Request for Applications: Hepatobiology & Toxicology COBRE

The Hepatobiology & Toxicology COBRE is issuing a Request for Applications (RFA) for new projects. We have one opening, with the possibility of a second opening.

The University of Louisville Hepatobiology and Toxicology COBRE is a unique thematic research center. The University of Louisville (UofL) COBRE scientists comprise a multidisciplinary group of investigators focusing on the mechanisms and therapy for liver injury, nutrition and gut:liver interactions, and liver:environment/toxin/drug interactions. The liver is the largest organ in the body, and is possibly the most complex organ in terms of metabolism. The liver plays a vital role in protein, carbohydrate, and fat metabolism as well as micronutrient metabolism. The liver is the major site for drug and toxin metabolism. It protects the systemic circulation from gut-derived endotoxins, and it protects the body against a variety of environmental and drug-related insults. It also plays a critical role in immune tolerance. Liver diseases are some of the most common and, frequently, poorly recognized health problems afflicting Americans.

We are requesting a 6-page application, following SF424 (R&R) (Specific Aims, Significance, Innovation, Approach) with a section on use of COBRE facilities (e.g., use of core facilities, relevance to overall theme of COBRE, plans for external submission). A mentoring team should be identified and letters of support from the proposed mentors should be included with the application. These letters are not part of the 6-page limit. Potential Project PIs/mentees must be eligible for NIH funding and not have had independent (R01-type) funding previously.

Eligible applicants will be UofL junior faculty investigators (new investigator status) without current or past NIH research R01-level project support. All applications will be scored on a scale of 1-9 using the standard NIH criteria for review of grant proposals (significance, innovation, investigator, approach, environment). Additional criteria will be: likelihood/potential of external funding and significance of the proposed project to the overall theme of the COBRE. In addition, as a condition for receiving COBRE funding, the PI must outline a detailed plan for submitting and receiving extramural funding based on the results of the proposed COBRE project.


Submit applications by 5 pm November 16, 2018 to

Questions: Marion McClain (852-1389)