Jason Hellmann Laboratory
University of Louisville School of Medicine, Center for Cardiometabolic Science,
Division of Environmental Medicine
The Hellmann Lab combines technical expertise in liquid chromatography-tandem mass spectrometry and flow cytometry with models of acute and chronic inflammation to investigate mechanisms that control the magnitude and duration of immune responses.
In doing so, we have contributed to the understanding that chronic inflammation that provokes the development of cardio-metabolic disease (e.g., atherosclerosis and diet-induced insulin resistance/type 2 diabetes) is, in part, due to a failure in pro-resolving signaling pathways.
We have also recently uncovered a novel mechanism by which catecholamines stimulate the production of pro-resolving lipid mediators in macrophages that then contribute to the anti-inflammatory effects of exercise.
Additionally, we aim to understand how to regulate immunometabolism to resolve chronic inflammation.