Publications
Featured Publications
Farley G, Riggs DW, Bhatnagar A, Hellmann J. Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness. Clin Nutr. 2021 Jun;40(6):4097-4105. doi: 10.1016/j.clnu.2021.02.006. Epub 2021 Feb 11. PMID: 33618966; PMCID: PMC8243787.
Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J. Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise. Nutrients. 2020 Aug 11;12(8):2400. doi: 10.3390/nu12082400. PMID: 32796546; PMCID: PMC7468946.
Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PMID: 31653685; PMCID: PMC6864295.
Chuong P, Wysoczynski M, Hellmann J. Do Changes in Innate Immunity Underlie the Cardiovascular Benefits of Exercise? Front Cardiovasc Med. 2019 May 29;6:70. doi: 10.3389/fcvm.2019.00070. PMID: 31192231; PMCID: PMC6549037.
Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M. Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 Sep;138(9):2051-2060. doi: 10.1016/j.jid.2018.03.1498. Epub 2018 Mar 17. PMID: 29559341; PMCID: PMC6109422.
Fredman G, Hellmann J, Proto JD, Kuriakose G, Colas RA, Dorweiler B, Connolly ES, Solomon R, Jones DM, Heyer EJ, Spite M, Tabas I. An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nat Commun. 2016 Sep 23;7:12859. doi: 10.1038/ncomms12859. PMID: 27659679; PMCID: PMC5036151.
Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA, Spite M. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. Circulation. 2016 Aug 30;134(9):666-680. doi: 10.1161/CIRCULATIONAHA.116.021894. Epub 2016 Aug 9. PMID: 27507404; PMCID: PMC5214591.
Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M. CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity. Diabetes. 2016 Aug;65(8):2268-81. doi: 10.2337/db15-1689. Epub 2016 May 3. PMID: 27207557; PMCID: PMC4955992.
Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BD. Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016 Jul;186(7):1801-1813. doi: 10.1016/j.ajpath.2016.03.011. Epub 2016 May 10. PMID: 27171898; PMCID: PMC4929400.
Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015 Aug 21;4(8):e002034. doi: 10.1161/JAHA.115.002034. PMID: 26296857; PMCID: PMC4599461.
Hellmann J, Tang Y, Zhang MJ, Hai T, Bhatnagar A, Srivastava S, Spite M. Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation. Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:49-56. doi: 10.1016/j.prostaglandins.2015.01.001. Epub 2015 Jan 22. PMID: 25619459; PMCID: PMC4386069.
Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14530-5. doi: 10.1073/pnas.1410851111. Epub 2014 Sep 22. PMID: 25246560; PMCID: PMC4210018.
Billeter AT, Hellmann J, Roberts H, Druen D, Gardner SA, Sarojini H, Galandiuk S, Chien S, Bhatnagar A, Spite M, Polk HC Jr. MicroRNA-155 potentiates the inflammatory response in hypothermia by suppressing IL-10 production. FASEB J. 2014 Dec;28(12):5322-36. doi: 10.1096/fj.14-258335. Epub 2014 Sep 17. PMID: 25231976; PMCID: PMC4232280.
Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E262-77. doi: 10.1152/ajpendo.00271.2013. Epub 2014 Jun 10. PMID: 24918202; PMCID: PMC4121575.
Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM. Short-term physical inactivity impairs vascular function. J Surg Res. 2014 Aug;190(2):672-82. doi: 10.1016/j.jss.2014.02.001. Epub 2014 Feb 12. PMID: 24630521; PMCID: PMC4096607.
Billeter AT, Hellmann JL, Bhatnagar A, Polk HC Jr. Transient receptor potential ion channels: powerful regulators of cell function. Ann Surg. 2014 Feb;259(2):229-35. doi: 10.1097/SLA.0b013e3182a6359c. PMID: 23989052.
Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol. 2013 Aug 1;191(3):1383-92. doi: 10.4049/jimmunol.1203369. Epub 2013 Jun 19. PMID: 23785121; PMCID: PMC3720716.
Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M. Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes. 2013 Feb;62(2):618-27. doi: 10.2337/db12-0684. Epub 2012 Oct 5. PMID: 23043160; PMCID: PMC3554373.
Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite M, Bhatnagar A, Hill BG. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res. 2012 Oct 12;111(9):1176-89. doi: 10.1161/CIRCRESAHA.112.266395. Epub 2012 Aug 14. PMID: 22896587; PMCID: PMC3707504.
Hellmann J, Tang Y, Spite M. Proresolving lipid mediators and diabetic wound healing. Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):104-8. doi: 10.1097/MED.0b013e3283514e00. PMID: 22374140; PMCID: PMC4038027.
Spite M, Hellmann J, Tang Y, Mathis SP, Kosuri M, Bhatnagar A, Jala VR, Haribabu B. Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol. 2011 Aug 15;187(4):1942-9. doi: 10.4049/jimmunol.1100196. Epub 2011 Jul 8. PMID: 21742977; PMCID: PMC3150353.
Wheat LA, Haberzettl P, Hellmann J, Baba SP, Bertke M, Lee J, McCracken J, O'Toole TE, Bhatnagar A, Conklin DJ. Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1598-606. doi: 10.1161/ATVBAHA.111.227124. Epub 2011 Apr 28. PMID: 21527748; PMCID: PMC3182098.
Hellmann J, Tang Y, Kosuri M, Bhatnagar A, Spite M. Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J. 2011 Jul;25(7):2399-407. doi: 10.1096/fj.10-178657. Epub 2011 Apr 8. PMID: 21478260; PMCID: PMC3114534.
Baba SP, Hellmann J, Srivastava S, Bhatnagar A. Aldose reductase (AKR1B3) regulates the accumulation of advanced glycosylation end products (AGEs) and the expression of AGE receptor (RAGE). Chem Biol Interact. 2011 May 30;191(1-3):357-63. doi: 10.1016/j.cbi.2011.01.024. Epub 2011 Jan 27. PMID: 21276777; PMCID: PMC3145413.
O'Toole TE, Hellmann J, Wheat L, Haberzettl P, Lee J, Conklin DJ, Bhatnagar A, Pope CA 3rd. Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells. Circ Res. 2010 Jul 23;107(2):200-3. doi: 10.1161/CIRCRESAHA.110.222679. Epub 2010 Jul 1. PMID: 20595651; PMCID: PMC2943671.
O'Toole TE, Zheng YT, Hellmann J, Conklin DJ, Barski O, Bhatnagar A. Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):194-201. doi: 10.1016/j.taap.2009.01.024. Epub 2009 Feb 7. PMID: 19371603; PMCID: PMC2677519.
Murakami H, Bessinger K, Hellmann J, Murakami S. Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans. Neurobiol Aging. 2008 Jul;29(7):1093-100. doi: 10.1016/j.neurobiolaging.2007.01.013. Epub 2007 Mar 1. PMID: 17336425.
Murakami H, Bessinger K, Hellmann J, Murakami S. Aging-dependent and-independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans. J Neurosci. 2005 Nov 23;25(47):10894-904. doi: 10.1523/JNEUROSCI.3600-04.2005. PMID: 16306402; PMCID: PMC6725869.