Douglas Borchman, Ph. D.
Professor, Department of Ophthalmology and Visual Sciences
Phone Number: (502) 852-7435 (Office)
Fax Number: (502) 852-7450
Room 413, Kentucky Lions Eye Center
Department of Ophthtalmology and Visual Sciences
University of Louisville
301 E. Muhammud Ali Blvd.
Louisville KY 40245
- Professor (secondary appointment), Department of Chemistry
- Professor (secondary appointment), Department of Biochemistry
- Core Faculty, Institute for Advanced Education and Renewable Energy Research Institute
- Ph. D. 1986, Wayne State University
- B.S., Wayne State University
- Post-doctoral, Mount Sinai Hospital
Laboratory Team Members:
- Rimsha Chowha, undergraduate student
- Dylan Gerlach, undergraduate student
- Morgan Hunter, undergraduate student
- Sarah E. Milliner, graduate student
- Alexandria L. Oliver, undergraduate student
- Abigail Schnepf, graduate student
Dr. Borchman received B.S. and Ph.D. degrees from Wayne State Unviersity before completing postdoctoral training at Mount Sinai Hospital in New York. His research is focused on ophthatmology and visual sciences, where his team recently characterized changes in human lens lipid composition with regard to age and cataract. This research led to the discovery of dihydrosphingomyelin, a major lens phospholipid. Dr. Borchman is also leading a group of research associates in studying the structure and interactions of the lipid tear film, which has yet to be fully described on a molecular level.
- Sledge SM, Khimji H, Borchman D, Oliver A, Michael H, et al. Evaporation and Hydrocarbon Chain Conformation of Surface Lipid Films. Ocul Surf. 2016 Jul 6;PubMed PMID: 27395776.
- Mudgil P, Borchman D, Gerlach D, Yappert MC. Sebum/Meibum Surface Film Interactions and Phase Transitional Differences. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2401-11. PubMed PMID: 27145473.
- Ivanova S, Tonchev V, Yokoi N, Yappert MC, Borchman D, et al. Surface Properties of Squalene/Meibum Films and NMR Confirmation of Squalene in Tears. Int J Mol Sci. 2015 Sep 9;16(9):21813-31. PubMed PMID: 26370992; PubMed Central PMCID: PMC4613282.
- Hunter M, Bhola R, Yappert MC, Borchman D, Gerlach D. Pilot study of the influence of eyeliner cosmetics on the molecular structure of human meibum. Ophthalmic Res. 2015;53(3):131-5. PubMed PMID: 25720840.
- Borchman D, Yappert MC, Milliner SE, Smith RJ, Bhola R. Confirmation of the presence of squalene in human eyelid lipid by heteronuclear single quantum correlation spectroscopy. Lipids. 2013 Dec;48(12):1269-77. PubMed PMID: 24081494.
- Mudgil P, Borchman D, Yappert MC, Duran D, Cox GW, et al. Lipid order, saturation and surface property relationships: a study of human meibum saturation. Exp Eye Res. 2013 Nov;116:79-85. PubMed PMID: 23973715.
- Borchman D, Yappert MC, Milliner SE, Duran D, Cox GW, et al. 13C and 1H NMR ester region resonance assignments and the composition of human infant and child meibum. Exp Eye Res. 2013 Jul;112:151-9. PubMed PMID: 23644094.
- Foulks GN, Borchman D, Yappert M, Kakar S. Topical azithromycin and oral doxycycline therapy of meibomian gland dysfunction: a comparative clinical and spectroscopic pilot study. Cornea. 2013 Jan;32(1):44-53. PubMed PMID: 22668581; NIHMSID: NIHMS369067; PubMed Central PMCID: PMC4138220.
- Vishnubhatla S, Borchman D, Foulks GN. Contact lenses and the rate of evaporation measured in vitro; the influence of wear, squalene and wax. Cont Lens Anterior Eye. 2012 Dec;35(6):277-81. PubMed PMID: 22906863.
- Faheem S, Kim SH, Nguyen J, Neravetla S, Ball M, Foulks GN, Yappert MC, Borchman D. Wax-tear and meibum protein, wax-β-carotene interactions in vitro using infrared spectroscopy. Exp Eye Res. 2012 Jul;100:32-9. PubMed PMID: 22564968; NIHMSID: NIHMS373869; PubMed Central PMCID: PMC3575094.