. Inflamm Bowel Dis. 2017 Dec 19;24(1):159-165. doi: 10.1093/ibd/izx009.
- Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease. Netz U, Carter JV, Eichenberger MR, Dryden GW, Pan J, Rai SN, Galandiuk S. World J Gastroenterol. 2017 Jul 21;23(27):4958-4967. doi: 10.3748/wjg.v23.i27.4958.
- Blood-based microRNAs as biomarkers for the diagnosis of colorectal cancer: a systematic review and meta-analysis. Carter JV, Galbraith NJ, Yang D, Burton JF, Walker SP, Galandiuk S. Br J Cancer. 2017 Mar 14;116(6):762-774. doi: 10.1038/bjc.2017.12. Epub 2017 Feb 2. Review
Genetic polymorphisms in 5-Fluorouracil-related enzymes predict pathologic response after neoadjuvant chemoradiation for rectal cancer. Nelson B, Carter JV, Eichenberger MR, Netz U, Galandiuk S. Surgery. 2016 Nov;160(5):1326-1332. doi: 10.1016/j.surg.2016.05.017. Epub 2016 Jul 14.