Featured Publications

For a complete list of Dr. DeFilippis' publications, please visit https://www.ncbi.nlm.nih.gov/myncbi/1fmnSQCWTwtQ2/bibliography/public/.

Updated April 30, 2020

• Owolabi US, Amraotkar AR, Coulter AR, Singam NSV, Aladili BN, Singh A, Trainor PJ, Mitra R, DeFilippis AP. Change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2020 Feb;49(2):235-244. doi: 10.1007/s11239-019-02004-7. PubMed PMID: 31808123.
• DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA. Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury. Circulation. 2019 Nov 12;140(20):1661-1678. doi: 10.1161/CIRCULATIONAHA.119.040631. Epub 2019 Aug 16. PubMed PMID: 31416350.
• Bohula EA, Katz JN, van Diepen S, Alviar CL, Baird-Zars VM, Park JG, Barnett CF, Bhattal G, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis A, Granger CB, Hollenberg S, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel R, Overgaard CB, Phreaner N, Roswell RO, Schulman SP, Snell RJ, Solomon MA, Ternus B, Tymchak W, Vikram F, Morrow DA; Critical Care Cardiology Trials Network. Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness. JAMA Cardiol. 2019 Jul 24. doi: 10.1001/jamacardio.2019.2467. [Epub ahead of print] PubMed PMID: 31339509; PubMed Central PMCID: PMC6659157.
• DeFilippis AP, Nasir K, Blaha MJ. Myocardial Infarction as a Clinical End Point in Research. Circ Res. 2019 Jun 7;124(12):1701-1703. doi: 10.1161/CIRCRESAHA.119.315101. Epub 2019 Jun 6. PubMed PMID: 31170039.
• Keith RJ, Riggs DW, Conklin DJ, Lorkiewicz P, Srivastava S, Bhatnagar A, DeFilippis AP. Nicotine Metabolism in Adults With Type 2 Diabetes. Nicotine Tob Res. 2019 May 21;21(6):846-849. doi: 10.1093/ntr/ntx214. PubMed PMID: 29059414; PubMed Central PMCID: PMC6528156.
  
• DeFilippis AP, Trainor P. When Given a Lemon, Make Lemonade: Revising Cardiovascular Risk Prediction Scores. Ann Intern Med. 2018 Jul 3;169(1):56-57. doi: 10.7326/M18-1175. Epub 2018 Jun 5. PubMed PMID: 29868856.
• Trainor PJ, Yampolskiy RV, DeFilippis AP. Wisdom of artificial crowds feature selection in untargeted metabolomics: An application to the development of a blood-based diagnostic test for thrombotic myocardial infarction. J Biomed Inform. 2018 May;81:53-60. doi: 10.1016/j.jbi.2018.03.007. Epub 2018 Mar 22. PubMed PMID: 29578100; PubMed Central PMCID: PMC5948180.
• Keith RJ, Riggs DW, Conklin DJ, Lorkiewicz P, Srivastava S, Bhatnagar A, DeFilippis AP. Nicotine Metabolism in Adults with Type 2 Diabetes. Nicotine Tob Res. 2017 Sep 27. doi: 10.1093/ntr/ntx214. [Epub ahead of print] PubMed PMID: 29059414.
• Sultan A, Zheng Y, Trainor PJ, Siow Y, Amraotkar AR, Hill BG, DeFilippis AP. Circulating Prolidase Activity in Patients with Myocardial Infarction. Front Cardiovasc Med. 2017 Jul 31;4:50. doi: 10.3389/fcvm.2017.00050. eCollection 2017. PubMed PMID: 28824924; PubMed Central PMCID: PMC5535509.
• Trainor PJ, DeFilippis AP, Rai SN. Evaluation of Classifier Performance for Multiclass Phenotype Discrimination in Untargeted Metabolomics. Metabolites. 2017 Jun 21;7(2). pii: E30. doi: 10.3390/metabo7020030. PubMed PMID: 28635678; PubMed Central PMCID: PMC5488001.
• DeFilippis AP, Trainor PJ, Hill BG, Amraotkar AR, Rai SN, Hirsch GA, Rouchka EC, Bhatnagar A. Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease. PLoS One. 2017 Apr 17;12(4):e0175591. doi: 10.1371/journal.pone.0175591. eCollection 2017. PubMed PMID: 28414761; PubMed Central PMCID: PMC5393610.
• Trainor PJ, Hill BG, Carlisle SM, Rouchka EC, Rai SN, Bhatnagar A, DeFilippis AP. Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction. J Proteomics. 2017 May 8;160:38-46. doi: 10.1016/j.jprot.2017.03.014. Epub 2017 Mar 22. PubMed PMID: 28341595; PubMed Central PMCID: PMC5496773.
• Amraotkar AR, Ghafghazi S, Trainor PJ, Hargis CW, Irfan AB, Rai SN, Bhatnagar A, DeFilippis AP. Presence of multiple coronary angiographic characteristics for the diagnosis of acute coronary thrombus. Cardiol J. 2017;24(1):25-34. doi: 10.5603/CJ.a2017.0004. Epub 2017 Feb 2. PubMed PMID: 28150291; PubMed Central PMCID: PMC5571861.
• Amraotkar AR, Song DD, Otero D, Trainor PJ, Ismail I, Kothari V, Singh A, Moore JB 4th, Rai SN, DeFilippis AP. Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction. Clin Appl Thromb Hemost. 2017 Nov;23(8):1052-1059. doi: 10.1177/1076029616683804. Epub 2016 Dec 21. PubMed PMID: 28294633; PubMed Central PMCID: PMC5572529.
• DeFilippis AP, Young R, McEvoy JW, Michos ED, Sandfort V, Kronmal RA, McClelland RL, Blaha MJ. Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern multi-ethnic cohort. Eur Heart J. 2017 Feb 21;38(8):598-608. doi: 10.1093/eurheartj/ehw301. PubMed PMID: 27436865; PubMed Central PMCID: PMC5837662.
• Keith RJ, Al Rifai M, Carruba C, De Jarnett N, McEvoy JW, Bhatnagar A, Blaha MJ, Defilippis AP. Tobacco Use, Insulin Resistance, and Risk of Type 2 Diabetes: Results from the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2016 Jun 20;11(6):e0157592. doi: 10.1371/journal.pone.0157592. eCollection 2016. PubMed PMID: 27322410; PubMed Central PMCID: PMC4913922.
• Loughran J, Puthawala T, Sutton BS, Brown LE, Pronovost PJ, DeFilippis AP. The Cardiovascular Intensive Care Unit-An Evolving Model for Health Care Delivery. J Intensive Care Med. 2017 Feb;32(2):116-123. doi: 10.1177/0885066615624664. Epub 2016 Jul 8. Review. PubMed PMID: 26768424.
• DeFilippis AP, Blaha MJ. Predicted vs Observed Clinical Event Risk for Cardiovascular Disease. JAMA. 2015 Nov 17;314(19):2082. doi: 10.1001/jama.2015.12916. PubMed PMID: 26575067.
• DeFilippis AP, Chernyavskiy I, Amraotkar AR, Trainor PJ, Kothari S, Ismail I, Hargis CW, Korley FK, Leibundgut G, Tsimikas S, Rai SN, Bhatnagar A. Circulating levels of plasminogen and oxidized phospholipids bound to plasminogen distinguish between atherothrombotic and non-atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2016 Jul;42(1):61-76. doi: 10.1007/s11239-015-1292-5. PubMed PMID: 26510751; PubMed Central PMCID: PMC5403145.
• DeFilippis AP, Young R, Blaha MJ. Calibration and Discrimination Among Multiple Cardiovascular Risk Scores in a Modern Multiethnic Cohort. Ann Intern Med. 2015 Jul 7;163(1):68-9. doi: 10.7326/L15-5105-2. PubMed PMID: 26148287.
• Amraotkar AR, Hargis CW, Cambon AC, Rai SN, Keith MC, Ghafghazi S, Bolli R, DeFilippis AP. Comparison of coliform contamination in non-municipal waters consumed by the Mennonite versus the non-Mennonite rural populations. Environ Health Prev Med. 2015 Sep;20(5):338-46. doi: 10.1007/s12199-015-0472-4. Epub 2015 Jun 12. PubMed PMID: 26068785; PubMed Central PMCID: PMC4550604.
• Amraotkar AR, Pachika A, Grubb KJ, DeFilippis AP. Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. Tex Heart Inst J. 2016 Apr 1;43(2):178-82. doi: 10.14503/THIJ-15-5100. eCollection 2016 Apr. PubMed PMID: 27127440; PubMed Central PMCID: PMC4845572.
• DeFilippis AP, Young R, Carrubba CJ, McEvoy JW, Budoff MJ, Blumenthal RS, Kronmal RA, McClelland RL, Nasir K, Blaha MJ. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med. 2015 Feb 17;162(4):266-75. doi: 10.7326/M14-1281. PubMed PMID: 25686167; PubMed Central PMCID: PMC4414494.
• Carrubba CJ, Blaha MJ, Khurram N, DeFilippis AP.  Cardiovascular Disease Risk Assessment: a Review of Risk Factor-based Algorithms and Assessments of Vascular Health.  Curr Cardiovasc Risk Rep. (2014) 8:419.
• DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, Blumenthal RS, Budoff MJ. Nonalcoholic fatty liver disease and serum lipoproteins: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2013 Apr;227(2):429-36. doi: 10.1016/j.atherosclerosis.2013.01.022. Epub 2013 Jan 29. PubMed PMID: 23419204; PubMed Central PMCID: PMC4049078.
• DeFilippis AP, Blaha MJ, Budoff MJ, Lloyd-Jones DM, McClelland RL, Ndumele C, Lakoski SG, Cushman M, Wong ND,  Blumenthal RS, Lima J, Nasir K.  The Association of Framingham and Reynolds Risk Scores with Incidence and Progression of Coronary Artery Calcification in the Multi-Ethnic Study of Atherosclerosis.  J Am Coll Cardiol. 2011 Nov 8;58(20):2076-83. PMID: 22051329.